Chemical composition and antifungal activity of essential oil from Eucalyptus smithii against dermatophytes.

Abstract:

INTRODUCTION:In this study, we evaluated the chemical composition of a commercial sample of essential oil from Eucalyptus smithii R.T. Baker and its antifungal activity against Microsporum canis ATCC 32903, Microsporum gypseum ATCC 14683, Trichophyton mentagrophytes ATCC 9533, T. mentagrophytes ATCC 11480, T. mentagrophytes ATCC 11481, and Trichophyton rubrum CCT 5507. METHODS:Morphological changes in these fungi after treatment with the oil were determined by scanning electron microscopy (SEM). The antifungal activity of the oil was determined on the basis of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values. RESULTS:The compound 1,8-cineole was found to be the predominant component (72.2%) of the essential oil. The MIC values of the oil ranged from 62.5μg·mL-1 to >1,000μg·mL-1, and the MFC values of the oil ranged from 125μg·mL-1 to >1,000μg·mL-1. SEM analysis showed physical damage and morphological alterations in the fungi exposed to this oil. CONCLUSIONS:We demonstrated the potential of Eucalyptus smithii essential oil as a natural therapeutic agent for the treatment of dermatophytosis.

journal_name

Rev Soc Bras Med Trop

authors

Baptista EB,Zimmermann-Franco DC,Lataliza AA,Raposo NR

doi

10.1590/0037-8682-0188-2015

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

746-52

issue

6

eissn

0037-8682

issn

1678-9849

pii

S0037-86822015000600746

journal_volume

48

pub_type

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