Adult T-cell leukemia/lymphoma: report of two cases.

Abstract:

:Adult T-cell leukemia/lymphoma is a lymphoproliferative disorder of mature T lymphocytes associated with infection with human T-cell lymphotrophic virus type I (HTLV-I). Adult T-cell leukemia/lymphoma is characterized by clinical and laboratory polymorphism that allows it to be classified into four distinct subgroups: smoldering, chronic, acute and lymphomatous types. We present here two cases of adult T-cell leukemia/lymphoma, respectively in the acute and lymphomatous forms of the disease. Case 1 was a 35-year-old woman who presented abdominal distension accompanied by hepatosplenomegaly, adenomegaly, skin lesions, positivity for anti-HTLV-I antibodies and leukocytosis with the presence of flower cells. Case 2 was a 38-year-old man who was admitted with generalized lymphadenomegaly, positivity for anti-HTLV-I antibodies, hypercalcemia and osteolytic lesions. In this paper, we correlate the clinical-laboratory findings of these two cases with data in the literature.

journal_name

Rev Soc Bras Med Trop

authors

Olivo RA,Martins FF,Soares S,Moraes-Souza H

doi

10.1590/s0037-86822008000300012

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

288-92

issue

3

eissn

0037-8682

issn

1678-9849

pii

S0037-86822008000300012

journal_volume

41

pub_type

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