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Study of hyperglycemia in non critically-ill patients receiving parenteral nutrition: incidence and risk factors.

Abstract：

BACKGROUND:The objectives of our study on non-critically ill patients receiving parenteral nutrition (PN) are to assess the incidence of hyperglycemia, the risk factors associated to its development and its influence in patient's evolution. METHODS:A multicentric prospective observational study was performed in 9 hospitals. Four multivariate studies were developed to study the temporal risk in the occurrence of hyperglycemia (endpoint), intensive care unit (ICU) admission, length of stay (LOS) and death. Demographics, nutrients, drugs and clinical variables were collected. Independent variables studied as a possible risk factors were: sex, diabetes mellitus 2, baseline glycemia, albuminemia, pancreatitis, surgery in the 7 days prior to the end point, infection, insulin/somatostatin/corticoids administration during the study, glomerular filtration rate (GFR), and difference in the amount of glucose administration between the endpoint and one day before. RESULTS:119 patients were enrolled in the study, 25 cases of hyperglycemia were detected. In the clinical factors associated with PN hyperglycemia, significant variables were: surgery in the 7 days before the end point, GFR, glucose load in the 24 hours previous to the end point insulin administration and somatostatine/octreotide administration during the study. Hyperglycemia was significantly associated with ICU admission and increased LOS. CONCLUSIONS:Glucose administration in non-critically ill patients receiving PN should be reassessed downwards, especially in the immediate postsurgery, renal impairment and in patients treated with somatostatin analogues. It should be taken into account that an increase in glucose dose may lead to hyperglycemia in these patients and hyperglycemia correlates with longer hospital stay and increased frequency of ICU admissions.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Llop JM,Leiva E,Mateu-de Antonio J,Berlana D,Badia M,Casasín T,Miana M,Pons M,Maroto M,Chicharro L,López-Suñé E,Díaz-Munio E,Sevilla D,Martínez I,Vitales M,Casajuana MT,Bobis MA

doi

10.3305/nh.2012.27.5.5880

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

1521-6

issue

eissn

0212-1611

issn

1699-5198

pii

S0212-16112012000500022

journal_volume

pub_type

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Study of hyperglycemia in non critically-ill patients receiving parenteral nutrition: incidence and risk factors.