Abstract:
INTRODUCTION:This study confirmed the absence of natural infection with Xenotropic murine leukemia virus-related virus (XMRV) or XMRV-related disease in human populations of the Brazilian Amazon basin. We demonstrated that 803 individuals of both sexes, who were residents of Belem in the Brazilian State of Pará, were not infected with XMRV. METHODS:Individuals were divided into 4 subgroups: healthy individuals, individuals infected with human immunodeficiency virus, type 1 (HIV-1), individuals infected with human T-lymphotrophic virus, types 1 or 2 (HTLV-1/2), and individuals with prostate cancer. XMRV infection was investigated by nested PCR to detect the viral gag gene and by quantitative PCR to detect pol. RESULTS:There was no amplification of either gag or pol segments from XRMV in any of the samples examined. CONCLUSIONS:This study supports the conclusions of the studies that eventually led to the retraction of the original study reporting the association between XMRV and human diseases.
journal_name
Rev Soc Bras Med Tropjournal_title
Revista da Sociedade Brasileira de Medicina Tropicalauthors
Gomes ST,Imbiriba L,Burbano RR,Silva AL,Feitosa RN,Cayres-Vallinoto IM,Ishak Mde O,Ishak R,Vallinoto ACdoi
10.1590/0037-8682-0075-2014subject
Has Abstractpub_date
2014-05-01 00:00:00pages
302-6issue
3eissn
0037-8682issn
1678-9849pii
S0037-86822014000300302journal_volume
47pub_type
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