Abstract:
:In the present study the effects of two cycloxygenase-2 (COX-2) selective inhibitors, celecoxib and nimesulide as compared to a non-selective COX inhibitor, aspirin was studied in the rat intestine. Female Wistar rats weighing between 150-175 g were divided into four groups having 8 animals each as follows: Group 1(Control), Group 2- Aspirin (40 mg/kg), Group 3- Nimesulide (10 mg/kg) and Group 4- Celecoxib (10 mg/kg). After 35 days of treatment the animals were sacrificed, intestine removed and the effects on the antioxidant defense system, membrane composition and functions along with the membrane specific enzymes were studied in different regions of the intestine. The study showed a significant increase in the lipid peroxide levels as TBA-reactive substance as well as the conjugated dienes, except for celecoxib treated group which showed a decrease. Significant decrease was also observed in the level of reduced glutathione (GSH), superoxide dismutase (SOD), glutathione-s-transferase and catalase activities for aspirin and nimesulide group while Celecoxib caused an increase in glutathione reductase (GR). Aspirin and nimesulide exhibited an increase in the brush border membrane (BBM) bound enzyme activities like sucrase, lactase, maltase and alkaline phosphatase in the small intestine while celecoxib showed decrease in lactase, maltase and alkaline phosphatase. The phospholipid content increased only for aspirin treated group while cholesterol decreased in all the treatment groups. Also celecoxib treatment brought about an increase in glycolipid content. The membrane fluidity was studied by the rotational diffusion of 1, 6, diphenyl, 1, 3, 5 hexatriene (DPH) incorporated in the membrane and the fluorescence polarization (p), fluorescence anisotropy(r), anisotropy parameter [r0/r-1](-1) and order parameter [S2 = (4/3r - 0.1)/r0] were recorded. No significant change in the fluorescence parameters were observed in the BBM and the liposomes made from the BBM lipids for the treatment groups. These results indicate that celecoxib may be accepted as a safer drug in terms of overall gastro-intestinal toxicity as compared to the aspirin and nimesulide.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Nair P,Kanwar SS,Sanyal SNsubject
Has Abstractpub_date
2006-11-01 00:00:00pages
638-49issue
6eissn
0212-1611issn
1699-5198journal_volume
21pub_type
杂志文章abstract::We have performed a clinical study involving patients with symptomatic gallstones and indications for surgery, to analyze the biliary and pancreatic response to the quality of dietary fat (degree of unsaturation). As part of the investigative method, we have designed a clinical protocol adapted to the needs of the stu...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::Dual-energy X ray absorptiometry (DEXA) is primarily used in the assessment of bone mineral. However, the transmissions of the two different energy beams in nonbone areas can be processed to calculate the amount of fat and free-fat mass of the soft tissues. We have compared the estimation of body fat mass (FM) by DEXA...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Chile has drastically altered eating patterns and physical activity. The main nutritional problem faced by Chilean society is overweight, which arises progressively from an early age. The aim of this study is to determine the nutritional status and compare fitness levels and fasting glucose in students. PAT...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.6.8932
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:breastfeeding is considered protective of osteoporosis, by endocrine changes, such as the rise of intestinal absorption of calcium and the renal conservation of the same, however, other studies demonstrate that with more one child they present a loss of bone mineral density (BMD) (2-9%). OBJECTIVE:to dete...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.32.6.9047
更新日期:2015-12-01 00:00:00
abstract::Registering the ingestive activity of laboratory animals can be carried out by using electronic scales connected to personal computers, thus gathering data files that allow calculation of the daily ingestion standards. The ingestion parameters most often used in the standard analysis include the number, size, and dura...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Oncohematological diseases such as lymphoma or leukaemia affect an increasing number of newly diagnosed patients in Spain and other countries. Both disease and treatment may have a negatively impact in the nutritional status of the patient. Malnutrition is not uncommon among oncohematological patients. This ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2012.27.3.5863
更新日期:2012-05-01 00:00:00
abstract::The modification of dietary patterns has led to a change in fatty acid consumption, with an increase in the consumption of ω-6 fatty acids and a marked reduction in the consumption of ω-3 fatty acids. This in turn has given rise to an imbalance in the ω-6/ω-3 ratio, which is now very different from the original 1:1 ra...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.1590/S0212-16112011000200013
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection may cause nutrient deficiency and affect the nutritional status.Objetive: To assess nutritional status, and energy and macronutrient intake in HCV/HIV coinfected patients. METHODS:Cross-sectional study on HIV/HCV-coinfected patient...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.576
更新日期:2016-10-18 00:00:00
abstract::Breast milk is regarded as an ideal source of nutrients for the growth and development of neonates, but it can also be a potential source of pollutants. Mothers can be exposed to different contaminants as a result of their lifestyle and environmental pollution. Mercury (Hg) and arsenic (As) could adversely affect the ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2014.30.2.7441
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Obesity and the metabolic syndrome affect a considerable segment of the population worldwide, including health professionals. In fact, several studies have reported that physicians tend to have more cardiovascular risk factors than their patients. The present cross-sectional study assessed whether the Health...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.1.6185
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To design a self-reported semi-quantitative questionnaire of frequency of food intake (QFFI) to assess the usual intake of foods and macronutrients of the academic community from the University of Antioquia (UoA). METHODOLOGY:The design of the questionnaire was done by reviewing and analyzing previous studie...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000600021
更新日期:2011-11-01 00:00:00
abstract:Introduction:Introduction: currently, it is important to determine whether food frequency questionnaires (FFQ) are valid tools to collect information on usual diet in children. Objective: we evaluated the reproducibility and validity of the semi-quantitative FFQ used in a Spanish cohort of children aged 4-7 years. Meth...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.03003
更新日期:2020-08-27 00:00:00
abstract:INTRODUCTION:Evidences suggest that fat intake, visceral obesity and intracellular lipids are related to insulin impairment. OBJECTIVE:The objective of the present paper was correlate visceral obesity and metabolic alterations in control (CTR) and hyperlipidic cafeteria diet (CFT) fed animals. METHODS:After 6 months ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2013.28.2.6181
更新日期:2013-03-01 00:00:00
abstract::An important area of the development of new functional foods is facussed on finding or applying food components which favour achieving a healthier lipid profile in the organism. The objective of this work was to carry out the characterisation of the lipid fraction of two oils, fish oil and algae oil, to evaluate their...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the association of overweight and obesity with insulin resistance, hypertension, and hyperlipidemic among 12 to 15 year olds from private and public schools in Chiapas. METHODS:This was a cross-sectional study with a random selection of 259, 12 to 15 year old teenagers fro...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To check the correlation between gastric intolerance and hypertension intracranial pressure and their association with the clinical parameters and severity indexes in patients with severe head injury (HI); to evaluate the advantages of transpyloric feeding. DESIGN:Prospective and observational clinical study...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract:INTRODUCTION:Currently, there is a higher occurrence of biopsychosocial diseases, especially eating disorders, involving different body systems and aspects related to the individual and their social relations. OBJECTIVE:Addressing current and relevant issues about the prevalence, incidence and risk factors for anorexi...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.1590/S0212-16112012000200008
更新日期:2012-03-01 00:00:00
abstract::One of the generic indications of parenteral peripheral malnutrition is the immediate postoperative period following surgery of the digestive tract. In the series presented, fifty patients with digestive neoplasia of different locations were studied, with slight or moderate malnutrition upon admittance. After the oper...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract:UNLABELLED:The National Survey of Family Income and Expenditure (ENIGFAM 2009-2010), showed that a third, and almost two thirds of Guatemalans purchased outside the home breakfast and lunch. OBJECTIVE:To determine the composition, nutritional value and price of breakfast and lunch menus purchased outside the home in u...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.2.7752
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:Health education is one of the primary tools for health promotion, especially for those that will be responsible for educating on healthy habits in the future. OBJECTIVE:To improve healthy lifestyle habits in university students through an educational intervention based on gamification. METHOD:A cuasiexp...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.669
更新日期:2017-07-28 00:00:00
abstract:BACKGROUND:residents are vulnerable to suffer of dehydration due to physiological changes and the physical and cognitive limitations. AIM:to handle this situation, it has been decided to evaluate the interventions which are carried out for the management of dehydration and low fluid intake in older people living in nu...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.1885
更新日期:2018-12-03 00:00:00
abstract:OBJECTIVE:To evaluate whether more positive self-perception of physical fitness is associated with lower prevalence of metabolic syndrome (MetS) and its components in university students in Bogotá, Colombia Method: A total of 493 men (mean age 28.5±11.5 years old) without cardiovascular disease university students comp...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.3305/nh.2015.31.3.8398
更新日期:2014-12-17 00:00:00
abstract::Obesity and breast cancer are two very frequent pathologies in the world today, which have a strong impact on society. Various research studies have tried linking the two. For this purpose, data was collected from the medical histories of 524 women who had been diagnosed and treated for breast cancer from January 2009...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.1590/S0212-16112011000400033
更新日期:2011-07-01 00:00:00
abstract::During the last half of the 20th century, Nutrition has evolved in a quick way based on the knowledge of both basic sciences as Biochemistry and Physiology and applied sciences as Epidemiology and Public Health. In that period the nutritional requirements for different population groups grouped by sex, age and physiol...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.20960/nh.2123
更新日期:2018-06-12 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Various experimental studies have shown that a deficient intake of zinc increases the proliferation of cells, the effect of carcinogens and the progression of colonic adenomas to carcinomas. The purpose of our study is to determine whether this relationship between zinc intake deficit and co...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract:Introduction:Introduction: socio-economic differences lead to food and nutritional inequalities. Diet is a modifiable risk factor by public health activities, on the way to the prevention of chronic non-communicable diseases. Objective: to estimate food inequalities in Argentina based on the socioeconomic level of the ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:10.20960/nh.02828
更新日期:2020-02-17 00:00:00
abstract:BACKGROUND:The objective of this study, focused on parents and children to reduce sedentary behavior, consumption of soft drinks and high-fat and salt containing snacks, and increase the consumption of fruits and vegetables, was to assess the effect of a six month intervention and an 18 month follow-up intervention on ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,随机对照试验
doi:10.3305/nh.2012.27.3.5756
更新日期:2012-05-01 00:00:00
abstract::The existence of interactions between different drugs or between drugs and the diet is becoming better and better known. Statins are medicines currently in widespread use for the treatment of hyperlipidaemias. Diet has a great influence on the prevention and/or treatment of these pathologies as the therapeutic strateg...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
更新日期:2004-07-01 00:00:00
abstract::Nutrition, physical activity and behavior-modifying techniques are widely applied components of interventions treating obesity. Our aim was to review available information on the short and long term effects of intervention treatment on body fat composition of overweight and obese children and adolescents and, to obtai...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
doi:10.3305/nh.2013.28.1.6264
更新日期:2013-01-01 00:00:00
abstract::Enterocutaneous fistula is the most common of all intestinal fistulas. Is a condition that requires prolonged hospital stay due to complications such as electrolyte imbalance, malnutrition, metabolic disorders and sepsis. Nutritional support is an essential part of the management; it favors intestinal and immune funct...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:10.3305/nh.2014.29.1.6891
更新日期:2014-01-01 00:00:00