Abstract：
:Influenza vaccines minimize the risk of influenza-related morbidity, complication, and death in elderly people. Although evaluating vaccine effectiveness (VE) is important for promoting immunization programs and coping with influenza epidemics, it is difficult to evaluate its effectiveness in Japan, where no frameworks to use large databases, such as a vaccination registry and health maintenance organization datasets, are available. Therefore, another analytic epidemiological investigations to evaluate VE in Japan are required. Herein, we describe the basic principles of a cohort study, which might be the most comprehensive, but expensive, study design. It is particularly important to be aware of the potential bias and confounding factors that should be minimized in the study design and analysis. We focus on "laboratory-confirmed influenza" and "influenza-like illness", and discuss why it is important to follow up with equal intensity, and how to control for bias; problems that often arise in population-based observational cohort studies.
journal_name
Vaccinejournal_title
Vaccineauthors
Hara M,Hirota Ydoi
10.1016/j.vaccine.2017.07.002subject
Has Abstractpub_date
2017-08-24 00:00:00pages
4791-4795issue
36eissn
0264-410Xissn
1873-2518pii
S0264-410X(17)30898-8journal_volume
35pub_type
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