[Evaluation of the performance of immunological parameters as indicators for clinical progression of chronic HTLV-1 infection].

Abstract:

:This study evaluated the performance of single and combined laboratory parameters, B-lymphocyte percentages (%LB), T/B cell ratio and %CD8+HLA-DR+/CD8+, to differentiate asymptomatic cases (AS) from HAM/TSP patients (HT) within a population of HTLV-1 seropositive cases. Percentage indices demonstrated that each parameter alone presented moderate performance, with co-negativity of 83 and 91% for %LB and T/B cell ratio, respectively, and co-positivity of 78% for %CD8+HLA-DR+/CD8+. Combined analysis (%CD8+HLA-DR+/CD8+ and T/B cell ratio) did not show any substantial performance enhancement (co-positivity = 75% and co-negativity = 74%). Likelihood ratio analysis using different value ranges for the separate parameters revealed that HTLV-1 seropositive cases with %LB<7%, T/B cell ratio>11 and %CD8+HLA-DR+/CD8+>70% would have, respectively, 11, 19 and 10 times greater chance of belonging to the HT group. Therefore, use of these phenotypic indicators as complementary laboratory methods for monitoring the clinical progression of chronic HTLV-1 infection is recommended.

journal_name

Rev Soc Bras Med Trop

authors

Coelho-dos-Reis JG,Rocha RD,Brito-Melo GE,Ribas JG,Carneiro-Proietti AB,Catalan-Soares B,Barbosa-Stancioli EF,Grupo Interdisciplinar de Pesquisas em HTLV.,Martins-Filho OA

doi

10.1590/s0037-86822007000100006

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

29-36

issue

1

eissn

0037-8682

issn

1678-9849

pii

S0037-86822007000100006

journal_volume

40

pub_type

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