Abstract:
INTRODUCTION:Hepatitis B virus (HBV) constitutes an important risk factor for cirrhosis and hepatocellular carcinoma (HCC). The link between circulating microRNAs and HBV has been previously reported, although not as a marker of liver disease progression in chronic hepatitis B (CHB). The aim of this study was to characterize miRNA expression profiles between CHB with and without cirrhosis or HCC. METHODS: :A total of 12 subjects were recruited in this study. We employed an Affymetrix Gene Chip miRNA 3.0 Array to provide universal miRNA coverage. We compared microRNA expression profiles between CHB with and without cirrhosis/HCC to discover possible prognostic markers associated with the progression of CHB. RESULTS: :Our results indicated 8 differently expressed microRNAs, of which miRNA-935, miRNA-342, miRNA-339, miRNA-4508, miRNA-3615, and miRNA-3200 were up-regulated, whereas miRNA-182 and miRNA-4485 were down-regulated in patients with CHB who progressed to cirrhosis/HCC as compared to those without progression. CONCLUSIONS: :We demonstrated the differential expression of miRNA-935, miRNA-342, miRNA-339, miRNA-4508, miRNA-3615, miRNA-3200, miRNA-182, and miRNA-4485 between patients with HBV without cirrhosis/HCC and those who had progressed to these more severe conditions. These miRNAs may serve as novel and non-invasive prognostic markers for early detection of CHB-infected patients who are at risk of progression to cirrhosis and/or HCC.
journal_name
Rev Soc Bras Med Tropjournal_title
Revista da Sociedade Brasileira de Medicina Tropicalauthors
Riazalhosseini B,Mohamed R,Apalasamy YD,Langmia IM,Mohamed Zdoi
10.1590/0037-8682-0416-2016subject
Has Abstractpub_date
2017-03-01 00:00:00pages
161-166issue
2eissn
0037-8682issn
1678-9849pii
S0037-86822017000200161journal_volume
50pub_type
杂志文章abstract::During the period from 1994 to 1999 cutaneous leishmaniasis was reported in 32 (89%) out of 36 municipalities in the Metropolitan Region of Belo Horizonte, Brazil, of which one (2,8%) municipality was classified as a very high risk area, 16 (44,5%) as high risk, seven (19,4%) as moderate risk areas and 12 (33,3%) as l...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract:INTRODUCTION:An epidemiological study was undertaken to identify determinant factors in the occurrence of American cutaneous leishmaniasis in areas under the influence of hydroelectric plants in Paranapanema river, State of Paraná, Brazil. The ecological aspects of the phlebotomine fauna were investigated. METHODS:San...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822012000400003
更新日期:2012-07-01 00:00:00
abstract::From a canine case of american cutaneous leishmaniasis in the locality of Santa Rita de Cássia, municipality of Barra Mansa, Rio de Janeiro, a serological survey was performed on 177 dogs and 43 cats. Evaluation of the canine serum samples showed that 10% had a positive reaction in the indirect immunofluorescence test...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822009000200009
更新日期:2009-03-01 00:00:00
abstract:INTRODUCTION:Exclusive or associated lesions in various structures of the autonomic nervous system occur in the chronic forms of Chagas disease. In the indeterminate form, the lesions are absent or mild, whereas in the exclusive or combined heart and digestive disease forms, they are often more pronounced. Depending on...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,评审
doi:10.1590/s0037-86822012000200020
更新日期:2012-03-01 00:00:00
abstract::This study had the aim of determining the coefficient of leprosy detection among the student population of the municipality of Buriticupu, State of Maranhão. An active case search method was used, covering a population of 14,653 students, in 53 schools within the municipal network. Clinical examination gave rise to a ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822007000600012
更新日期:2007-11-01 00:00:00
abstract:INTRODUCTION:The saliva of mosquitoes has an important role in the transmission of several diseases, including malaria, and contains substances with vasomodulating and immunomodulating effects to counteract the host physiological mechanisms and enhance pathogen transmission. As immunomodulatory components, salivary gla...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0185-2015
更新日期:2015-07-01 00:00:00
abstract::This is a retrospective study with ecological features that describes the epidemiological pattern and geographical distribution of American tegumentary leishmaniasis cases in Campinas, São Paulo, between 1992 and 2003. The probable infection locations were georeferenced by means of Global Position System and spatially...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822009000300013
更新日期:2009-05-01 00:00:00
abstract::with the objective of evaluating shortened therapeutic outlines effective in vivax malaria treatment, we accomplished an open, prospective study allocating 234 patients with vivax malaria distributed at random into eight therapeutic groups. Six groups used oral arthemisin as blood esquizonticide at different doses for...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2003-03-01 00:00:00
abstract:INTRODUCTION:Acquired immunodeficiency syndrome (AIDS) is being increasingly reported among the elderly and major depression (MD) may be associated with suboptimal adherence to treatment. METHODS:Cross-sectional study on factors associated with MD among 72 HIV-infected elderly individuals. RESULTS:Twenty (27.7%) pati...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-1228-2013
更新日期:2013-05-01 00:00:00
abstract::Male Indian buffalo (Bubalus bubalis) calves were submitted to Schistosoma mansoni infection by percutaneous, oral and subcutaneous routes. No worms or eggs were found in four of the animals tested. Bubalus bubalis appears to be refractory for S. mansoni. ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821989000300008
更新日期:1989-07-01 00:00:00
abstract:INTRODUCTION:This paper presents the results of an extensive survey of freshwater mollusks in the Simplício Queda Única Hydroelectric Development area, Southeast Brazil. METHODS:Mollusks were collected between 2008 and 2013. All specimens were examined for the presence of larval trematodes. RESULTS:In total, 12,507 s...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0334-2017
更新日期:2018-09-01 00:00:00
abstract:INTRODUCTION:Leptospirosis is an endemic disease in Brazil that can become an epidemic during the rainy season resulting from floods in areas susceptible to natural disasters. These areas are widespread in Santa Catarina, particularly in the coastal region. Therefore, the objective of this study was to identify environ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0466-2020
更新日期:2020-12-11 00:00:00
abstract::We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing c...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0401-2020
更新日期:2020-01-01 00:00:00
abstract::An outbreak of American Cutaneous Leishmaniasis (ACL) occurring in the Northeast region of São Paulo state in 1992 is described. After the notification of the 12 human cases, a skin test survey of the local population was carried out in a rural area of the Itupeva municipality. The survey consisted of 144 interviews a...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821995000300013
更新日期:1995-07-01 00:00:00
abstract:INTRODUCTION:Favorable responses in American tegumentary leishmaniasis (ATL) patients to treatment with 5 mg Sbv/kg/day meglumine antimoniate (MA) has been reported in Rio de Janeiro, but little is known regarding the therapeutic response to low doses in patients from other locations. METHODS:A retrospective review of...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0464-2017
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION:Rapid diagnostic tests (RDTs) are selected based on their performances. Here, we compared the diagnostic performance of different malaria RDTs. METHODS:Febrile patients were tested for malaria using Vikia Malaria Pf/Pan, Meriline-Meriscreen Pf/Pv/Pan, Right Sign Malaria Pf/Pan, and Right Sign Malaria Pf R...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0274-2019
更新日期:2020-06-22 00:00:00
abstract::Cutaneous leishmaniasis is usually transmitted by infected phlebotomine sand fly bites that initiate local cutaneous lesions. Few reports in the literature describe other modes of transmission. We report a case of a previously healthy 59-year-old woman who underwent electrocoagulation to remove seborrheic keratosis co...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type:
doi:10.1590/0037-8682-0306-2017
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:This study aimed to analyze social factors involved in the spatial distribution and under-reporting of tuberculosis (TB) in the city of Vitória, Espírito Santo State, Brazil. METHODS:This was an ecological study of the reported cases of TB between 2009 and 2011, according to census tracts. The outcome was...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0015-2018
更新日期:2018-09-01 00:00:00
abstract::This study had the aim of ascertaining epidemiological and clinical differences in envenoming caused by Bothrops spp between elderly adults (>60 years) and non-elderly adults (20 to 59 years). The data were obtained from 1,930 medical records of patients attended at the Butantan Institute between 1981 and 1992. The gr...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822008000100009
更新日期:2008-01-01 00:00:00
abstract::Vancomycin is the first-line agent for the treatment of bacteremia, endocarditis, pneumonia, cellulitis, and osteomyelitis. Pancytopenia is an uncommon adverse effect of vancomycin therapy, with only a few cases of vancomycin-related neutropenia and pancytopenia described in the literature. We describe a case of a 56-...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0263-2015
更新日期:2016-04-01 00:00:00
abstract:INTRODUCTION:This study characterized the clinico-epidemiological profile of American cutaneous leishmaniasis (ACL) cases in Barbalha, Ceará State, Brazil. METHODS:Medical records of 363 patients visiting Federal University of Cariri between 2009 and 2014 were analyzed. RESULTS:ACL was more prevalent in men with low ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0504-2017
更新日期:2018-11-01 00:00:00
abstract::Cryptococcus neoformans is an encapsulated yeast agent of human and animal cryptococcosis. The variety neoformans is an important cause of mortality in AIDS-patients throughout the world. It has already been isolated worldwide from different environmental sources, including avian habitats. However, in spite of the occ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822002000600008
更新日期:2002-11-01 00:00:00
abstract::We present a case of human intoxication due to a snakebite by the opisthoglyphous dipsadid Thamnodynastes lanei. A 26-year-old man was bitten on the right hand and was not medicated. Bleeding lasted a few seconds, while paresthesia, chills, and headache persisted for up to 10 hours. The pain disappeared after a week, ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type:
doi:10.1590/0037-8682-0194-2020
更新日期:2020-11-13 00:00:00
abstract::With the aim of evaluating the cardiac autonomic function in elderly chagasic patients living in an endemic area, we evaluated, by using computadorized heart rate variability, 28 elderly chagasic with the indeterminate form, 28 elderly non chagasic and 28 young healthy control. In all patients we performed conventiona...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract:INTRODUCTION:In Brazil, studies have shown that HTLV seroprevalence among pregnant women varies from 0 to 1.8%. However, this seroprevalence was unknown in the State of Pará, Brazil. The present study describes, for the first time, the HTLV seroprevalence among pregnant women from the State of Pará, Northern Brazil. M...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822012005000007
更新日期:2012-07-01 00:00:00
abstract::This study aimed to evaluate the second-generation OptiMal test for malaria diagnosis under various storage conditions. It detected all the positive samples, except for two Plasmodium malariae samples. Further research evaluating diverse environmental conditions are important for ICT test applicability in Brazilian ma...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822005000200015
更新日期:2005-03-01 00:00:00
abstract:INTRODUCTION::Trypanosoma cruzi is the etiologic agent of Chagas disease in humans, mainly in Latin America. Trypanosome stocks were isolated by hemoculture from patients followed at Evandro Chagas National Institute of Infectious Diseases (FIOCRUZ) and studied using different approaches. METHODS::For species and geno...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0406-2016
更新日期:2017-01-01 00:00:00
abstract::Cyclospora cayetanensis causes watery diarrhea in tropical countries, among travelers and after ingestion of contaminated water and food. Very little is known about its epidemiology, pathogenic aspects and reservoirs. In Brazil, its prevalence is unknown and to date there have been reports of three outbreaks. We repor...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822005000400009
更新日期:2005-07-01 00:00:00
abstract:INTRODUCTION:We sought to determine risk factors (RFs) associated with the presence of antibodies against Leishmania in dogs from a rural area of Ilha Solteira, SP, Brazil. METHODS:Serum samples were collected from 250 dogs and tested using indirect enzyme-linked immunosorbent assay (ELISA) and indirect immunofluoresc...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0059-2020
更新日期:2020-09-11 00:00:00
abstract::Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnos...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,实务指引
doi:10.1590/0037-8682-0230-2017
更新日期:2017-09-01 00:00:00