Abstract:
INTRODUCTION:Based on reports, infection with Mycobacterium tuberculosis is believed to induce the development of antibodies that are considered to be biological indicators for the diagnosis of some other diseases. However, conflicting results have been published regarding the presence of antineutrophil cytoplasmic antibodies (ANCAs) in patients with tuberculosis. We aim to study the seroprevalence of ANCA in a population of Chinese patients with tuberculosis, which may lead to the misdiagnosis of vasculitic disorders. METHODS:The study was conducted from January 2016 to May 2017 to evaluate the presence of ANCA in 103 Chinese patients using indirect immunofluorescent assay. An enzyme-linked immunosorbent assay was performed for anti-myeloperoxidase (MPO) and anti-proteinase 3 (PR3) detection. RESULTS:Perinuclear ANCA (p-ANCA) was detected in 4.8% (5/103) of patients, whereas cytoplasmic ANCA (c-ANCA) was not detected; 1.9% (2/103) of patients with tuberculosis was positive for anti-MPO antibodies, and none had anti-PR3 antibodies. Both anti-MPO-positive patients were diagnosed with ANCA-associated vasculitides. CONCLUSIONS:ANCA positivity may be more related to vasculitis and immunological disorders than to a M. tuberculosis infection. Therefore, to improve diagnostic accuracy, patients with M. tuberculosis who are ANCA positive should be investigated for concurrent diseases, including the effects of drugs. Therefore, even in tuberculosis epidemic area, ANCA seropositivity, detected by ELISA, is still more suggestive of ANCA-associated vasculitides.
journal_name
Rev Soc Bras Med Tropjournal_title
Revista da Sociedade Brasileira de Medicina Tropicalauthors
Huan G,Yang G,Xiao-Yu Q,Jiancheng X,Yan-Qing Sdoi
10.1590/0037-8682-0400-2017subject
Has Abstractpub_date
2018-07-01 00:00:00pages
475-478issue
4eissn
0037-8682issn
1678-9849pii
S0037-86822018000400475journal_volume
51pub_type
杂志文章abstract:INTRODUCTION:Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying assoc...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0210-2019
更新日期:2020-01-27 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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doi:10.1590/s0037-86822011000100024
更新日期:2011-01-01 00:00:00
abstract::In order to assess the reliability of the thick smear in a Plasmodium infection area, 322 thick smears were examined by a trained microscopist in field conditions. Later, the same smears were examined by an experience microscopist in ideal laboratory conditions. Reliability was measured by the Kappa index. In symptoma...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,评审
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更新日期:1998-03-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
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pub_type:
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,评审
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:
更新日期:1999-11-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821992000300005
更新日期:1992-07-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821994000300001
更新日期:1994-07-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822006000500004
更新日期:2006-09-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type:
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更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Illicit drug users (DUs) are vulnerable to hepatitis C virus (HCV) infection. The shared use of illicit drugs is the main method of HCV transmission. METHODS:A cross-sectional study was conducted in Breves, in northern Brazil. We surveyed 187 DUs to determine the prevalence of and factors associated with ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00