[Neural pathophysiology of cancer anorexia].

Abstract:

INTRODUCTION:Approximately two thirds of cancer patients at advanced stages of the disease suffer from anorexia. Defined as the loss of the desire to eat, anorexia lower the energy intake which further exacerbates a progressive deterioration of the patient nutritional status. Malnutrition has a large impact on morbidity and mortality affecting the quality of life. Cancer anorexia etiology is multifactorial including complex interactions among the tumor, host metabolism and antineoplastic treatment. New related theories include peripheral and brain mechanisms affecting hypothalamic pathways; inducing behavioral and metabolic failure of responses to energy balance. The aim of this review is to describe actual concepts involved in the pathogenesis of cancer anorexia with special interest in brain mechanisms. CONCLUSIONS:Anorexia and reduced food intake are important issues in the management of cancer patients, more knowledge about pathogenic mechanism is needed to improve therapeutic options, prognosis and quality of life in cancer patients.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Sánchez-Lara K,Sosa-Sánchez R,Green-Renner D,Méndez-Sánchez N

doi

10.1590/S0212-16112011000400003

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

677-84

issue

4

eissn

0212-1611

issn

1699-5198

pii

S0212-16112011000400003

journal_volume

26

pub_type

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    doi:

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    pub_type: 杂志文章,随机对照试验

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  • [BREAST FEEDING AS PREVENTIVE FACTOR FOR OSTEOPOROSIS IN ADULT WOMEN].

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    doi:

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    authors: San Onofre Bernat N,Trescastro-López EM,Quiles I Izquierdo J

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    pub_type: 杂志文章,评审

    doi:

    authors: García Peris P,Velasco Gimeno C

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