Family occurrence of schistosomal hepatosplenomegaly and maternal effect.

Abstract:

:In this paper we present a study of members of 265 nuclear families, aged six or more. This study is based of family heredograms, and takes into account the clinical form of schistosomiasis observed before treatment with oxamniquine. The probability of occurrence of two or more cases of hepatosplenomegaly is low, notwithstanding the fact that it was observed in 38 families. Even less frequent is the occurrence of three or more cases observed in 17 families (P = 0.002). The concentration of the hepatosplenic form was higher among siblings than it was among mothers and children, or fathers and children. It was found to be not significant between husband (father) and wife (mother). These observations reinforce the evidence for the presence of a genetic component in susceptibility to the hepatosplenic form of the disease. In cases in which the mother was hepatosplenic there was a higher incidence of hepatosplenic children; the relative risk was a least five times higher than in those in which the father was the affected member (the maternal effect). In cases where both members were affected by the hepatointestinal form, the risk to the filial generation was similar to that of the population in general. Thus, in the process towards severe forms of schistosomiasis mansoni, pre and post natal factors might be involved.

journal_name

Rev Soc Bras Med Trop

authors

Tavares-Neto J,Prata A

doi

10.1590/s0037-86821989000100003

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

13-8

issue

1

eissn

0037-8682

issn

1678-9849

journal_volume

22

pub_type

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