Intraoperative evaluation of device placement in spine surgery using known-component 3D-2D image registration.

Abstract:

:Intraoperative x-ray radiography/fluoroscopy is commonly used to assess the placement of surgical devices in the operating room (e.g. spine pedicle screws), but qualitative interpretation can fail to reliably detect suboptimal delivery and/or breach of adjacent critical structures. We present a 3D-2D image registration method wherein intraoperative radiographs are leveraged in combination with prior knowledge of the patient and surgical components for quantitative assessment of device placement and more rigorous quality assurance (QA) of the surgical product. The algorithm is based on known-component registration (KC-Reg) in which patient-specific preoperative CT and parametric component models are used. The registration performs optimization of gradient similarity, removes the need for offline geometric calibration of the C-arm, and simultaneously solves for multiple component bodies, thereby allowing QA in a single step (e.g. spinal construct with 4-20 screws). Performance was tested in a spine phantom, and first clinical results are reported for QA of transpedicle screws delivered in a patient undergoing thoracolumbar spine surgery. Simultaneous registration of ten pedicle screws (five contralateral pairs) demonstrated mean target registration error (TRE) of 1.1  ±  0.1 mm at the screw tip and 0.7  ±  0.4° in angulation when a prior geometric calibration was used. The calibration-free formulation, with the aid of component collision constraints, achieved TRE of 1.4  ±  0.6 mm. In all cases, a statistically significant improvement (p  <  0.05) was observed for the simultaneous solutions in comparison to previously reported sequential solution of individual components. Initial application in clinical data in spine surgery demonstrated TRE of 2.7  ±  2.6 mm and 1.5  ±  0.8°. The KC-Reg algorithm offers an independent check and quantitative QA of the surgical product using radiographic/fluoroscopic views acquired within standard OR workflow. Such intraoperative assessment could improve quality and safety, provide the opportunity to revise suboptimal constructs in the OR, and reduce the frequency of revision surgery.

journal_name

Phys Med Biol

authors

Uneri A,De Silva T,Goerres J,Jacobson MW,Ketcha MD,Reaungamornrat S,Kleinszig G,Vogt S,Khanna AJ,Osgood GM,Wolinsky JP,Siewerdsen JH

doi

10.1088/1361-6560/aa62c5

subject

Has Abstract

pub_date

2017-04-21 00:00:00

pages

3330-3351

issue

8

eissn

0031-9155

issn

1361-6560

journal_volume

62

pub_type

杂志文章
  • SimDoseCT: dose reporting software based on Monte Carlo simulation for a 320 detector-row cone-beam CT scanner and ICRP computational adult phantoms.

    abstract::This study aims to develop and test software for assessing and reporting doses for standard patients undergoing computed tomography (CT) examinations in a 320 detector-row cone-beam scanner. The software, called SimDoseCT, is based on the Monte Carlo (MC) simulation code, which was developed to calculate organ doses a...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa77ea

    authors: Cros M,Joemai RMS,Geleijns J,Molina D,Salvadó M

    更新日期:2017-07-17 00:00:00

  • Theoretical modeling of yields for proton-induced reactions on natural and enriched molybdenum targets.

    abstract::Recent acute shortage of medical radioisotopes prompted investigations into alternative methods of production and the use of a cyclotron and ¹⁰⁰Mo(p,2n)(99m)Tc reaction has been considered. In this context, the production yields of (99m)Tc and various other radioactive and stable isotopes which will be created in the ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/17/002

    authors: Celler A,Hou X,Bénard F,Ruth T

    更新日期:2011-09-07 00:00:00

  • Electric fields induced in humans and rodents by 60 Hz magnetic fields.

    abstract::Numerical computations are used to evaluate electric field dosimetry for high-resolution anatomically based inhomogeneous models of a human male child, and male and female rats and mice, under exposure to 60 Hz uniform magnetic field sources of three perpendicular orientations. The goal is to compare the child data to...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/14/313

    authors: Dawson TW,Caputa K,Stuchly MA

    更新日期:2002-07-21 00:00:00

  • Factors affecting in vivo measurement precision and accuracy of 109Cd K x-ray fluorescence measurements.

    abstract::109Cd K x-ray fluorescence (XRF) measurement systems from two research centres were used to measure tibia lead content in a population (n = 530) of young adults. The group mean bone lead contents (+/-SEM) determined by McMaster University (n = 214) and the University of Maryland (n = 316) were 2.80 +/- 0.51 and 2.33 +...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/9/313

    authors: McNeill FE,Stokes L,Chettle DR,Kaye WE

    更新日期:1999-09-01 00:00:00

  • Semi-empirical formulation of multiple scattering for the Gaussian beam model of heavy charged particles stopping in tissue-like matter.

    abstract::Dose calculation for radiotherapy with protons and heavier ions deals with a large volume of path integrals involving a scattering power of body tissue. This work provides a simple model for such demanding applications. There is an approximate linearity between RMS end-point displacement and range of incident particle...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/5/N01

    authors: Kanematsu N

    更新日期:2009-03-07 00:00:00

  • Sensitivity study of the microdosimetric kinetic model parameters for carbon ion radiotherapy.

    abstract::In carbon ion therapy treatment planning, the relative biological effectiveness (RBE) is accounted for by optimization of the RBE-weighted dose (biological dose). The RBE calculation methods currently applied clinically in carbon ion therapy are derived from the microdosimetric kinetic model (MKM) in Japan and the loc...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aae8b4

    authors: Dahle TJ,Magro G,Ytre-Hauge KS,Stokkevåg CH,Choi K,Mairani A

    更新日期:2018-11-12 00:00:00

  • Symmetries of the 2D magnetic particle imaging system matrix.

    abstract::In magnetic particle imaging (MPI), the relation between the particle distribution and the measurement signal can be described by a linear system of equations. For 1D imaging, it can be shown that the system matrix can be expressed as a product of a convolution matrix and a Chebyshev transformation matrix. For multidi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/10/4033

    authors: Weber A,Knopp T

    更新日期:2015-05-21 00:00:00

  • Accurate helical cone-beam CT reconstruction with redundant data.

    abstract::We present a new image reconstruction algorithm for helical cone-beam computed tomography (CT). This algorithm is designed for data collected at or near maximum pitch, and provides a theoretically exact and stable reconstruction while beneficially using all measured data. The main operations involved are a differentia...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/15/001

    authors: Schöndube H,Stierstorfer K,Noo F

    更新日期:2009-08-07 00:00:00

  • Radiation damage, repopulation and cell recovery analysis of in vitro tumour cell megacolony culture data using a non-Poissonian cell repopulation TCP model.

    abstract::The effects of radiation damage, tumour repopulation and cell sublethal damage repair and the possibility of extracting information about the model parameters describing them are investigated in this work. Previously published data on two different cultured cell lines were analysed with the help of a tumour control pr...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/13/006

    authors: Stavrev P,Weldon M,Warkentin B,Stavreva N,Fallone BG

    更新日期:2005-07-07 00:00:00

  • GGEMS-Brachy: GPU GEant4-based Monte Carlo simulation for brachytherapy applications.

    abstract::In brachytherapy, plans are routinely calculated using the AAPM TG43 formalism which considers the patient as a simple water object. An accurate modeling of the physical processes considering patient heterogeneity using Monte Carlo simulation (MCS) methods is currently too time-consuming and computationally demanding ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/13/4987

    authors: Lemaréchal Y,Bert J,Falconnet C,Després P,Valeri A,Schick U,Pradier O,Garcia MP,Boussion N,Visvikis D

    更新日期:2015-07-07 00:00:00

  • Correlation between human and model observer performance for discrimination task in CT.

    abstract::Although physical metrics can objectively characterize computed tomography (CT) image quality, quantitative approaches to predict human observer performance are more accurate and clinically relevant. This study compared a modified channelized Hotelling model observer (CHO) with human observers in a shape discriminatio...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/13/3389

    authors: Zhang Y,Leng S,Yu L,Carter RE,McCollough CH

    更新日期:2014-07-07 00:00:00

  • Towards clinical application: prompt gamma imaging of passively scattered proton fields with a knife-edge slit camera.

    abstract::Prompt γ-ray imaging with a knife-edge shaped slit camera provides the possibility of verifying proton beam range in tumor therapy. Dedicated experiments regarding the characterization of the camera system have been performed previously. Now, we aim at implementing the prototype into clinical application of monitoring...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/22/7881

    authors: Priegnitz M,Barczyk S,Nenoff L,Golnik C,Keitz I,Werner T,Mein S,Smeets J,Vander Stappen F,Janssens G,Hotoiu L,Fiedler F,Prieels D,Enghardt W,Pausch G,Richter C

    更新日期:2016-11-21 00:00:00

  • A feasibility study of the use of fluorescence bronchoscopy for localization of small lung tumours.

    abstract::The possible use of fluorescence bronchoscopy for localization of bronchogenic tumours at the carcinoma in situ stage has been investigated. The target lesion is 80 micrometer thick with a mass of 250 microgram, containing 250 pg of haematoporphyrin derivative. The injected haematoporphyrin-derivative is preferentiall...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/22/5/014

    authors: Profio AE,Doiron DR

    更新日期:1977-09-01 00:00:00

  • Penetration of electromagnetic fields of an open-ended coaxial probe between 1 MHz and 1 GHz in dielectric skin measurements.

    abstract::An open-ended coaxial probe is often used for investigating the dielectric properties of biological tissues. The present study indicates that in addition to the probe size, the penetration of the electromagnetic (EM) fields of an open-ended coaxial probe in contact with the skin is dependent on the applied frequency b...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/7/404

    authors: Alanen E,Lahtinen T,Nuutinen J

    更新日期:1999-07-01 00:00:00

  • Monitoring of airborne contamination during the handling of technetium-99m and radioiodine.

    abstract::Measurements have been made using an air sampler to measure airborne radioactivity produced during the routine handling of large activities of technetium-99m, iodine-125 and iodine-131. The results indicate that 99Tcm can be safely handled in environments without direct exhaust of the ventilated air but that 125I and ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/25/6/005

    authors: Eadie AS,Horton PW,Hilditch TE

    更新日期:1980-11-01 00:00:00

  • Production of clinically useful positron emitter beams during carbon ion deceleration.

    abstract::In external beam radiation therapy, radioactive beams offer the best clinical solution to simultaneously treat and in vivo monitor the dose delivery and tumor response using PET or PET-CT imaging. However, difficulties mainly linked to the low production efficiency have so far limited their use. This study is devoted ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/6/005

    authors: Lazzeroni M,Brahme A

    更新日期:2011-03-21 00:00:00

  • Bulk optical properties of healthy female breast tissue.

    abstract::We have measured the bulk optical properties of healthy female breast tissues in vivo in the parallel plate, transmission geometry. Fifty-two volunteers were measured. Blood volume and blood oxygen saturation were derived from the optical property data using a novel method that employed a priori spectral information t...

    journal_title:Physics in medicine and biology

    pub_type: 临床试验,杂志文章

    doi:10.1088/0031-9155/47/16/302

    authors: Durduran T,Choe R,Culver JP,Zubkov L,Holboke MJ,Giammarco J,Chance B,Yodh AG

    更新日期:2002-08-21 00:00:00

  • Optimizing 4DCBCT projection allocation to respiratory bins.

    abstract::4D cone beam computed tomography (4DCBCT) is an emerging image guidance strategy used in radiotherapy where projections acquired during a scan are sorted into respiratory bins based on the respiratory phase or displacement. 4DCBCT reduces the motion blur caused by respiratory motion but increases streaking artefacts d...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/19/5631

    authors: O'Brien RT,Kipritidis J,Shieh CC,Keall PJ

    更新日期:2014-10-07 00:00:00

  • A limited-angle CT reconstruction method based on anisotropic TV minimization.

    abstract::This paper presents a compressed sensing (CS)-inspired reconstruction method for limited-angle computed tomography (CT). Currently, CS-inspired CT reconstructions are often performed by minimizing the total variation (TV) of a CT image subject to data consistency. A key to obtaining high image quality is to optimize t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/7/2119

    authors: Chen Z,Jin X,Li L,Wang G

    更新日期:2013-04-07 00:00:00

  • FDTD analysis of human body-core temperature elevation due to RF far-field energy prescribed in the ICNIRP guidelines.

    abstract::This study investigated the relationship between the specific absorption rate and temperature elevation in an anatomically-based model named NORMAN for exposure to radio-frequency far fields in the ICNIRP guidelines (1998 Health Phys. 74 494-522). The finite-difference time-domain method is used for analyzing the elec...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/16/020

    authors: Hirata A,Asano T,Fujiwara O

    更新日期:2007-08-21 00:00:00

  • An image processing technique for the identification of contact pixels applied to x-ray CT images of implanted hip prostheses.

    abstract::Uncemented prosthetic joint implants used in orthopaedic surgery are usually coated with a porous surface to encourage bone ingrowth. Better contact between the endosteal bone and the porous surface improves ingrowth, and such contact may be increased if the joint further subsides into position in the first weeks foll...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/38/2/009

    authors: Berry E,Langkamer VG,Jackson PC,Snow M,Goddard PR,Wells PN

    更新日期:1993-02-01 00:00:00

  • An absorptiometry method for the determination of arterial blood concentration of injected iodinated contrast agent.

    abstract::A single photon absorptiometry method to measure the arterial concentration of injected iodinated contrast agent was developed. A prototype absorptiometry unit was built which consists of either a square or circular cross section acrylic (polymethylmethacrylate) cuvette connected to an arterial catheter at one end and...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/37/9/002

    authors: Yeung WT,Lee TY,Del Maestro RF,Kozak R,Bennett JD,Brown T

    更新日期:1992-09-01 00:00:00

  • Effect of inter-crystal scatter on estimation methods for random coincidences and subsequent correction.

    abstract::Random coincidences can contribute substantially to the background in positron emission tomography (PET). Several estimation methods are being used for correcting them. The goal of this study was to investigate the validity of techniques for random coincidence estimation, with various low-energy thresholds (LETs). Sim...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/9/012

    authors: Torres-Espallardo I,Rafecas M,Spanoudaki V,McElroy DP,Ziegler SI

    更新日期:2008-05-07 00:00:00

  • Development of a fast Monte Carlo dose calculation system for online adaptive radiation therapy quality assurance.

    abstract::Online adaptive radiation therapy (ART) based on real-time magnetic resonance imaging represents a paradigm-changing treatment scheme. However, conventional quality assurance (QA) methods based on phantom measurements are not feasible with the patient on the treatment couch. The purpose of this work is to develop a fa...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa6e38

    authors: Wang Y,Mazur TR,Park JC,Yang D,Mutic S,Li HH

    更新日期:2017-06-21 00:00:00

  • A potential method for in vivo range verification in proton therapy treatment.

    abstract::Proton therapy potentially offers excellent dose conformality and reduction in integral dose. The superior dose distribution is, however, much more sensitive to the radiological depth along the beam path than for photon fields. Variations in this depth due to inaccurate planning calculation, setup uncertainty, respira...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/5/016

    authors: Lu HM

    更新日期:2008-03-07 00:00:00

  • Simulation of small-angle x-ray scattering from collagen fibrils and comparison with experimental patterns.

    abstract::Simulation of small-angle x-ray scattering from collagen in healthy and cancerous breast tissue may reveal detailed information on the structural changes in collagen. Collagen fibril is modelled as a cylinder with axially periodic step-function electron density, and packing is approximated by placing the cylinders in ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/22/012

    authors: Suhonen H,Fernández M,Serimaa R,Suortti P

    更新日期:2005-11-21 00:00:00

  • Robust fluence map optimization via alternating direction method of multipliers with empirical parameter optimization.

    abstract::For the treatment planning during intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT), beam fluence maps can be first optimized via fluence map optimization (FMO) under the given dose prescriptions and constraints to conformally deliver the radiation dose to the targets while sparin...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/7/2838

    authors: Gao H

    更新日期:2016-04-07 00:00:00

  • Comparative efficiency of the multi-leaf collimator and variable-aperture collimator in intensity-modulated radiotherapy.

    abstract::The potential of the variable-aperture collimator (VAC) in intensity-modulated radiation therapy (IMRT) has been evaluated by comparing its performance with that of the multi-leaf collimator (MLC). This comparison used a decomposition algorithm to find the series of collimator segments that would treat a given intensi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/7/006

    authors: Anderson JW,Symonds-Tayler R,Hartmann G,Echner G,Lang C,Schlegel W,Webb S

    更新日期:2006-04-07 00:00:00

  • Filter materials for dose reduction in screen-film radiography.

    abstract::A computer program was developed to calculate both integral absorbed dose in a water phantom and entrance exposure, for the imaging of iodine contrast with x-ray intensifying screens. The effect of filtration of the x-ray beam on integral absorbed dose and entrance exposure was studied for 27 different filter material...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/31/6/001

    authors: Koedooder K,Venema HW

    更新日期:1986-06-01 00:00:00

  • Comparison of two-compartment exchange and continuum models of dMRI in skeletal muscle.

    abstract::Clinical diffusion MRI (dMRI) is sensitive to micrometer scale spin displacements, but the image resolution is  ∼mm, so the biophysical interpretation of the signal relies on establishing appropriate subvoxel tissue models. A class of two-compartment exchange models originally proposed by Kärger have been used success...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab2aa6

    authors: Naughton NM,Georgiadis JG

    更新日期:2019-08-01 00:00:00