Abstract:
INTRODUCTION:Amphotericin B, azole or sulfamide drugs are used for treatment of patients with paracoccidioidomycosis. Among the azole drugs, voriconazole was active in vitro against Paracoccidioides brasiliensis and showed efficacy in the treatment of patients infected with this fungus.In the present study the antifungal activity of voriconazole and of other drugs was compared in a rat model of paracoccidioidomycosis. METHODS:Wistar rats were inoculated intravenously with the BOAS strain of P. brasiliensis and antifungal drugs were administered to the animals by gavage at the following doses (mg/kg weight/day): voriconazole (5 to 20), ketoconazole (12 to 15), fluconazole (6), itraconazole (4), and sulfamethoxazole-trimethoprim (120 to 150). The antifungal activity of the drugs was assessed by determining the P. brasiliensis colony forming units in the lungs and spleen of the animals at the end of treatment and by a survival study. RESULTS:Voriconazole reduced the total tissue fungal burden of P. brasiliensis, particularly at doses of ≥ 10 mg/kg weight/day but its antifungal activity was less intense than that of fluconazole, itraconazole and sulfamethoxazole-trimethoprim. The mean survival of animals treated with the last three drugs, 29.1 ± 10.7, 26.1 ± 10.1 and 28.4 ± 9.6 days, respectively, was higher than that achieved with voriconazole 10mg/kg weight/day (18.5 ± 8.3 days) and that observed in untreated animals (15.7 ± 3.6 days). CONCLUSIONS:At doses similar to those used for clinical treatment, voriconazole showed lower antifungal activity in experimental rat paracoccidioidomycosis than that obtained with itraconazole and sulfamethoxazole-trimethoprim.
journal_name
Rev Soc Bras Med Tropjournal_title
Revista da Sociedade Brasileira de Medicina Tropicalauthors
Granzoto DS,Vitali LH,Martinez Rsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
79-83issue
1eissn
0037-8682issn
1678-9849pii
S0037-86822013000100079journal_volume
46pub_type
杂志文章abstract:INTRODUCTION:Bacterial meningitis has great social relevance due to its ability to produce sequelae and cause death. It is most frequently found in developing countries, especially among children. Meningococcal meningitis occurs at a high frequency in populations with poor living conditions. This study describes the te...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822012000300009
更新日期:2012-06-01 00:00:00
abstract::Clinical and serological follow-up of 7 patients submitted to renal transplantation and presenting positive serological reactions to Chagas' disease before immunosuppression did not show significant changes in indirect immunofluorescence and complement fixation titres for Chagas' disease, or signs and symptoms indicat...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821993000400002
更新日期:1993-10-01 00:00:00
abstract::An occurrence of pruritic papular dermatitis among the whole crew of a Filipino commercial ship in Salvador, State of Bahia, was associated with contact with Hylesia moths. This unusual type of dermatitis is caused by the bristles (flechettes) on the moths' bodies. Reporting on such cases serves to warn about possible...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822007000500020
更新日期:2007-09-01 00:00:00
abstract::We herein report human dermatitis caused by the tropical fowl mite Ornithonyssus bursa (Berlese). The cases occurred in an apartment in a residential district of Porto Alegre City, State of Rio Grande do Sul, Brazil, where three members of the same family presented with pruritic lesions on the arms and legs. On inspec...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0170-2015
更新日期:2015-11-01 00:00:00
abstract:INTRODUCTION:This paper presents the results of an extensive survey of freshwater mollusks in the Simplício Queda Única Hydroelectric Development area, Southeast Brazil. METHODS:Mollusks were collected between 2008 and 2013. All specimens were examined for the presence of larval trematodes. RESULTS:In total, 12,507 s...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0334-2017
更新日期:2018-09-01 00:00:00
abstract::An epidemiological survey was carried out in 3,344 people of an urban town in Lagamar, Minas Gerais, Brazil--during 1992-1993, to evaluate the main risk factors related to taeniasis and cysticercosis. A total number of 875 (78.9%) houses were visited and 1080 (32.3%) subjects were clinically examined. Poor sanitary co...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821998000100009
更新日期:1998-01-01 00:00:00
abstract::From a canine case of american cutaneous leishmaniasis in the locality of Santa Rita de Cássia, municipality of Barra Mansa, Rio de Janeiro, a serological survey was performed on 177 dogs and 43 cats. Evaluation of the canine serum samples showed that 10% had a positive reaction in the indirect immunofluorescence test...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822009000200009
更新日期:2009-03-01 00:00:00
abstract::The authors presented a detailed review about the treatment of bancroftian filariasis with diethylcarbamazine. The interesting aspects about the drug discovery and the basic concepts about its pharmacology were reported in a summarised form. On the other hand, emphasis was made about the speculation done by several au...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,评审
doi:10.1590/s0037-86821997000300010
更新日期:1997-05-01 00:00:00
abstract:INTRODUCTION:Coronavirus disease 2019 (COVID-19), a potentially fatal disease, is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The number of cases has increased rapidly, but information on the clinical characteristics remains limited. METHODS:Cohort study. We collected and analyzed epide...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0579-2020
更新日期:2020-11-25 00:00:00
abstract::We report a case of intestinal involvement of Paracoccidioidomycosis, in a patient considered to have colonic cancer. The diagnosis of this mycosis should be considered when an abdominal mass associated with intra-lesional calcifications on X-ray is observed. CT scans increase the findings. ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,评审
doi:10.1590/s0037-86822000000300010
更新日期:2000-05-01 00:00:00
abstract:INTRODUCTION:Bacterial translocation is the invasion of indigenous intestinal bacteria through the gut mucosa to normally sterile tissues and internal organs. Schistosomiasis may cause alterations in the immune system and damage to the intestines, portal system and mesenteric lymph nodes. This study investigated bacter...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0042-2015
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:Low handgrip strength (HS) is associated with cardiometabolic alterations that have affected people with HIV/AIDS. METHODS:This was a cross-sectional study performed in adults receiving antiretroviral treatment. HS was evaluated using a dynamometer and divided by body weight to obtain the relative strengt...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0405-2018
更新日期:2019-05-16 00:00:00
abstract:INTRODUCTION:Immunization is the primary method of preventing influenza. The objective of this study was to describe reasons and determine causes of acceptance or refusal of the influenza vaccine by elderly people. METHODS:This cross-sectional and descriptive study included elderly patients (aged >60 years) from the C...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0366-2018
更新日期:2019-03-14 00:00:00
abstract:INTRODUCTION:Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambique comparing them with geno...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0257-2019
更新日期:2019-11-25 00:00:00
abstract::A case of larva migrans or serpiginous linear dermatitis on the scalp of a teenager is reported. An ancylostomid larva was found within a sebaceous gland acinus. The unusual skin site for larva migrans as well as the penetration through the sebaceous gland are highlighted. The probable mechanism by which the parasite ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,评审
doi:10.1590/s0037-86821999000200011
更新日期:1999-03-01 00:00:00
abstract::780 patients with recurrent conjunctival infections or persistent complaints of itching, burning pain, lacrimation and conjunctival hyperemia were subject to conjunctival smear examination for cytology and the presence of inclusion bodies. Two hundred and forty seven (31.7%) showed cytoplamic inclusions; 235 of them w...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821990000100006
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:This study aimed to confirm the identification of Enterococcus gallinarum and Enterococcus casseliflavus isolated from clinical and food samples by PCR-RFLP. METHODS:Fifty-two strains identified by conventional biochemical exams were submitted to PCR amplification and digested with HinfI. Only 20 (38.5%) ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822010000100023
更新日期:2010-01-01 00:00:00
abstract::Chagas Disease is caused by Trypanosoma cruzi. This infection is endemic in the Americas region. Neurological Chagas reactivation is diagnosed through the visualization of the parasite in the cerebrospinal fluid, blood, or tissue samples. Herein, we report the visualization of trypomastigotes by direct microscopic obs...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type:
doi:10.1590/0037-8682-0326-2020
更新日期:2020-12-21 00:00:00
abstract::In 30 patients with foliaceus pemphigus the frequency of strongyloidiasis was 40%, by three Baermann-Moraes examination. In the "Hospital do Pênfigo", for patients with pemphigus of Uberaba, the frequencies of strongyloidiasis in the employees (n = 14) and students (n = 47), of the annexed nursery, also were high, res...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821991000300004
更新日期:1991-07-01 00:00:00
abstract::From September to November 1994. 21 patients with active mucosal leishmaniasis were treated with aminosidine sulphate 16 mg/kg/day by intramuscular injection for 20 days. They were principally adult male agricultural workers. Thirteen patients had not received specific treatment and eight had failed to respond to Gluc...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821996000600005
更新日期:1996-11-01 00:00:00
abstract::This study aimed to evaluate the second-generation OptiMal test for malaria diagnosis under various storage conditions. It detected all the positive samples, except for two Plasmodium malariae samples. Further research evaluating diverse environmental conditions are important for ICT test applicability in Brazilian ma...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822005000200015
更新日期:2005-03-01 00:00:00
abstract::A seven-year-old boy treated with ceftriaxone for meningitis who presented a right upper quadrant abdominal pain associated with cholelithiasis. After three months he was symptom-free and abdominal ultrasonography was normal. Awareness of this phenomenon is highly important and can save many unnecessary cholecystectom...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822005000600014
更新日期:2005-11-01 00:00:00
abstract:INTRODUCTION:Triatomines are targeted for the control of Chagas disease in endemic areas of Brazil. METHODS:Data regarding triatomines captured during 2001-2008 in 34 municipalities in the Northeast of Minas Gerais were analyzed. RESULTS:In total, 11,187 triatomines from eight species were captured, mostly in henhous...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0142-2016
更新日期:2016-07-01 00:00:00
abstract:INTRODUCTION:Cryptococcosis is the second most frequent cause of opportunistic infections in human immunodeficiency virus (HIV) patients in Colombia. We aimed to determine the prevalence of cryptococcosis in the Colombian department of Atlántico. METHODS:An active search for cryptococcosis cases was conducted between ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0194-2018
更新日期:2019-04-25 00:00:00
abstract:INTRODUCTION:The genera Enterococcus, Staphylococcus and Streptococcus are recognized as important Gram-positive human pathogens. The aim of this study was to evaluate the performance of Vitek 2 in identifying Gram-positive cocci and their antimicrobial susceptibilities. METHODS:One hundred four isolates were analyzed...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0123-2013
更新日期:2014-05-01 00:00:00
abstract::Between 2000 and 2004, a survey of Triatominae fauna (Hemiptera: Reduviidae) and examination of natural infection caused by Trypanosomatidae in the State of Mato Grosso do Sul, Brazil, was conducted. A total of 13,671 specimens were collected. Through fauna analysis on the insects that were caught, Triatoma sordida wa...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822008000400010
更新日期:2008-07-01 00:00:00
abstract:INTRODUCTION:Rapid diagnostic tests (RDTs) are selected based on their performances. Here, we compared the diagnostic performance of different malaria RDTs. METHODS:Febrile patients were tested for malaria using Vikia Malaria Pf/Pan, Meriline-Meriscreen Pf/Pv/Pan, Right Sign Malaria Pf/Pan, and Right Sign Malaria Pf R...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0274-2019
更新日期:2020-06-22 00:00:00
abstract::In vivo antimalarial drug efficacy studies of uncomplicated Plasmodium falciparum malaria at an isolated site in the Amazon basin of Peru bordering Brazil and Colombia showed >50% RII/RIII resistance to sulfadoxine-pyrimethamine but no evidence of resistance to mefloquine. ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822004000300015
更新日期:2004-05-01 00:00:00
abstract::Two hundred and thirty-three cases of the acute phase of Chagas disease, from Pará, Amapá and Maranhão, were observed between 1988 and 2005. One hundred and sixty were studied retrospectively from 1988 to 2002 and seventy-three were prospectively followed up from 2003 to 2005. Among the cases studied, 78.5% (183/233) ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822008000600011
更新日期:2008-11-01 00:00:00
abstract::Cats are the definitive hosts of Toxoplasma gondii. Infected cats excrete oocysts in their feces, infecting humans and other animals. The objective of the present study was to determine the presence of anti-Toxoplasma antibodies in cat owners and their pets, and determine if there was a relationship between Toxoplasma...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821999000500003
更新日期:1999-09-01 00:00:00