First case report of cryptococcosis due to Cryptococcus decagattii in a pediatric patient in Argentina.

Abstract:

:We report the first case of cryptococcosis due to Cryptococcus decagattii in an immunocompetent pediatric patient from an indigenous community in Argentina with a successful outcome. Two isolates (blood, cerebrospinal fluid) were genotyped by restriction fragment length polymorphism of the orotidine monophosphate pyrophosphorylase (URA5) gene as VGIV and identified by multi-locus sequence typing as C. decagattii. Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification indicated genotype VGIII. The minimum inhibitory concentration of amphotericin B, fluconazole, itraconazole, and voriconazole was determined (cerebrospinal fluid: 0.25, 16, 0.12, and 0.12, blood: 0.25, 4, 0.12, and 0.06, respectively, all in mg/L).

journal_name

Rev Soc Bras Med Trop

authors

Berejnoi A,Taverna CG,Mazza M,Vivot M,Isla G,Córdoba S,Davel G

doi

10.1590/0037-8682-0419-2018

subject

Has Abstract

pub_date

2019-03-28 00:00:00

pages

e20180419

eissn

0037-8682

issn

1678-9849

pii

S0037-86822019000100706

journal_volume

52

pub_type

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