Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C.

Abstract:

INTRODUCTION:Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C. METHODS:Patients (159) with chronic hepatitis C of both genders were analyzed. RESULTS:Women showed association between HPA-3 polymorphisms and RM. CONCLUSIONS:An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.

journal_name

Rev Soc Bras Med Trop

authors

Medolago NB,Ferrasi AC,Rocha OMD,Pardini MIMC,Grotto RMT,Galvani AF,Silva GF

doi

10.1590/0037-8682-0210-2019

subject

Has Abstract

pub_date

2020-01-27 00:00:00

pages

e20190210

eissn

0037-8682

issn

1678-9849

pii

S0037-86822020000100623

journal_volume

53

pub_type

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