Brazilian guidelines for the clinical management of paracoccidioidomycosis.

Abstract:

:Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis ( P. brasiliensis ) complex has been known to be the causal agent of paracoccidiodomycosis, a new species, Paracoccidioides lutzii ( P. lutzii ), has been reported in Rondônia, where the disease has reached epidemic levels, and in the Central West and Pará. Accurate diagnoses and availability of antigens that are reactive with the patients' sera remain significant challenges. Therefore, the present guidelines aims to update the first Brazilian consensus on paracoccidioidomycosis by providing evidence-based recommendations for bedside patient management. This consensus summarizes etiological, ecoepidemiological, molecular epidemiological, and immunopathological data, with emphasis on clinical, microbiological, and serological diagnosis and management of clinical forms and sequelae, as well as in patients with comorbidities and immunosuppression. The consensus also includes discussion of outpatient treatments, severe disease forms, disease prevalence among special populations and resource-poor settings, a brief review of prevention and control measures, current challenges and recommendations.

journal_name

Rev Soc Bras Med Trop

authors

Shikanai-Yasuda MA,Mendes RP,Colombo AL,Queiroz-Telles F,Kono ASG,Paniago AMM,Nathan A,Valle ACFD,Bagagli E,Benard G,Ferreira MS,Teixeira MM,Silva-Vergara ML,Pereira RM,Cavalcante RS,Hahn R,Durlacher RR,Khoury Z,Camar

doi

10.1590/0037-8682-0230-2017

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

715-740

issue

5

eissn

0037-8682

issn

1678-9849

pii

S0037-86822017005001101

journal_volume

50

pub_type

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