Mycobacterium tuberculosis spoligotypes and drug-resistant characterization from Beira compared to genotypes circulating in Mozambique.

Abstract:

INTRODUCTION:Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambique comparing them with genotypes in the country. METHODS:We performed spoligotyping of 79 M. tuberculosis suspected of DR-TB compared all spoligotype patterns published on the international database and PubMed. RESULTS:Both in Beira and Mozambique (n=578), the main clades were Latin-American-Mediterranean, East-African-Indian, Beijing and T, with no extensively DR TB cases. CONCLUSIONS:Beira and Mozambique share the same population genetic structure of M. tuberculosis.

journal_name

Rev Soc Bras Med Trop

authors

Anselmo LMP,Conceição EC,Namburete E,Feliciano C,Spindola S,Sola C,Bollela VR

doi

10.1590/0037-8682-0257-2019

subject

Has Abstract

pub_date

2019-11-25 00:00:00

pages

e20190257

eissn

0037-8682

issn

1678-9849

pii

S0037-86822019000100693

journal_volume

52

pub_type

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