Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment.

Abstract:

:Mice previously infected with Schistosoma mansoni, and cured by specific treatment (400mg/kg oxamniquine, p.o.) in the chronic phase of the disease, were reinfected 20 days after treatment to assess their capacity for modulation of the granulomatous response. Histopathologic examination of the animals' liver, at 60 days after reinfection, evidenced the presence of typical granulomas of the chronic phase in most animals. This infer that the capacity for modulation of the granulomatous response had been maintained, thus preventing a new acute phase of the disease. Conversely, a group of previously infected mice, untreated and submitted to reinfection, showed reactivation of the granulomatous response in 50% of the animals. The possible implications of these findings in human schistosomiasis mansoni are discussed.

journal_name

Rev Soc Bras Med Trop

authors

Coelho PM,Raso P,de Mello RT,Toppa NH

doi

10.1590/s0037-86821994000300001

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

119-25

issue

3

eissn

0037-8682

issn

1678-9849

journal_volume

27

pub_type

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