Safety and Immunogenicity of Sequential Rotavirus Vaccine Schedules.

Abstract:

BACKGROUND AND OBJECTIVES:Although both licensed rotavirus vaccines are safe and effective, it is often not possible to complete the schedule by using the same vaccine formulation. The goal of this study was to investigate the noninferiority of the immune responses to the 2 licensed rotavirus vaccines when administered as a mixed schedule compared with administering a single vaccine formulation alone. METHODS:Randomized, multicenter, open-label study. Healthy infants (6-14 weeks of age) were randomized to receive rotavirus vaccines in 1 of 5 different schedules (2 using a single vaccine for all doses, and 3 using mixed schedules). The group receiving only the monovalent rotavirus vaccine received 2 doses of vaccine and the other 4 groups received 3 doses of vaccine. Serum for immunogenicity testing was obtained 1 month after the last vaccine dose and the proportion of seropositive children (rotavirus immunoglobulin A ≥20 U/mL) were compared in all the vaccine groups. RESULTS:Between March 2011 and September 2013, 1393 children were enrolled and randomized. Immune responses to all the sequential mixed vaccine schedules were shown to be noninferior when compared with the 2 single vaccine reference groups. The proportion of children seropositive to at least 1 vaccine antigen at 1 month after vaccination ranged from 77% to 96%, and was not significantly different among all the study groups. All schedules were well tolerated. CONCLUSIONS:Mixed schedules are safe and induced comparable immune responses when compared with the licensed rotavirus vaccines given alone.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Libster R,McNeal M,Walter EB,Shane AL,Winokur P,Cress G,Berry AA,Kotloff KL,Sarpong K,Turley CB,Harrison CJ,Pahud BA,Marbin J,Dunn J,El-Khorazaty J,Barrett J,Edwards KM,VTEU Rotavirus Vaccine Study Work Group.

doi

10.1542/peds.2015-2603

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

e20152603

issue

2

eissn

0031-4005

issn

1098-4275

pii

peds.2015-2603

journal_volume

137

pub_type

杂志文章,多中心研究,随机对照试验
  • Efficacy of intranasal midazolam in facilitating suturing of lacerations in preschool children in the emergency department.

    abstract::Sedating children safely and effectively for minor laceration repair is a well-recognized clinical problem. A randomized, double-blind, and controlled study was conducted to evaluate the efficacy of intranasal midazolam for reducing stress during the suturing of lacerations in preschool children. Fifty-nine children w...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Theroux MC,West DW,Corddry DH,Hyde PM,Bachrach SJ,Cronan KM,Kettrick RG

    更新日期:1993-03-01 00:00:00

  • High-deductible health plans.

    abstract::High-deductible health plans (HDHPs) are insurance policies with higher deductibles than conventional plans. The Medicare Prescription Drug Improvement and Modernization Act of 2003 linked many HDHPs with tax-advantaged spending accounts. The 2010 Patient Protection and Affordable Care Act continues to provide for HDH...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0555

    authors: Committee on Child Health Financing.

    更新日期:2014-05-01 00:00:00

  • Patent Ductus Arteriosus of the Preterm Infant.

    abstract::Postnatal ductal closure is stimulated by rising oxygen tension and withdrawal of vasodilatory mediators (prostaglandins, nitric oxide, adenosine) and by vasoconstrictors (endothelin-1, catecholamines, contractile prostanoids), ion channels, calcium flux, platelets, morphologic maturity, and a favorable genetic predis...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2020-1209

    authors: Hamrick SEG,Sallmon H,Rose AT,Porras D,Shelton EL,Reese J,Hansmann G

    更新日期:2020-11-01 00:00:00

  • Which children benefit the most from early intervention?

    abstract::Recent findings from three separate studies support and extend a large and growing body of early-intervention research literature spanning 30 years. The literature is consistent in demonstrating positive developmental outcomes as a result of intensive early intervention for children of low-income and undereducated fam...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ramey CT,Ramey SL

    更新日期:1994-12-01 00:00:00

  • Invasive pneumococcal disease in infants younger than 90 days before and after introduction of PCV7.

    abstract:BACKGROUND:Introduction of the heptavalent pneumococcal conjugate vaccine (PCV7) changed the epidemiology of invasive pneumococcal disease (IPD). We evaluated the changes that occurred after PCV7 introduction among Utah infants aged 1 to 90 days, too young to be fully immunized. METHODS:We identified children <18 year...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3900

    authors: Olarte L,Ampofo K,Stockmann C,Mason EO,Daly JA,Pavia AT,Byington CL

    更新日期:2013-07-01 00:00:00

  • Diagnostic imaging and negative appendectomy rates in children: effects of age and gender.

    abstract:BACKGROUND AND OBJECTIVES:Diagnostic imaging is often used in the evaluation of children with possible appendicitis. The utility of imaging may vary according to a patient's age and gender. The objectives of this study were (1) to examine the use of computed tomography (CT) and ultrasound for age and gender subgroups o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-3375

    authors: Bachur RG,Hennelly K,Callahan MJ,Chen C,Monuteaux MC

    更新日期:2012-05-01 00:00:00

  • Philosophic objection to vaccination as a risk for tetanus among children younger than 15 years.

    abstract:OBJECTIVES:Although safe and effective vaccines are available to protect against tetanus in the United States and vaccination rates are high, cases of tetanus among children continue to occur. The objectives of this article are to describe reported cases of tetanus in children in the United States and to identify the r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.1.e2

    authors: Fair E,Murphy TV,Golaz A,Wharton M

    更新日期:2002-01-01 00:00:00

  • Aminoglycoside-based triple-antibiotic therapy versus monotherapy for children with ruptured appendicitis.

    abstract:OBJECTIVE:We conducted a retrospective cohort study to compare the use of triple therapy versus monotherapy for children and adolescents with perforated appendicitis and to determine whether there has been a transition to monotherapy within the freestanding children's hospitals that contribute to the Pediatric Health I...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2006-2040

    authors: Goldin AB,Sawin RS,Garrison MM,Zerr DM,Christakis DA

    更新日期:2007-05-01 00:00:00

  • Munchausen's syndrome by proxy (child abuse) presenting as apparent autoerythrocyte sensitization syndrome: an unusual presentation of Polle syndrome.

    abstract::Munchausen's syndrome was initially described in 1951. It has become increasingly recognized since that time. Recently, Munchausen's syndrome by proxy or Polle syndrome has been described. In this disease entity, a parent causes a factitious disease in a child. The disease may require extensive medical testing and the...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Clark GD,Key JD,Rutherford P,Bithoney WG

    更新日期:1984-12-01 00:00:00

  • Obtaining consent from both parents for pediatric research: what does "reasonably available" mean?

    abstract:OBJECTIVE:Circumstances surrounding parental availability and decision-making were examined in the setting of a research protocol involving newborn screening (NBS) for fragile X syndrome, in which the institutional review board (IRB) had determined that consent (permission) was required from both parents. METHODS:A su...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1278

    authors: Nelson DK,Skinner D,Guarda S,Choudhury S,Sideris J,Barnum L,Ten Haagen K,Heyward Q,Bailey DB Jr

    更新日期:2013-01-01 00:00:00

  • Toe tourniquet syndrome in association with maternal hair loss.

    abstract::Increased hair loss a few months after delivering an infant is a common postpartum condition known as telogen effluvium. A much less common condition involving young infants is the hair-thread tourniquet syndrome, or toe tourniquet syndrome, which involves hair or thread becoming so tightly wrapped around an appendage...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.3.685

    authors: Strahlman RS

    更新日期:2003-03-01 00:00:00

  • Neonatal therapeutic intervention scoring system: a therapy-based severity-of-illness index.

    abstract::Severity-of-illness scales have proven valuable in assessing clinical outcomes and resource consumption in adult and pediatric intensive care, but they have been less extensively developed for neonatal care. The National Therapeutic Intervention Scoring System (NTISS) was created by modifying the Therapeutic Intervent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gray JE,Richardson DK,McCormick MC,Workman-Daniels K,Goldmann DA

    更新日期:1992-10-01 00:00:00

  • Pediatric advance care planning: a systematic review.

    abstract:BACKGROUND AND OBJECTIVES:Advance care planning (ACP) is increasingly regarded as the gold standard in the care of patients with life-limiting illnesses. Research has focused on adults, but ACP is also being practiced in pediatrics. We conducted a systematic review on empirical literature on pediatric ACP (pACP) to ass...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2012-2394

    authors: Lotz JD,Jox RJ,Borasio GD,Führer M

    更新日期:2013-03-01 00:00:00

  • Yersinia enterocolitica arthritis.

    abstract::Human infections with Yersinia were first recognized and reported in upper New York State almost 40 years ago. Recently, there have been increasing numbers of reports from Scandinavia of episodes of polyarthritis associated with Yersinia infections. A 6-month-old girl from upstate New York had a fever of 40 C for two ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jacobs JC

    更新日期:1975-02-01 00:00:00

  • Infection in the first 2 years of life and autism spectrum disorders.

    abstract:OBJECTIVE:The purpose of this work was to investigate the association between infections in the first 2 years and subsequent diagnosis of autism spectrum disorders. METHODS:We conducted a case-control study among children born at Kaiser Permanente Northern California from 1995 to 1999. Case subjects (n = 403) were chi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1788

    authors: Rosen NJ,Yoshida CK,Croen LA

    更新日期:2007-01-01 00:00:00

  • Effects of continuity of care in infancy on receipt of lead, anemia, and tuberculosis screening.

    abstract:OBJECTIVES:The goals were (1) to examine the influence of continuity of care on delivery of lead, anemia, and tuberculosis screening in a cohort of Medicaid-enrolled children, (2) to determine whether well-child care continuity had a greater effect than continuity for all ambulatory visits, and (3) to investigate which...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1497

    authors: Flores AI,Bilker WB,Alessandrini EA

    更新日期:2008-03-01 00:00:00

  • Is a "wage-payment" model for research participation appropriate for children?

    abstract:OBJECTIVE:Our goal was to evaluate the applicability of a "wage-payment" model to inducements for children to participate in research. SUBJECTS AND METHODS:We interviewed 42 children and adolescents between the ages of 4 and 16 years who had diabetes, asthma, seizures, or no chronic medical condition. The interview ex...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1813

    authors: Bagley SJ,Reynolds WW,Nelson RM

    更新日期:2007-01-01 00:00:00

  • Establishing New Norms for Developmental Milestones.

    abstract:BACKGROUND AND OBJECTIVES:Pediatric surveillance of young children depends on providers' assessment of developmental milestones, yet normative data are sparse. Our objectives were to develop new norms for common milestones to aid in clinical interpretation of milestone attainment. METHODS:We analyzed responses to the ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0374

    authors: Sheldrick RC,Schlichting LE,Berger B,Clyne A,Ni P,Perrin EC,Vivier PM

    更新日期:2019-12-01 00:00:00

  • Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.

    abstract:OBJECTIVE:To investigate the effect of vitamin D3 supplementation on the incidence and risk for first and recurrent diarrheal illnesses among children in Kabul, Afghanistan. METHODS:This double-blind placebo-controlled trial randomized 3046 high-risk 1- to 11-month-old infants to receive 6 quarterly doses of oral vita...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2012-3986

    authors: Aluisio AR,Maroof Z,Chandramohan D,Bruce J,Mughal MZ,Bhutta Z,Walraven G,Masher MI,Ensink JH,Manaseki-Holland S

    更新日期:2013-10-01 00:00:00

  • Do obese inner-city children with asthma have more symptoms than nonobese children with asthma?

    abstract:OBJECTIVE:To test whether obesity is associated with decreased peak expiratory flow rates (PEFR), increased asthma symptoms, and increased health service use. DESIGN/METHODS:Secondary analysis of data from a cross-sectional convenience sample. SETTING:Emergency departments (EDs) and primary care clinics in 8 inner-ci...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.6.1436

    authors: Belamarich PF,Luder E,Kattan M,Mitchell H,Islam S,Lynn H,Crain EF

    更新日期:2000-12-01 00:00:00

  • Errors and correlates in parental recall of child immunizations: effects on vaccination coverage estimates.

    abstract:OBJECTIVE:We evaluated the accuracy of parental recall of children's immunization histories as compared with provider records and examined how errors in parental recall correlate with sociodemographic characteristics. DESIGN:The validation study was part of a population-based household survey designed to assess immuni...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.5.e3

    authors: Suarez L,Simpson DM,Smith DR

    更新日期:1997-05-01 00:00:00

  • Children riding in the back of pickup trucks: a neglected safety issue.

    abstract::Motor vehicle-related trauma is the leading cause of death in children in the United States. All states have pediatric restraint requirements for passenger vehicles to help prevent these deaths and injuries. Only a few states, however, possess safety laws or restrictions for passengers who ride in the back of pickup t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Woodward GA,Bolte RG

    更新日期:1990-11-01 00:00:00

  • Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Cryotherapy for Retinopathy of Prematurity Cooperative Group.

    abstract::We report the preliminary 3-month outcome of a multicenter randomized trial of cryotherapy for treatment of retinopathy of prematurity (ROP). Transscleral cryotherapy to the avascular retina was applied to one randomly selected eye when there was threshold disease (defined as five or more contiguous or eight cumulativ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors:

    更新日期:1988-05-01 00:00:00

  • Family history predicts stress fracture in active female adolescents.

    abstract:OBJECTIVE:Increased physical activity and menstrual irregularity have been associated with increased risk for stress fracture among adult women active in athletics. The purposes of this study were to determine whether menstrual irregularity is also a risk factor for stress fracture in active female adolescents and to e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-2145

    authors: Loud KJ,Micheli LJ,Bristol S,Austin SB,Gordon CM

    更新日期:2007-08-01 00:00:00

  • Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn.

    abstract:OBJECTIVE:To determine the clinical role of inhaled nitric oxide (iNO) in the treatment of persistent pulmonary hypertension of the newborn (PPHN). STUDY DESIGN:Prospective open observational clinical study. SETTING:A regional cardiac and pediatric intensive care unit. METHODS:Twenty-five consecutive near-term neona...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Goldman AP,Tasker RC,Haworth SG,Sigston PE,Macrae DJ

    更新日期:1996-10-01 00:00:00

  • Efficacy of psychosocial group intervention for children with chronic illness and their parents.

    abstract:OBJECTIVE:To investigate the efficacy of a cognitive-behavioral group intervention for children with chronic illnesses and to test the effect of an added parent component. METHODS:Children (n = 194) and their parents participated in a multicenter randomized clinical trial comparing a child-only intervention and a pare...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2012-2222

    authors: Scholten L,Willemen AM,Last BF,Maurice-Stam H,van Dijk EM,Ensink E,Zandbelt N,van der Hoop-Mooij A,Schuengel C,Grootenhuis MA

    更新日期:2013-04-01 00:00:00

  • Health outcomes of a community-based therapy program for children with cancer--a shared-management approach.

    abstract::Critical to providing cancer therapy to children in rural areas is finding dependable sources of therapy near the patients' homes. In this study, comparison was made of 668 visits by 24 patients to nearby private practitioners, who carried out 70% of the therapy, with 712 visits by 22 other patients for whom all care ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kisker CT,Strayer F,Wong K,Clarke W,Strauss R,Tannous R,Janco R,Spevak J

    更新日期:1980-12-01 00:00:00

  • SunSafe in the Middle School Years: a community-wide intervention to change early-adolescent sun protection.

    abstract:OBJECTIVE:Rising rates of skin cancer associated with early-life sun exposure make it important to improve adolescent sun-protection practices. Our study objective was to determine if a multicomponent community-wide intervention could alter the decline in sun protection that begins in early adolescence. METHODS:A rand...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2006-1579

    authors: Olson AL,Gaffney C,Starr P,Gibson JJ,Cole BF,Dietrich AJ

    更新日期:2007-01-01 00:00:00

  • A block rotation in community pediatrics.

    abstract:OBJECTIVES:To develop, implement, and evaluate a 1-month block rotation in community pediatrics. INTERVENTIONS:Faculty from University of California San Diego and Naval Medical Center San Diego developed a combined and integrated curriculum for second-year residents in community pediatrics. Resident activities include...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Shope TR,Bradley BJ,Taras HL

    更新日期:1999-07-01 00:00:00

  • Identifying the Misshapen Head: Craniosynostosis and Related Disorders.

    abstract::Pediatric care providers, pediatricians, pediatric subspecialty physicians, and other health care providers should be able to recognize children with abnormal head shapes that occur as a result of both synostotic and deformational processes. The purpose of this clinical report is to review the characteristic head shap...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-015511

    authors: Dias MS,Samson T,Rizk EB,Governale LS,Richtsmeier JT,SECTION ON NEUROLOGIC SURGERY, SECTION ON PLASTIC AND RECONSTRUCTIVE SURGERY.

    更新日期:2020-09-01 00:00:00