Abstract:
INTRODUCTION:Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes interferon-γ (IFN-γ) expression. However, the role it exerts on regulatory B cells (CD19+CD24hiCD38hi; Breg) is unknown. METHODS:The frequencies of Treg and Breg cells was evaluated and the Th1 profiles were assessed in TSP/HAM patients and healthy control subjects. RESULTS:Low percentages of Breg cells and high production of IFN-γ were observed in patients compared to those in healthy control subjects. CONCLUSIONS:The low percentage of Breg cells in patients and the increase in the frequency of Th1 cells suggest an imbalance in the control of the inflammatory response that contributes to the immunopathogenesis of TSP/HAM.
journal_name
Rev Soc Bras Med Tropjournal_title
Revista da Sociedade Brasileira de Medicina Tropicalauthors
Burbano YCB,Paz AVC,Caldon CCR,Constain JSR,Gonzáles GIÁ,Hernández JCK,Marin-Agudelo N,Dueñas-Cuellar RA,Castaño VENdoi
10.1590/0037-8682-0101-2019subject
Has Abstractpub_date
2019-07-18 00:00:00pages
e20190101eissn
0037-8682issn
1678-9849pii
S0037-86822019000100325journal_volume
52pub_type
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