Abstract:
INTRODUCTION:Favorable responses in American tegumentary leishmaniasis (ATL) patients to treatment with 5 mg Sbv/kg/day meglumine antimoniate (MA) has been reported in Rio de Janeiro, but little is known regarding the therapeutic response to low doses in patients from other locations. METHODS:A retrospective review of medical records was conducted to compare the therapeutic response to 5 mg Sbv/kg/day MA treatment among 36 patients who acquired ATL in Brazilian states other than Rio de Janeiro (OS group) and 72 patients from Rio de Janeiro (RJ group). RESULTS:One course of 5 mg Sbv/kg/day MA cured 72.8% of 81 cutaneous (CL) and 66.6% of 27 mucosal (ML) leishmaniasis-infected patients: 70% in the CL/RJ group, 81% in the CL/OS group, 50% in the ML/RJ group, and 80% in the ML/OS group. After up to two additional treatment courses at the same dose, 88.9% and 85.2% of the CL and ML patients were cured, respectively. Adverse events were observed in 40% of patients in the CL/RJ group, 57% of the CL/OS group, 58% of the ML/RJ group, and 80% of the ML/OS group. No significant differences were observed in the cure rates or adverse effects between the RJ and OS groups. No patients required permanent discontinuation of treatment due to adverse events. CONCLUSIONS:Patients with ATL acquired in both RJ and OS may respond to low-dose MA. While high-dose MA should remain the standard treatment for ATL, low-dose MA might be preferred when toxicity is a primary concern.
journal_name
Rev Soc Bras Med Tropjournal_title
Revista da Sociedade Brasileira de Medicina Tropicalauthors
Cataldo JI,Conceição-Silva F,Antônio LF,Schubach AO,Marzochi MCA,Valete-Rosalino CM,Pimentel MIF,Lyra MR,Oliveira RVC,Barros JHDS,Pacheco RDS,Madeira MFdoi
10.1590/0037-8682-0464-2017subject
Has Abstractpub_date
2018-11-01 00:00:00pages
769-780issue
6eissn
0037-8682issn
1678-9849pii
S0037-86822018000600769journal_volume
51pub_type
杂志文章abstract:INTRODUCTION:Currently, dengue fever, chikungunya fever, and zika virus represent serious public health issues in Brazil, despite efforts to control the vector, the Aedes aegypti mosquito. METHODS: :This was a descriptive and ecological study of dengue deaths occurring from 2002 to 2013 in São Luis, Maranhão, Brazil. ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0272-2016
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The genus Staphylococcus is of great importance because of its high prevalence in hospital infections and because it presents high rates of resistance to oxacillin and other antimicrobials. Thus, evaluation of the accuracy of the phenotypic methods that are used to determine the profile of antimicrobial re...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822010000300017
更新日期:2010-05-01 00:00:00
abstract::Benznidazole, drug of choice for Chagas disease (CD), has been associated with a high incidence of adverse reactions that can become serious, necessitating discontinuation of the drug. We describe the case of a Bolivian patient living in Spain for 9 years, who, following treatment with benznidazole for CD in indetermi...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type:
doi:10.1590/0037-8682-0071-2016
更新日期:2017-01-01 00:00:00
abstract::This study aimed to describe the epidemiology and spread of visceral leishmaniasis in the municipality of Várzea Grande, State of Mato Grosso, Brazil, between 1998 and 2007. Forty-eight human cases were reported, with an incidence rate of up to 11.7 per 100,000 inhabitants, particularly among children and adolescents ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822009000500005
更新日期:2009-09-01 00:00:00
abstract::Mansonic schistosomiasis remains a medical-social issue in Northeastern Brazil. In children, surgical treatment includes splenectomy and spleen autoimplantation. This procedure reduces post-splenectomy sepsis. The aim of this study was to analyze the phagocyte rate and the cellular viability of monocytes in patients w...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822006000500004
更新日期:2006-09-01 00:00:00
abstract::The objectives of this study were to investigate the frequency of pityriasis versicolor occurrence and to identify yeasts of the genus Malassezia in patients at the mycology laboratory of the Federal University of Goiás, in Goiânia, State of Goiás. Ninety-five cases of pityriasis versicolor were diagnosed, and four sp...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822006000600017
更新日期:2006-11-01 00:00:00
abstract:INTRODUCTION:We report the larvicidal activity of two formulations from Amanita muscariaagainst Culex quinquefasciatus, as well as the viability of the aqueous extract after storage. METHODS The larvicidal activity of aqueous extract and powder from A. muscaria, and the viability of the aqueous extract after storage, w...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0175-2015
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Tropical spastic paraparesis/HTLV-1 associated myelopathy (TSP/HAM) is a disease caused by human T-cell lymphotropic virus type 1 (HTLV-I) that mainly infects CD4 T cells-for example, those of the CD4+CD25hiFOXP3+ [Treg] phenotype-where it inhibits forkhead box protein P3 (FOXP3) expression and promotes in...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0101-2019
更新日期:2019-07-18 00:00:00
abstract:INTRODUCTION:Previous studies have shown high residual risk of transfusing a blood donation contaminated by human immunodeficiency virus (HIV) or hepatitis C virus (HCV) in Brazil and motivated the development of a Brazilian platform for simultaneous detection of both viruses by nucleic acid amplification test (NAT) de...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0133-2014
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:This study evaluates the factors associated with the development of severe periportal fibrosis in patients with Schistosoma mansoni. METHODS:A cross-sectional study was conducted from April to December 2012 involving 178 patients infected with S. mansoni who were treated in the Hospital das Clínicas of Pe...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0110-2013
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:This study aimed to confirm the identification of Enterococcus gallinarum and Enterococcus casseliflavus isolated from clinical and food samples by PCR-RFLP. METHODS:Fifty-two strains identified by conventional biochemical exams were submitted to PCR amplification and digested with HinfI. Only 20 (38.5%) ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822010000100023
更新日期:2010-01-01 00:00:00
abstract::Eight hundred and sixty six bio-sensors for the passive detection of triatomine bugs, were tried in intra-domiciles of thirteen municipalities of an endemic area of Triatoma sordida in the North of Minas Gerais State, Brazil. This species is nowadays the most captured in Brazil and mainly in the above region. The sens...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822005000500002
更新日期:2005-09-01 00:00:00
abstract::Recurrent cutaneous or mucosal candidiasis is characterized by the occurrence of at least four candidiasis episodes within a one-year period. The factors involved in recurrence of infection are still unknown. In the present study the lymphoproliferative response and the IFN-gamma production by candidiasis patients wer...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822003000500005
更新日期:2003-09-01 00:00:00
abstract::Chronic chagasic cardiomyopathy remains a major cause of death due to heart failure in Latin American countries and for which there is currently no effective treatment. While chagasic patients wait for the development of more efficient and less toxic chemotherapeutics for the elimination of Trypanosoma cruzi, a new st...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,评审
doi:10.1590/s0037-86822004000600012
更新日期:2004-11-01 00:00:00
abstract::The distribution of the most frequent enteroparasites in the population of Assis, State of São Paulo, was studied from 1990 to 1992. A total of 18,366 medical examinations from six sanitary care centers in the neighbourhoods of Marialves, Progresso, city center, Xavier, Fiúza and Bonfim were analyzed. The general prev...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821999000500013
更新日期:1999-09-01 00:00:00
abstract::The author presents his personal point of view on the present situation of Chagas' disease control in Latin America countries. He compares the situation with African trypanosomiasis. He comments on the existence of cases in other Continents. He emphasizes the success of the fighting against domiciliated triatomine bug...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章,评审
doi:10.1590/s0037-86821997000600014
更新日期:1997-11-01 00:00:00
abstract::This is the first published case report of an 11-year-old patient with a rupture of a liver hydatid cyst (HC) into the peritoneal cavity after an abdominal trauma in Iran. The disease was diagnosed using focused abdominal sonography for trauma. To date, no cases of traumatic ruptures of liver HCs in children have been...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type:
doi:10.1590/0037-8682-0292-2017
更新日期:2017-11-01 00:00:00
abstract::From 1954 to 1990 granuloma inguinale was diagnosed in 259 patients al the dermatology service of the Universidade Federal do Pará in Belém, Brazil. Among them, 56 cases had occurred in the twenty-year period 1954-1974 and as many as 133 cases were seen during the last five years only. Greater sexual liberty, poor soc...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821991000400008
更新日期:1991-10-01 00:00:00
abstract::With the aim of evaluating the cardiac autonomic function in elderly chagasic patients living in an endemic area, we evaluated, by using computadorized heart rate variability, 28 elderly chagasic with the indeterminate form, 28 elderly non chagasic and 28 young healthy control. In all patients we performed conventiona...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract:INTRODUCTION:IgG subclasses involved in the immune response to hepatitis C virus (HCV) antigens have been rarely studied. We investigated the immune response mediated by IgG1 and IgG4 antibodies against the recombinant core and NS3 antigens in patients with chronic hepatitis C. METHODS:Sixty patients infected with HCV...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0491-2018
更新日期:2019-03-07 00:00:00
abstract:INTRODUCTION:Amphotericin B, azole or sulfamide drugs are used for treatment of patients with paracoccidioidomycosis. Among the azole drugs, voriconazole was active in vitro against Paracoccidioides brasiliensis and showed efficacy in the treatment of patients infected with this fungus.In the present study the antifung...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::This work describes radiography studies of the esophagus in chagasic patients of the Mambaí project over a 25 year period. Each person realized two radiographs in four different periods (1975-1976, 1980-1982, 1988-1991 and 1998-2000). The first radiograph was realized in the right anterior oblique position after swall...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822006000200003
更新日期:2006-03-01 00:00:00
abstract:INTRODUCTION:Besides mosquito species adapted to urban environments (Culex quinquefasciatus, Aedes aegypti and Aedes albopictus), only 15 species of Anopheles had been recorded in the State of Pernambuco. METHODS:Human-landing mosquitoes were collected in Dois Irmãos Park, in Recife. RESULTS:The first report for the ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822010000400024
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:Hantavirus cardiopulmonary syndrome (HCPS) is rare in Northeastern Brazil. METHODS:Prospective surveillance was conducted over a two-year period in Alagoas State, Northeastern Brazil. The prevalence of anti-hantavirus N-antigen IgM and IgG in human serum samples was determined by enzyme-linked immunosorbe...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0117-2017
更新日期:2017-11-01 00:00:00
abstract::The type of pulmonary histoplasmosis presents limited lesions to the lungs, with symptoms that are clinically and radiological similar to chronic pulmonary tuberculosis. This paper describes the clinical features of four cases of pulmonary histoplasmosis. Aspects of diagnostic and clinical, epidemiological, laboratory...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86822010000500028
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Monitoring disability trends is required to evaluate leprosy elimination. We assessed the trends in disability indicators and its association with space in Alagoas, Brazil. METHODS:We conducted an ecological study in all leprosy cases from 2006 to 2016. Disability indicators were analyzed using the joinpo...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-0540-2018
更新日期:2019-07-18 00:00:00
abstract::In a randomised double-blind study 122 volunteers living in an endemic malarious area in Amazonian Rondônia state were divided into 4 groups to study malaria suppression. . The first group received 500 mg of mefloquine every month, group II 250 mg every two weeks, group III a tablet of Fansidar (500 mg sulphadoxine + ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1590/s0037-86821993000300005
更新日期:1993-07-01 00:00:00
abstract::The authors present schistosomiasis mortality data in the country, in macrozones and in the federal units during the period of 1977-86. They relate mortality average to the control program. Its impact seems to be evident, especially concerning the population that underwent treatment. Here the reinfection risk has been...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821990000300001
更新日期:1990-07-01 00:00:00
abstract::An epidemiological survey was carried out in 3,344 people of an urban town in Lagamar, Minas Gerais, Brazil--during 1992-1993, to evaluate the main risk factors related to taeniasis and cysticercosis. A total number of 875 (78.9%) houses were visited and 1080 (32.3%) subjects were clinically examined. Poor sanitary co...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821998000100009
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Professionals who handle rodents in the field and in the laboratory are at risk of infection by the microorganis mharbored by these animals. METHODS:Serum samples from professionals involved in rodent and Yersinia pestis handling in field or laboratory work were analyzed to determine hantavirus and plague...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/0037-8682-1394-2013
更新日期:2013-07-01 00:00:00