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Quantification of lung tumor rotation with automated landmark extraction using orthogonal cine MRI images.

Abstract：

:The quantification of tumor motion in sites affected by respiratory motion is of primary importance to improve treatment accuracy. To account for motion, different studies analyzed the translational component only, without focusing on the rotational component, which was quantified in a few studies on the prostate with implanted markers. The aim of our study was to propose a tool able to quantify lung tumor rotation without the use of internal markers, thus providing accurate motion detection close to critical structures such as the heart or liver. Specifically, we propose the use of an automatic feature extraction method in combination with the acquisition of fast orthogonal cine MRI images of nine lung patients. As a preliminary test, we evaluated the performance of the feature extraction method by applying it on regions of interest around (i) the diaphragm and (ii) the tumor and comparing the estimated motion with that obtained by (i) the extraction of the diaphragm profile and (ii) the segmentation of the tumor, respectively. The results confirmed the capability of the proposed method in quantifying tumor motion. Then, a point-based rigid registration was applied to the extracted tumor features between all frames to account for rotation. The median lung rotation values were  -0.6   ±   2.3° and  -1.5   ±   2.7° in the sagittal and coronal planes respectively, confirming the need to account for tumor rotation along with translation to improve radiotherapy treatment.

journal_name

Phys Med Biol

journal_title

Physics in medicine and biology

authors

Paganelli C,Lee D,Greer PB,Baroni G,Riboldi M,Keall P

doi

10.1088/0031-9155/60/18/7165

subject

Has Abstract

pub_date

2015-09-21 00:00:00

pages

7165-78

issue

18

eissn

0031-9155

issn

1361-6560

journal_volume

60

pub_type

杂志文章

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