Treatment and education reduce the severity of schistosomiasis periportal fibrosis.

Abstract:

INTRODUCTION:This study evaluates the factors associated with the development of severe periportal fibrosis in patients with Schistosoma mansoni. METHODS:A cross-sectional study was conducted from April to December 2012 involving 178 patients infected with S. mansoni who were treated in the Hospital das Clínicas of Pernambuco, Brazil. Information regarding risk factors was obtained using a questionnaire. Based on the patients' epidemiological history, clinical examination, and upper abdomen ultrasound evaluation, patients were divided into 2 groups: 137 with evidence of severe periportal fibrosis and 41 patients without fibrosis or with mild or moderate periportal fibrosis. Univariate and multivariate analyses were conducted using EpiInfo software version 3.5.5. RESULTS:Illiterate individuals (30.1%) and patients who had more frequent contact with contaminated water in towns in the Zona da Mata of Pernambuco (33.2%) were at greater risk for severe periportal fibrosis. Based on multivariate analysis, it was determined that an education level of up to 11 years of study and specific prior treatment for schistosomiasis were preventive factors for severe periportal fibrosis. CONCLUSIONS:The prevailing sites of the severe forms of periportal fibrosis are still within the Zona da Mata of Pernambuco, although there has been an expansion to urban areas and the state coast. Specific treatment and an increased level of education were identified as protective factors, indicating the need for implementing social, sanitary, and health education interventions aimed at schistosomiasis to combat the risk factors for this major public health problem.

journal_name

Rev Soc Bras Med Trop

authors

Silva PC,Leal TV,Domingues AL

doi

10.1590/0037-8682-0110-2013

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

472-7

issue

4

eissn

0037-8682

issn

1678-9849

pii

S0037-86822013000400472

journal_volume

46

pub_type

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