Immunotherapy, immunochemotherapy and chemotherapy for American cutaneous leishmaniasis treatment.

Abstract:

:The first choice of treatment for American cutaneous leishmaniasis is the pentavalent antimonial drug. Although it has been shown that this treatment is mostly effective and indicated, some disadvantages should be taken into account such as side effects, long term treatment inconveniences and counter-indication for patients suffering from cardiopathy, nephropathy; yet, aging, pregnancy and other conditions. With the advent of the vaccine anti-American cutaneous leishmaniasis as a prophylactic measure, studies on therapy using the vaccine associated or not with other drugs have been performed by many investigators and it is currently among the alternative treatments and prevention measures for American cutaneous leishmaniasis. In conclusion, the association between antimony and vaccine (immunochemotherapy) showed the same cure rate when compared with the standard treatment (100%) and it was also able to reduce the salt volume in 17.9% and treatment length from 87 to 62 days, decreasing side effects.

journal_name

Rev Soc Bras Med Trop

authors

Mayrink W,Botelho AC,Magalhães PA,Batista SM,Lima Ade O,Genaro O,Costa CA,Melo MN,Michalick MS,Williams P,Dias M,Caiaffa WT,Nascimento Ed,Machado-Coelho GL

doi

10.1590/s0037-86822006000100003

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

14-21

issue

1

eissn

0037-8682

issn

1678-9849

pii

S0037-86822006000100003

journal_volume

39

pub_type

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