Abstract:
:It is usually assumed that co-expressed genes suggest co-regulation in the underlying regulatory network. Determining sets of co-expressed genes is an important task, based on some criteria of similarity. This task is usually performed by clustering algorithms, where the genes are clustered into meaningful groups based on their expression values in a set of experiment. In this work, we propose a method to find sets of co-expressed genes, based on cluster validation indices as a measure of similarity for individual gene groups, and a combination of variants of hierarchical clustering to generate the candidate groups. We evaluated its ability to retrieve significant sets on simulated correlated and real genomics data, where the performance is measured based on its detection ability of co-regulated sets against a full search. Additionally, we analyzed the quality of the best ranked groups using an online bioinformatics tool that provides network information for the selected genes.
journal_name
Genomicsjournal_title
Genomicsauthors
Pagnuco IA,Pastore JI,Abras G,Brun M,Ballarin VLdoi
10.1016/j.ygeno.2017.06.009subject
Has Abstractpub_date
2017-10-01 00:00:00pages
438-445issue
5-6eissn
0888-7543issn
1089-8646pii
S0888-7543(17)30057-5journal_volume
109pub_type
杂志文章相关文献
GENOMICS文献大全abstract::Receiver operating characteristic (ROC) has been widely used to evaluate statistical methods, but a fatal problem is that ROC cannot evaluate estimation of the false discovery rate (FDR) of a statistical method and hence the area under of curve as a criterion cannot tell us if a statistical method is conservative. To ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2011.05.006
更新日期:2011-11-01 00:00:00
abstract::A somatic cell hybrid panel, consisting of 25 cell lines, has been developed to localize loci subregionally on chromosome 22. Over 300 markers in the form of STSs or hybridization probes have been assigned to one of 24 unique regions or "bins" using this panel. This ordered collection of markers will aid in the assemb...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0358
更新日期:1996-07-15 00:00:00
abstract::In this study, through linkage analysis of a four-generation Chinese family with multiple members afflicted with DGI (type II), we identified a novel missense mutation in DSPP. The mutation was located in exon 2 at the second nucleotide position of the last codon and resulted in a substitution of a proline with a leuc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2012.01.006
更新日期:2012-04-01 00:00:00
abstract::We mapped a new X-linked recessive atrophic macular degeneration locus to Xp21.1-p11.4 and show allelic involvement of the gene RPGR, which normally causes severe peripheral retinal degeneration leading to global blindness. Ten affected males whom we examined had primarily macular atrophy causing progressive loss of v...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.6815
更新日期:2002-08-01 00:00:00
abstract::The search for the gene for choroideremia (MIM 30310), a rare retinal dystrophy, has been of great interest due to the existence of several choroideremia patients with well-defined structural chromosome aberrations, thus providing the basis for a reverse genetics approach to the isolation of this disease gene. This re...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90494-f
更新日期:1990-04-01 00:00:00
abstract::The GM2 activator locus (GM2A) had previously been considered as a candidate gene for some forms of spinal muscular atrophy (SMA; mapped to 5q11.2-q13.3). It was eliminated as a possible candidate because PCR-based mapping failed to localize the gene to chromosome 5, as was previously reported using an ELISA-based met...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1491
更新日期:1993-11-01 00:00:00
abstract::Background Bioinformatics tools are of great significance and are used in different spheres of life sciences. There are wide variety of tools available to perform primary analysis of DNA and protein but most of them are available on different platforms and many remain undetected. Accessing these tools separately to pe...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.08.010
更新日期:2020-11-01 00:00:00
abstract::Human Xq27 contains candidate regions for several disorders, yet is predicted to be a gene-poor cytogenetic band. We have developed a transcription map for the entire cytogenetic band to facilitate the identification of the relatively small number of expected candidate genes. Two approaches were taken to identify gene...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.5768
更新日期:1999-04-15 00:00:00
abstract::Biologic effects of androgen on target cells are mediated in part by transcriptional regulation of androgen-regulated genes (ARGs) by androgen receptor. Using serial analysis of gene expression (SAGE), we have identified a comprehensive repertoire of ARGs in LNCaP cells. One of the SAGE-derived tags exhibiting homolog...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6214
更新日期:2000-06-15 00:00:00
abstract::The human MAGE1 gene directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. MAGE1 belongs to a family of genes that are expressed in a number of tumors of various histological types but not in normal tissues except testis. The MAGE genes are arranged in two groups that are...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1108
更新日期:1995-07-01 00:00:00
abstract::The sequence of the gorilla alpha-fetoprotein gene, including 869 base pairs of the 5' flanking region and 4892 base pairs of the 3' flanking region (24,607 in total), was determined from two overlapping lambda phage clones. The sequence extends 18,846 base pairs from the Cap site to the polyadenylation site, and it r...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90221-y
更新日期:1991-01-01 00:00:00
abstract::Proprotein convertase 4 (PC4) is a mammalian secretory serine endoproteinase similar to the yeast KEX2 gene product and specifically expressed in testicular germs cells. PC4 mRNA isoforms that vary in size and 3' coding sequence have been reported (N. G. Seitah, R. Day, J. Hamelin, A. Gaspar, M. W. Collard, and M. Chr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1158
更新日期:1994-03-15 00:00:00
abstract::We describe a high-resolution radiation hybrid map of human chromosome 11q22-q23 containing the ataxia-telangiectasia (AT) disease gene loci. The order and intermarker distances of 32 chromosome 11q22-q23 markers were determined by a multipoint maximum likelihood method of analysis of the cosegregation of markers in 1...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1275
更新日期:1993-07-01 00:00:00
abstract::Regions of the genome showing high evolutionary stability are often conserved as a result of functional constraints. Conversely, more variable regions are likely to represent DNA with no functional or structural importance. However, as in the case of immunologically important regions, sequence divergence does not alwa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90170-j
更新日期:1991-10-01 00:00:00
abstract::This work describes a novel method, multiplex solid-phase fluorescent minisequencing, for the simultaneous detection of several point mutations and/or small deletions and insertions. The method is applied to the analysis of mitochondrial DNA polymorphisms for the purposes of individual identification. A database of 15...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0247
更新日期:1996-05-15 00:00:00
abstract::A full-length cDNA coding for mouse plasminogen has been isolated and characterized. The cDNA is 2720 bp in length (excluding the poly(A) tail) and contains a 24-bp 5' noncoding region, an open reading frame of 2436 bp, and a 3' noncoding region of 257 bp. The open reading frame codes for 812 amino acids and includes ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90225-j
更新日期:1990-09-01 00:00:00
abstract::We mapped the owl monkey colony-stimulating factor 1 receptor (CSF1R) locus to the proximal region of chromosome 3q of karyotype VI(K-VI) and karyotype V(K-V) and the interleukin 5 (IL5) locus to the mid-region of chromosome 3q(K-VI) and 19q(K-IV) using a combination of Southern hybridization of somatic cells and in s...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90034-p
更新日期:1992-08-01 00:00:00
abstract::Creating transgenic mice is an important technology for genetic studies and is currently performed by pronuclear microinjection of plasmid DNA into fertilized eggs. Since survival of injected embryos and integration of plasmid DNA are not efficient, total efficiency is only around 3% with a standard protocol. To circu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2010.02.006
更新日期:2010-05-01 00:00:00
abstract::Nitric oxide (NO) is an important molecular messenger regulating the functions of a wide variety of cells and tissues. NO is synthesized from L-arginine by a variety of isoforms of the enzyme nitric oxide synthase (NOS). We have used Southern blotting analysis on DNAs obtained from a panel of human-rodent hybrid cell ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1286
更新日期:1994-05-15 00:00:00
abstract::We have constructed a 1-Mb contig in human chromosomal band 11p15.5, a region implicated in the etiology of several embryonal tumors, including Wilms tumor, and in Beckwith-Wiedemann syndrome. Cosmid, P1, PAC, and BAC clones were characterized by NotI/SalI digestion and hybridized to a variety of probes to generate a ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4826
更新日期:1997-08-01 00:00:00
abstract::In this report the identification, structure, and chromosomal localization of the human neurogranin gene (NRGN) are described. NRGN is the human homolog of the rat Ng/RC3 gene, which encodes a brain-specific protein expressed in telencephalic neurons. The human NRGN gene spans approximately 12 kb and contains four exo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4622
更新日期:1997-04-15 00:00:00
abstract::To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885, rs2839698, rs3741206, rs3741219) were found to be related with EOC risk. Specifi...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.02.002
更新日期:2020-05-01 00:00:00
abstract::A large insert canine genomic bacterial artificial chromosome (BAC) library was built from a Doberman pinscher. Approximately 166,000 clones were gridded on nine high-density hybridization filters. Insert analysis of randomly selected clones indicated a mean insert size of 155 kb and predicted 8.1 coverage of the cani...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.5772
更新日期:1999-05-15 00:00:00
abstract::The myotonic dystrophy (DM) region has been recently shown to be bracketed by two key recombinant events. One recombinant occurs in a Dutch DM family, which maps the DM locus distal to the ERCC1 gene and D19S115 (pE0.8). The other recombinant event is in a French Canadian DM family, which maps DM proximal to D19S51 (p...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90119-d
更新日期:1992-07-01 00:00:00
abstract::The role of hyaluronan in cardiac growth has become evident, previously shown by increased myocardial levels of hyaluronan in a rat model of cardiac hypertrophy. To further investigate the role of hyaluronan and regulation of its synthesis in cardiac hypertrophy, quantitative measurements of myocardial hyaluronan conc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2010.04.003
更新日期:2010-08-01 00:00:00
abstract::Histamine N-methyltransferase (HNMT), a cytosolic histamine-metabolizing enzyme, is the only known product of the 50-kb human HNMT. Here, a detailed investigation of HNMT products revealed the existence of a new brain mRNA product of HNMT. This species, named HNMT-Short (HNMT-S), encodes a 126-amino-acid protein. Nort...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00236-2
更新日期:2004-01-01 00:00:00
abstract::The imprinted U2af1-rs1 gene that maps to mouse chromosome 11 is predominately expressed from the paternal allele. We examined the methylation of genomic sequences in and around the U2af1-rs1 locus to establish the extent of sequence modifications that accompanied the silencing of the maternal allele. The analysis of ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0348
更新日期:1996-07-01 00:00:00
abstract::We have assigned the human tripeptidyl peptidase II (TPP2) gene to chromosome region 13q32-q33 using two different methods. First, a full-length TPP2 cDNA was used as a probe on Southern blots of DNA from a panel of human/rodent somatic cell hybrids. The TPP2 sequences were found to segregate with the human chromosome...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1353
更新日期:1993-08-01 00:00:00
abstract::One of the most critical periods of embryonic loss in pig is day 12 of pregnancy, when implantation begins. Here, we analyzed the gene expression on day 12 of pregnancy and non-pregnancy in the porcine endometrium using RNA sequencing (RNA-seq). 237 mRNAs, 34 lncRNAs and 1 miRNA were significantly differentially expre...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2016.11.007
更新日期:2017-01-01 00:00:00
abstract::A linkage analysis with chromosome 9 markers was performed in 33 families with Friedreich ataxia (FA). Linkage with D9S15, previously established by S. Chamberlain et al. (1988, Nature London 334:248-249) was confirmed in our sample (z(theta) = 6.82 at theta = 0.02) while INFB (interferon-beta gene) shows looser linka...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90323-6
更新日期:1989-01-01 00:00:00