Longitudinal study of the indirect immunofluorescence and complement fixation tests for diagnosis of Chagas' disease in immunosuppressed patients submitted to renal transplantation.

Abstract:

:Clinical and serological follow-up of 7 patients submitted to renal transplantation and presenting positive serological reactions to Chagas' disease before immunosuppression did not show significant changes in indirect immunofluorescence and complement fixation titres for Chagas' disease, or signs and symptoms indicating exacerbation of the disease during follow-up. In addition, 18 of 66 recipients of renal transplants considered to be non-chagasic before immunosuppression showed at least one positive result to the indirect immunofluorescence test for Chagas' disease during the study period. The results suggest that the immunosuppression state induced in chagasic patients submitted to renal transplant did not promoted exacerbation of the chronic infection in these patients and not interfere with the serological response of chronic chagasics, thus permitting the use of these serologic reactions for diagnostic purposes in these cases. However, the positive results of the indirect immunofluorescence test in non-chagasic patients indicate the need for judicious interpretation of the indirect immunofluorescence test for the diagnosis of Chagas' disease in renal transplanted patients.

journal_name

Rev Soc Bras Med Trop

authors

Figueiredo JF,Fiorillo AM,Ferraz AS

doi

10.1590/s0037-86821993000400002

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

211-4

issue

4

eissn

0037-8682

issn

1678-9849

journal_volume

26

pub_type

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