Abstract:
BACKGROUND:The intestinal dysbiosis is common in chronic liver disease and can induce to inflammatory responses and mediate the collagen deposition in the liver. AIM:To evaluate the probiotic Lactobacillus rhamnosus GG (LGG) for the treatment of liver fibrosis in a model of chronic cholestatic liver disease in rats. METHODS:Male adult Wistar rats (n = 29) were submitted to common bile duct ligation (BDL groups) or manipulation of common bile duct without ligation (Ctrl groups).Two weeks after surgery, each group was randomly divided to receive 1 ml of PBS (Ctrl and BDL) or PBS containing 2.5 x 107 CFU of LGG (Ctrl-P and BDL-P) through gavages for 14 days. Euthanasia occurred 33 days after surgery when samples of blood and liver tissue were collected. RESULTS:The hepatic gene expression of Tlr4, Tnfα, IL-6, Tgfβ, and metalloproteinase-2 and -9 were higher in the BDL groups in comparison to Ctrl. The ductular reaction evaluated by immunocontent of cytokeratin-7 (CK7) and the content of collagen were increased in BDL groups. Also, there was an imbalance in the antioxidant defenses (superoxide dismutase and catalase) and an increase in the oxidative stress marker sulfhydryl in BDL groups. The treatment with LGG significantly reduced gene expression of IL-6, collagen deposition, and ductular reaction in hepatic tissue of animals from BDL-P groups. CONCLUSION:The treatment with the probiotic LGG was able to reduce liver fibrosis, ductular reaction, and hepatic gene expression of IL-6 in a model of cholestatic liver disease in rats.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Hammes TO,Leke R,Escobar TDC,Fracasso LB,Meyer FS,Andrades MÉ,Silveira TRDdoi
10.20960/nh.626subject
Has Abstractpub_date
2017-06-05 00:00:00pages
702-709issue
3eissn
0212-1611issn
1699-5198journal_volume
34pub_type
杂志文章abstract:INTRODUCTION:Currently, there is a higher occurrence of biopsychosocial diseases, especially eating disorders, involving different body systems and aspects related to the individual and their social relations. OBJECTIVE:Addressing current and relevant issues about the prevalence, incidence and risk factors for anorexi...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.1590/S0212-16112012000200008
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The consumption of sugary, energy and alcoholic drinks among college students might be a health risk factor. OBJECTIVE:To assess the consumption of sugary, energy and alcoholic drinks and to determine their associations with body mass index (BMI) status among college students. METHODS:Second and third year...
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
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journal_title:Nutricion hospitalaria
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:BACKGROUND:Weight is one of the most important parameters in assessing nutritional status. However, weight can be difficult to measure in elderly people who are unable to stand. Chumlea et al. created two equations to estimate weight in non-ambulatory patients using readily available body measurements. OBJECTIVE:The a...
journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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abstract::Over the last few years, a considerable amount of studies have focused on the effect of undernutrition and overnutrition during critical periods of offspring development and their risk of developing metabolic diseases later in life. Additionally, inadequate maternal diets have been involved in the malprogramming of br...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
doi:10.3305/nh.2012.27.5.5880
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The nutritional care for HIV patients in Chile is a challenge for public health due to the absence of ministerial guidelines to ensure standardized and timely nutritional care that helps to enhance immunity and delay immunological failure from a preventive approach. OBJECTIVE:To design a proposal of protoco...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.2.7888
更新日期:2014-11-18 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.1590/S0212-16112011000400003
更新日期:2011-07-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2012.27.6.6043
更新日期:2012-11-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Nutricion hospitalaria
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更新日期:2016-07-19 00:00:00
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更新日期:2014-11-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 历史文章,杂志文章
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更新日期:2019-07-02 00:00:00
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journal_title:Nutricion hospitalaria
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