Vaccination of C57BL/10 mice against cutaneous Leishmaniasis using killed promastigotes of different strains and species of Leishmania.

Abstract:

:Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin(R) and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences were detected between the vaccinated groups. It can be concluded that vaccines composed of single Leishmania stocks can provide protection to C57BL/10 mice against L. (L.) amazonensis infection.

journal_name

Rev Soc Bras Med Trop

authors

Mayrink W,Santos GC,Toledo Vde P,Guimaraes TM,Machado-Coelho GL,Genaro O,da Costa CA

doi

10.1590/s0037-86822002000200001

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

125-32

issue

2

eissn

0037-8682

issn

1678-9849

pii

S0037-86822002000200001

journal_volume

35

pub_type

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