[Physico-chemical characteristics of meglumine antimoniate in different storage conditions].

Abstract:

:During the period October 1992 to July 1995 we measured the osmolarity and pH of ampoules of meglumine antimoniate (glucantime) from lot 9206L-004 (manufactured by Rhodia Farma Ltd, of São Paulo, SP, Brazil) maintained in three temperature conditions namely 4 degrees C, 37 degrees C and ambiental. Although we observed statistically significant differences in osmolarity between samples, the limited number of measurements and the variation of this property in ampoules maintained at the same temperature were obstacles to obtain definitive conclusions. Such a variation was not found with pH. Assuming these parameters could reflect structural changes in the pentavalent antimony molecule, clearly further better controlled experiments are indicated.

journal_name

Rev Soc Bras Med Trop

authors

Romero GA,de Oliveira MR,Correia D,Marsden PD

doi

10.1590/s0037-86821996000500009

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

461-5

issue

5

eissn

0037-8682

issn

1678-9849

journal_volume

29

pub_type

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  • Occurrence of positivity for Trypanosoma cruzi in triatomine from municipalities in Southeastern Brazil, from 2002 to 2004.

    abstract:INTRODUCTION:from an epidemiological point of view, more than 120 species of triatomine (Hemiptera, Reduviidae) are known. The occurrence and positivity for Trypanosoma cruzi in triatomines in 16 municipalities of the Triângulo Mineiro and Alto Paranaíba were evaluated from January 2002 to December 2004. METHODS:the t...

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