There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment.

Abstract:

INTRODUCTION::We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis. METHODS::This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression. RESULTS::There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment. CONCLUSIONS::There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.

journal_name

Rev Soc Bras Med Trop

authors

Silva PC,Silva AV,Silva TN,Vasconcelos LM,Gomes AV,Coêlho MR,Muniz MT,Domingues AL

doi

10.1590/0037-8682-0141-2016

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

781-785

issue

6

eissn

0037-8682

issn

1678-9849

pii

S0037-86822016000600781

journal_volume

49

pub_type

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