Post-splenectomy infections in chronic schistosomiasis as a consequence of bacterial translocation.

Abstract:

INTRODUCTION:Bacterial translocation is the invasion of indigenous intestinal bacteria through the gut mucosa to normally sterile tissues and internal organs. Schistosomiasis may cause alterations in the immune system and damage to the intestines, portal system and mesenteric lymph nodes. This study investigated bacterial translocation and alterations in the intestinal microbiota and mucosa in schistosomiasis and splenectomized mice. METHODS:Forty female 35-day-old Swiss Webster mice were divided into the following four groups with 10 animals each: schistosomotic (ESF), splenectomized schistosomotic (ESEF), splenectomized (EF) and control (CF). Infection was achieved by introduction of 50 Schistosoma mansoni (SLM) cercariae through the skin. At 125 days after birth, half of the parasitized and unparasitized mice were subjected to splenectomy. Body weights were recorded for one week after splenectomy; then, the mice were euthanized to study bacterial translocation, microbiota composition and intestinal morphometry. RESULTS:We observed significant reductions in the weight increases in the EF, ESF and ESEF groups. There were increases of at least 1,000 CFU of intestinal microbiota bacteria in these groups compared with the CF. The EF, ESF and ESEF mice showed decreases in the heights and areas of villi and the total villus areas (perimeter). We observed frequent co-infections with various bacterial genera. CONCLUSIONS:The ESEF mice showed a higher degree of sepsis. This finding may be associated with a reduction in the immune response associated with the absence of the spleen and a reduction in nutritional absorption strengthened by both of these factors (Schistosoma infection and splenectomy).

journal_name

Rev Soc Bras Med Trop

authors

Lima Kde M,Negro-Dellacqua M,Dos Santos VE,de Castro CM

doi

10.1590/0037-8682-0042-2015

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

314-20

issue

3

eissn

0037-8682

issn

1678-9849

pii

S0037-86822015000300314

journal_volume

48

pub_type

杂志文章
  • Comparison of in vitro activity of five antifungal agents against dermatophytes, using the agar dilution and broth microdilution methods.

    abstract::The purpose of this study was to compare the agar dilution and broth microdilution methods for determining the minimum inhibitory concentration (MIC) of fluconazole, itraconazole, ketoconazole, griseofulvin and terbinafine for 60 dermatophyte samples belonging to the species Trichophyton rubrum, Trichophyton mentagrop...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822009000300003

    authors: Mota CR,Miranda KC,Lemos Jde A,Costa CR,Hasimoto e Souza LK,Passos XS,Meneses e Silva H,Silva Mdo R

    更新日期:2009-05-01 00:00:00

  • [Geographical expansion of visceral leishmaniasis in the State of Pernambuco].

    abstract::This study aimed to demonstrate the geographical expansion of visceral leishmaniasis in Pernambuco State, Brazil. With data on the number of visceral leishmaniasis cases notified from 1990 to 2001, maps showing the biannual evolution of the geographical distribution of the disease per municipality were elaborated. A m...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822006000400007

    authors: Dantas-Torres F,Brandão-Filho SP

    更新日期:2006-07-01 00:00:00

  • [Malnutrition and hypovitaminosis A in AIDS patients].

    abstract::Anthropometric measurements and biochemical determinations were performed on HIV-infected individuals and on patients with AIDS from the Ribeirão Preto region, SP, Brazil, in order to evaluate their nutritional and vitamin A status. Plasma retinol was measured by HPLC, and hepatic vitamin A stores were evaluated by th...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86821999000200001

    authors: Silveira SA,Figueiredo JF,Jordão Júnior A,de Unamuno Mdo R,Rodrigues M deL,Vannucchi H

    更新日期:1999-03-01 00:00:00

  • American tripanosomiasis: a study on the prevalence of Trypanosoma cruzi and Trypanosoma cruzi-like organisms in wild rodents in San Luis province, Argentina.

    abstract:INTRODUCTION:Chagas disease is caused by Trypanosoma cruzi. Wild and perianthropic mammals maintain the infection/transmission cycle, both in their natural habitat and in the peridomestic area. The aim of this paper was to present the results from a study on wild rodents in the central and northern regions of San Luis ...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822010000300007

    authors: Brigada AM,Doña R,Caviedes-Vidal E,Moretti E,Basso B

    更新日期:2010-05-01 00:00:00

  • [American cutaneous leishmaniasis: phlebotomine transmission area in the Municipality of Uberlândia, MG].

    abstract::From May 2000 to January 2001 four, 15 hour-long collections of phlebotomine were done to the insect monitoring. The collection was done in an area of infection of American cutaneous leishmaniasis in the basin of the Araguari River in the municipality of Uberlandia (MG). The first collection was made in May (a cold, d...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822005000100005

    authors: Lemos JC,Lima Sdo C

    更新日期:2005-01-01 00:00:00

  • [Serological evaluation for detection of anti-Leishmania antibodies in dogs and cats in the district of Santa Rita de Cássia, municipality of Barra Mansa, State of Rio de Janeiro].

    abstract::From a canine case of american cutaneous leishmaniasis in the locality of Santa Rita de Cássia, municipality of Barra Mansa, Rio de Janeiro, a serological survey was performed on 177 dogs and 43 cats. Evaluation of the canine serum samples showed that 10% had a positive reaction in the indirect immunofluorescence test...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822009000200009

    authors: Figueiredo FB,Bonna IC,Nascimento LD,Costa Td,Baptista C,Pacheco TM,Amendoeira MR,Madeira Mde F

    更新日期:2009-03-01 00:00:00

  • [American tegumentary leishmaniasis in the northeastern state of São Paulo-Brazil].

    abstract::An outbreak of American Cutaneous Leishmaniasis (ACL) occurring in the Northeast region of São Paulo state in 1992 is described. After the notification of the 12 human cases, a skin test survey of the local population was carried out in a rural area of the Itupeva municipality. The survey consisted of 144 interviews a...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86821995000300013

    authors: Pignatti MG,Mayo RC,Alves MJ,Souza SS,Macedo F,Pereira RM

    更新日期:1995-07-01 00:00:00

  • Longitudinal study of the indirect immunofluorescence and complement fixation tests for diagnosis of Chagas' disease in immunosuppressed patients submitted to renal transplantation.

    abstract::Clinical and serological follow-up of 7 patients submitted to renal transplantation and presenting positive serological reactions to Chagas' disease before immunosuppression did not show significant changes in indirect immunofluorescence and complement fixation titres for Chagas' disease, or signs and symptoms indicat...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86821993000400002

    authors: Figueiredo JF,Fiorillo AM,Ferraz AS

    更新日期:1993-10-01 00:00:00

  • [Epidemiological features of multidrug-resistant tuberculosis in a reference service in São Paulo city].

    abstract::In order to study certain epidemiological features of multidrug-resistant tuberculosis (MDR-TB) carriers and their influence on the control and treatment, a group of patients was evaluated over a four-year period, selected by: Mycobacterium tuberculosis isolation from sputum; resistance to Rifampin, Isoniazid and one ...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:

    authors: de Melo FA,Afiune JB,Ide Neto J,de Almeida EA,Spada DT,Antelmo AN,Cruz ML

    更新日期:2003-01-01 00:00:00

  • [Aspects of the ecology and behaviour of phlebotomines in endemic area for visceral leishmaniasis in State of Minas Gerais].

    abstract::Studies on the behavioral and feeding habits of some species of phlebotominae sand flies have contributed to the comprehension of the epidemiology of leishmaniasis. In the present work, systematic captures were performed monthly in the municipality of Porteirinha (MG) using 28 light traps (CDC) from January to Decembe...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822005000500012

    authors: Barata RA,França-Silva JC,Mayrink W,Silva JC,Prata A,Lorosa ES,Fiúza JA,Gonçalves CM,Paula KM,Dias ES

    更新日期:2005-09-01 00:00:00

  • Intestinal paracoccidioidomycosis simulating colon cancer.

    abstract::We report a case of intestinal involvement of Paracoccidioidomycosis, in a patient considered to have colonic cancer. The diagnosis of this mycosis should be considered when an abdominal mass associated with intra-lesional calcifications on X-ray is observed. CT scans increase the findings. ...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章,评审

    doi:10.1590/s0037-86822000000300010

    authors: Chojniak R,Vieira RA,Lopes A,Silva JC,Godoy CE

    更新日期:2000-05-01 00:00:00

  • First report of Panstrongylus lignarius (Walker, 1873) (Hemiptera: Reduviidae: Triatominae) in the State of Acre, Brazil.

    abstract:INTRODUCTION:This communication reports the first occurrence of Panstrongylus lignarius in the State of Acre, Brazil. METHODS:A specimen of P. lignarius was collected from a residence in a rural area of the municipality of Rio Branco, Acre, Western Amazon. RESULTS:This new report of P. lignarius extends the distribut...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/0037-8682-0307-2018

    authors: Ribeiro MAL,Castro GVS,Souza JL,Cardoso ADS,Madeira FP,Camargo LMA,Meneguetti DUO

    更新日期:2019-03-18 00:00:00

  • [Iron status, malnutrition and acute phase response in HIV-positive patients].

    abstract::Nutritional status and some iron metabolism parameters of acute phase response (APR) positive and APR-negative AIDS patients were studied. Twenty-nine AIDS patients were submitted to 24h food intake recall, anthropometry, and albumin, C-reactive protein (CRP), hemoglobin, ferritin, and total iron binding capacity (TIB...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822000000200003

    authors: Monteiro JP,Cunha DF,da Cunha SF,dos Santos VM,Silva-Vergara ML,Correia D,Bianchi ML

    更新日期:2000-03-01 00:00:00

  • Diversity and dynamics of airborne fungi in São Luis, State of Maranhão, Brazil.

    abstract:INTRODUCTION:This study aimed to identify airborne fungi in São Luis, Maranhão, Brazil, to determine the prevalent genera and to correlate these genera with the area and season. METHODS:In total, 1,510 colony-forming units (CFUs) of airborne fungi were isolated from the north, south, east and west sides and from the c...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/0037-8682-0229-2013

    authors: Bezerra GF,Gomes SM,Neto Silva MA,Santos RM,Filho Muniz WE,Viana GM,Nascimento Mdo D

    更新日期:2014-01-01 00:00:00

  • Twenty-eight years of Aedes albopictus in Brazil: a rationale to maintain active entomological and epidemiological surveillance.

    abstract:INTRODUCTION:Aedes albopictus was first detected in Brazil in 1986. This mosquito species presents a major threat to public health because Brazilian populations have shown substantial vector competence for arboviruses such as dengue and chikungunya. METHODS:We updated the records of Ae. albopictus in several States of...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/0037-8682-0155-2014

    authors: Pancetti FG,Honório NA,Urbinatti PR,Lima-Camara TN

    更新日期:2015-01-01 00:00:00

  • [Determination of antistreptolysin "O" and C-reactive protein among school children of Laranjal, PR].

    abstract::For antistreptolysin "O" and C-reactive protein determination, carried out in Laranjal-PR, we analyzed the serum of 411 school children aged from 5 to 16. For antistreptolysin O, 13.6% had elevated titers and 5.1% were reactive for C-reactive protein. No differences related to age or sex were observed. ...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822005000100015

    authors: Prestes-Carneiro LE,Acêncio Edos S,Pompei AC

    更新日期:2005-01-01 00:00:00

  • [Effects of maternal infection with Trypanosoma cruzi in pregnancy development and in the newborn infant].

    abstract::In the endemic regions of Bolivia the infection of the feminine population in fertile age by T. cruzi is frequent (20 to 50 % of the women in fertile age) and the rate of fetal maternal transmission is of approximately 5%. A great percentage of infected women do not transmit the infection to the fetus. The intention o...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:

    authors: Torrico F,Castro M,Solano M,Rodriguez P,Torrico MC,Truyens C,Carlier Y

    更新日期:2005-01-01 00:00:00

  • [Prevalence of antibodies against Yersinia pestis in domestic carnivores, in plague foci in the State of Ceará].

    abstract::The prevalence of antibodies against Yersinia pestis in domestic carnivores (dogs and cats), in plague areas in the State of Ceará, was analyzed to establish the importance of monitoring these animals within the routine practice of the plague control program. Over the decade 1997-2006, 146,732 serum samples were exami...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822009000600019

    authors: Aragão AI,Pinheiro KM,Seoane AC,Tavares C,Almeida AM

    更新日期:2009-11-01 00:00:00

  • Comparative analysis of Mouse Inoculation Test and Virus Isolation in Cell Culture for rabies diagnosis in animals of Parana, Brazil.

    abstract:INTRODUCTION:Rabies is an acute zoonotic disease, caused by a rhabdovirus that can affect all mammals, and is commonly transmitted by the bite of a rabid animal. The definitive diagnosis is laboratorial, by the Fluorescent Antibody Test (FAT) as a quick test and Mouse Inoculation Test (MIT) as a confirmatory test (gold...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/0037-8682-0303-2017

    authors: Corona TF,Böger B,Rocha TCD,Svoboda WK,Gomes EC

    更新日期:2018-01-01 00:00:00

  • Epidemiological aspects of human and canine visceral leishmaniasis in Montes Claros, State of Minas Gerais, Brazil, between 2007 and 2009.

    abstract:INTRODUCTION:Visceral leishmaniasis (VL) is an expanding zoonosis in Brazil and is becoming urbanized in several Brazilian regions. This study aims to describe the epidemiological features of human and canine VL in the municipality of Montes Claros, State of Minas Gerais, by focusing on their spatial distribution. MET...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822011000500006

    authors: Prado PF,Rocha MF,Sousa JF,Caldeira DI,Paz GF,Dias ES

    更新日期:2011-10-01 00:00:00

  • Therapeutic drug monitoring of benznidazole and nifurtimox: a systematic review and quality assessment of published clinical practice guidelines.

    abstract::The pharmacological management of adults with chronic-phase Chagas disease is challenging despite it being the recent focus of extensive research. One of the challenges in the current clinical practice guidelines (CPGs) landscape is the existence of non-evidence-based recommendations for the use of laboratory tests in...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章,评审

    doi:10.1590/0037-8682-0399-2016

    authors: Olivera MJ,Fory JA,Olivera AJ

    更新日期:2017-11-01 00:00:00

  • Seroprevalence of Neospora caninum and Toxoplasma gondii in dogs from an urban area of North-eastern Brazil: a spatial approach.

    abstract:INTRODUCTION:The present study aimed to assess the seroprevalence and spatial distribution of Neospora caninum and Toxoplasma gondii in dogs. METHODS:Blood samples (n = 241) were collected and analyzed for the presence of anti-N. caninum and anti-T. gondii antibodies. The spatial distribution was evaluated using kerne...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/0037-8682-0440-2018

    authors: Souza IB,Fernandes PR,Silva TRM,Santos CVB,Silva NMMD,Ubirajara Filho CRC,Carvalho GA,Alves LC,Mota RA,Ramos RAN

    更新日期:2019-04-11 00:00:00

  • Evaluation of an immunochromatography test for malaria diagnosis under different storage conditions.

    abstract::This study aimed to evaluate the second-generation OptiMal test for malaria diagnosis under various storage conditions. It detected all the positive samples, except for two Plasmodium malariae samples. Further research evaluating diverse environmental conditions are important for ICT test applicability in Brazilian ma...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822005000200015

    authors: Penhalbel Rde S,Fugikaha E,Lorenzetti A,Alves RT,Cavasini CE,Rossit AR,Calvosa VS,Couto AA,Machado RL

    更新日期:2005-03-01 00:00:00

  • Coronavirus disease and basic sanitation: too early to be worried?

    abstract:INTRODUCTION:Considering that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in feces, this study aimed to verify a possible relationship between basic sanitation indices and coronavirus disease (COVID-19) numbers/rates. METHODS:Data of COVID-19 cases registered in Brazil until May 28, ...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/0037-8682-0345-2020

    authors: Silva RRD,Santos MBD,Santos ADD,Tavares DDS,Santos PLD

    更新日期:2020-01-01 00:00:00

  • Family occurrence of schistosomal hepatosplenomegaly and maternal effect.

    abstract::In this paper we present a study of members of 265 nuclear families, aged six or more. This study is based of family heredograms, and takes into account the clinical form of schistosomiasis observed before treatment with oxamniquine. The probability of occurrence of two or more cases of hepatosplenomegaly is low, notw...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86821989000100003

    authors: Tavares-Neto J,Prata A

    更新日期:1989-01-01 00:00:00

  • American cutaneous leishmaniasis triggered by electrocoagulation.

    abstract::Cutaneous leishmaniasis is usually transmitted by infected phlebotomine sand fly bites that initiate local cutaneous lesions. Few reports in the literature describe other modes of transmission. We report a case of a previously healthy 59-year-old woman who underwent electrocoagulation to remove seborrheic keratosis co...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type:

    doi:10.1590/0037-8682-0306-2017

    authors: Martins SS,Santos AO,Lima BD,Gomes CM,Sampaio RNR

    更新日期:2018-01-01 00:00:00

  • Molecular identification of the agent of Q fever - Coxiella burnetii - in domestic animals in State of Rio de Janeiro, Brazil.

    abstract:INTRODUCTION:Over the last recent years, the number of Q fever cases have has increased throughout the world. An epidemiological investigation was performed in the area in which the first molecular documentation of Q fever in Brazil was previously reported. METHODS:Indirect immunofluorescence assay (IFA) and PCR of Co...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/0037-8682-0076-2013

    authors: Mares-Guia MA,Rozental T,Guterres A,Gomes R,Almeida DN,Moreira NS,Barreira JD,Favacho AR,Santana AL,Lemos ER

    更新日期:2014-03-01 00:00:00

  • Health work in the context of a pandemic: For a research agenda.

    abstract:INTRODUCTION:The emergence of a pandemic highlights the translational demands regarding science. This communication aims to propose theoretical-methodological elements for research on health work in pandemic context. METHODS:This reflective essay sets an framework for a research project on health work in Manaus, Amazo...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/0037-8682-0427-2020

    authors: Ramos FRS,Lacerda MVG,Ferreira DS,Lima KJV,Tavares IC,Monteiro WF,Martins CMG,Silva GLATD,Andrade LLC,Monteiro WM

    更新日期:2020-11-06 00:00:00

  • [Competition between Aedes aegypti and Aedes albopictus larvae in the laboratory].

    abstract::This study had the aim of evaluating the effects of intra and interspecies larval competition between Aedes aegypti and Aedes albopictus, survival of larvae time taken to develop and wing length. The experiment was carried out with three densities and five proportions of the species. Aedes aegypti survival was greater...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822008000500009

    authors: Serpa LL,Kakitani I,Voltolini JC

    更新日期:2008-09-01 00:00:00

  • Use of a condom in sex relations by HIV carriers.

    abstract::The frequency with which condoms are used in sex relations by subjects with HIV was determined by interviewing 132 individuals, 82 men and 50 women, most of them from São Paulo state and some from other regions of the country, all of them seen at an outpatient clinic of the School of Medicine in Botucatu. The women we...

    journal_title:Revista da Sociedade Brasileira de Medicina Tropical

    pub_type: 杂志文章

    doi:10.1590/s0037-86822001000200005

    authors: Galvão MT,Marcondes-Machado J

    更新日期:2001-03-01 00:00:00