Vitamin D₃supplementation and childhood diarrhea: a randomized controlled trial.

Abstract:

OBJECTIVE:To investigate the effect of vitamin D3 supplementation on the incidence and risk for first and recurrent diarrheal illnesses among children in Kabul, Afghanistan. METHODS:This double-blind placebo-controlled trial randomized 3046 high-risk 1- to 11-month-old infants to receive 6 quarterly doses of oral vitamin D3 (cholecalciferol 100000 IU) or placebo in inner city Kabul. Data on diarrheal episodes (≥ 3 loose/liquid stools in 24 hours) was gathered through active and passive surveillance over 18 months of follow-up. Time to first diarrheal illness was analyzed by using Kaplan-Meier plots. Incidence rates and hazard ratios (HRs) were calculated by using recurrent event Poisson regression models. RESULTS:No significant difference existed in survival time to first diarrheal illness (log rank P = .55). The incidences of diarrheal episodes were 3.43 (95% confidence interval [CI], 3.28-3.59) and 3.59 per child-year (95% CI, 3.44-3.76) in the placebo and intervention arms, respectively. Vitamin D3 supplementation was found to have no effect on the risk for recurrent diarrheal disease in either intention-to-treat (HR, 1.05; 95% CI, 0.98-1.17; P = .15) or per protocol (HR, 1.05; 95% CI, 0.98-1.12; P = .14) analyses. The lack of preventive benefit remained when the randomized population was stratified by age groups, nutritional status, and seasons. CONCLUSIONS:Quarterly supplementation with vitamin D3 conferred no reduction on time to first illness or on the risk for recurrent diarrheal disease in this study. Similar supplementation to comparable populations is not recommended. Additional research in alternative settings may be helpful in elucidating the role of vitamin D3 supplementation for prevention of diarrheal diseases.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Aluisio AR,Maroof Z,Chandramohan D,Bruce J,Mughal MZ,Bhutta Z,Walraven G,Masher MI,Ensink JH,Manaseki-Holland S

doi

10.1542/peds.2012-3986

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

e832-40

issue

4

eissn

0031-4005

issn

1098-4275

pii

peds.2012-3986

journal_volume

132

pub_type

杂志文章,随机对照试验
  • A Quality Improvement Initiative To Improve Postdischarge Antimicrobial Adherence.

    abstract:OBJECTIVES:Bedside delivery of discharge medications improves caregiver understanding and experience. Less is known about its impact on medication adherence. We aimed to improve antimicrobial adherence by increasing on-time first home doses for patients discharged from the pediatric hospital medicine service from 33% t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-2413

    authors: Gupta S,Winckler B,Lopez MA,Costilla M,McCarthy J,Wagner J,Broderick A,French K,Le B,Lo HY

    更新日期:2021-01-01 00:00:00

  • Fatal and nonfatal farm injuries to children and adolescents in the United States.

    abstract::Agriculture is the second most dangerous occupation in the United States, and unlike other occupations, children make up a significant portion of the work force. This study presents national data on the morbidity and mortality due to farm injuries to children and adolescents less than or equal to 19 years of age. Data...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Rivara FP

    更新日期:1985-10-01 00:00:00

  • Reducing Variation in the Management of Apnea of Prematurity in the Intensive Care Nursery.

    abstract:BACKGROUND:Premature infants have bradycardia and/or desaturation events due to apnea of prematurity that resolve as the infants mature. Despite American Academy of Pediatrics guidelines recommending a standard "event-free" period before discharge, length of observation in our Intensive Care Nursery was variable. By Ju...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0861

    authors: Coughlin K,Posencheg M,Orfe L,Zachritz W,Meadow J,Yang K,Christ L

    更新日期:2020-02-01 00:00:00

  • Late-onset neutropenia in very low birth weight infants.

    abstract:BACKGROUND:Neutropenia, defined as absolute neutrophil count (ANC) <1500/mm(3), affects 6% to 58% of premature infants in the first week of life. This early-onset neutropenia in premature infants has previously been correlated with sepsis, maternal hypertension, severe asphyxia, and periventricular hemorrhage. Late-ons...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.4.e55

    authors: Omar SA,Salhadar A,Wooliever DE,Alsgaard PK

    更新日期:2000-10-01 00:00:00

  • Atlantoaxial instability in individuals with Down syndrome: epidemiologic, radiographic, and clinical studies.

    abstract::Atlantoaxial instability is a relatively frequent finding in individuals with Down syndrome. We examined 404 patients with this chromosome disorder and observed their atlanto-dens intervals and spinal canal widths to be significantly different from children without Down syndrome. Significant differences were also note...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Pueschel SM,Scola FH

    更新日期:1987-10-01 00:00:00

  • Trends in Health Care Spending for Children in Medicaid With High Resource Use.

    abstract:OBJECTIVES:To assess characteristics associated with health care spending trends among child high resource users in Medicaid. METHODS:This retrospective analysis included 48 743 children ages 1 to 18 years continuously enrolled from 2009-2013 in 10 state Medicaid programs (Truven MarketScan Medicaid Database) also in ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-0682

    authors: Agrawal R,Hall M,Cohen E,Goodman DM,Kuo DZ,Neff JM,O'Neill M,Thomson J,Berry JG

    更新日期:2016-10-01 00:00:00

  • Twenty-year follow-up of antenatal corticosteroid treatment.

    abstract:OBJECTIVE:To study late side effects of antenatal corticosteroid treatment on health and sexual development in subjects 20 to 22 years old. METHODS:A follow-up study among young adults whose mothers had, because of a threatening delivery, participated in a randomized, double-blind, placebo- controlled trial of betamet...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.105.6.e77

    authors: Dessens AB,Haas HS,Koppe JG

    更新日期:2000-06-01 00:00:00

  • Metopic craniostenosis as a consequence of fetal head constraint: two interesting experiments of nature.

    abstract::Two instances of metopic craniosynostosis provide dramatic experiments of nature which implicate fetal head constraint as one cause of early sutural fusion. The presumed restriction of growth stretch at the metopic suture in one instance was due to a bicornuate uterus in which the fetal head was markedly constrained. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Graham JM Jr,Smith DW

    更新日期:1980-05-01 00:00:00

  • Epidemiology of juvenile chronic arthritis in southwestern Sweden: a 5-year prospective population study.

    abstract::Previous epidemiological studies of juvenile chronic arthritis (JCA) report divergent results owing to differences in diagnostic criteria, patient retrieval, and study designs. To investigate incidence and prevalence of JCA in a total population, this prospective survey was performed in southwestern Sweden between 198...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gäre BA,Fasth A

    更新日期:1992-12-01 00:00:00

  • Circumcision policy statement.

    abstract::Male circumcision is a common procedure, generally performed during the newborn period in the United States. In 2007, the American Academy of Pediatrics (AAP) formed a multidisciplinary task force of AAP members and other stakeholders to evaluate the recent evidence on male circumcision and update the Academy's 1999 r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1989

    authors: American Academy of Pediatrics Task Force on Circumcision.

    更新日期:2012-09-01 00:00:00

  • Feasibility and preliminary outcomes of a scalable, community-based treatment of childhood obesity.

    abstract:OBJECTIVE:Clinic-based treatments of childhood obesity are effective but typically have limited reach and are costly. In this study, we evaluated the effects of a scalable weight management program for children and teenagers. METHODS:Participants were 155 children and their parent/guardian. Children had a mean ± SD ag...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.2012-0344

    authors: Foster GD,Sundal D,McDermott C,Jelalian E,Lent MR,Vojta D

    更新日期:2012-10-01 00:00:00

  • Hypoglycemia in small-for-dates newborn infants.

    abstract::In 24% (18 out of 76) small-for-dates a "significant" though asymptomatic hypoglycemia was demonstrated during the first six hours of life. The cord blood glucose concentration was lower in the hypoglycemic compared to that of the small-for-date normoglycemic group. In the hypoglycemic infants, the disappearance rate ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: de Leeuw R,de Vries IJ

    更新日期:1976-07-01 00:00:00

  • Obtaining consent from both parents for pediatric research: what does "reasonably available" mean?

    abstract:OBJECTIVE:Circumstances surrounding parental availability and decision-making were examined in the setting of a research protocol involving newborn screening (NBS) for fragile X syndrome, in which the institutional review board (IRB) had determined that consent (permission) was required from both parents. METHODS:A su...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1278

    authors: Nelson DK,Skinner D,Guarda S,Choudhury S,Sideris J,Barnum L,Ten Haagen K,Heyward Q,Bailey DB Jr

    更新日期:2013-01-01 00:00:00

  • Impact of income and income inequality on infant health outcomes in the United States.

    abstract:OBJECTIVES:The goal was to investigate the relationships of income and income inequality with neonatal and infant health outcomes in the United States. METHODS:The 2000-2004 state data were extracted from the Kids Count Data Center. Health indicators included proportion of preterm births (PTBs), proportion of infants ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2009-3378

    authors: Olson ME,Diekema D,Elliott BA,Renier CM

    更新日期:2010-12-01 00:00:00

  • National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985.

    abstract::The number of cases of Reye syndrome reported annually to the Centers for Disease Control declined markedly between 1980 and 1985. In this article, we present pharmaceutical marketing research data that suggest sharp decreases in the use and purchase of children's aspirin between 1980 and 1985. These trends appear to ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Arrowsmith JB,Kennedy DL,Kuritsky JN,Faich GA

    更新日期:1987-06-01 00:00:00

  • Iatrogenic arteriovenous fistula after multiple arterial punctures.

    abstract::Multiple arterial punctures in the neonate can result in iatrogenic arteriovenous fistula formation. In one case, a 3-month-old infant who had been born prematurely was noted to have physical findings consistent with arteriovenous malformation following approximately 90 arterial blood gas determinations over a 13-week...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ontell SJ,Gauderer MW

    更新日期:1985-07-01 00:00:00

  • A prospective study of the role of depression in the development and persistence of adolescent obesity.

    abstract:BACKGROUND:Adolescent obesity is a strong predictor of adult obesity, and adult obesity has been associated with depression, especially in women. Studies have also suggested an association between depression in adolescence and higher body mass index (BMI) in adulthood. Whether depression leads to obesity or obesity cau...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.3.497

    authors: Goodman E,Whitaker RC

    更新日期:2002-09-01 00:00:00

  • Lamotrigine adjunctive therapy among children and adolescents with primary generalized tonic-clonic seizures.

    abstract:CONTEXT AND OBJECTIVE:Primary generalized tonic-clonic seizures are relatively more common among children than among adults. Primary generalized tonic-clonic seizures are associated with increased risk of injury and death. Therefore, effective control of primary generalized tonic-clonic seizures is necessary to reduce ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2006-0148

    authors: Trevathan E,Kerls SP,Hammer AE,Vuong A,Messenheimer JA

    更新日期:2006-08-01 00:00:00

  • Imbalance between production and conjugation of bilirubin: a fundamental concept in the mechanism of neonatal jaundice.

    abstract:OBJECTIVE:The objective of this study was to evaluate the roles of production and conjugation of bilirubin, individually and in combination, in the mechanism of neonatal jaundice. METHODS:A cohort of healthy, term male newborns was sampled on the third day of life, coincident with routine metabolic screening, for bloo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.4.e47

    authors: Kaplan M,Muraca M,Hammerman C,Rubaltelli FF,Vilei MT,Vreman HJ,Stevenson DK

    更新日期:2002-10-01 00:00:00

  • Serum immunoreactive pancreatic lipase and cationic trypsinogen for the assessment of exocrine pancreatic function in older patients with cystic fibrosis.

    abstract::Indirect and qualitative tests of pancreatic function are commonly used to screen patients with cystic fibrosis for pancreatic insufficiency. In an attempt to develop a more quantitative assessment, we compared the usefulness of measuring serum pancreatic lipase using a newly developed enzyme-linked immunosorbent immu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Cleghorn G,Benjamin L,Corey M,Forstner G,Dati F,Durie P

    更新日期:1986-03-01 00:00:00

  • Iron-deficiency anemia in Castleman disease: implication of the interleukin 6/hepcidin pathway.

    abstract::In addition to occasional autoimmune hemolytic anemia, unexplained iron-deficiency anemia has been reported in childhood Castleman disease (CD). The recent discovery of hepcidin has regenerated the research on iron metabolism. This hormone is a key regulator of iron homeostasis, mainly by inhibiting intestinal iron ab...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1123

    authors: Arlet JB,Hermine O,Darnige L,Ostland V,Westerman M,Badoual C,Pouchot J,Capron L

    更新日期:2010-12-01 00:00:00

  • Comparison of rifampin and ampicillin in day care center contacts of Haemophilus influenzae type b disease.

    abstract::A prospective, randomized, crossover trial was conducted comparing therapy with rifampin to therapy with ampicillin in eradicating Haemophilus influenzae type b carriage. Twenty-eight carriers were identified in a day care center following exposure to a patient with H influenzae type b meningitis; 26 children were ran...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Gessert C,Granoff DM,Gilsdorf J

    更新日期:1980-07-01 00:00:00

  • Erythema Marginatum as an Early Symptom of Hereditary Angioedema: Case Report of 2 Newborns.

    abstract::Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare genetic disease that causes recurrent swelling attacks that may affect various body tissues. Angioedematous attacks can be fatal in the case of upper airway edema and are often preceded by prodromal symptoms like erythema marginatum. Initial s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2411

    authors: Martinez-Saguer I,Farkas H

    更新日期:2016-02-01 00:00:00

  • Total population estimate of newborn special-care bed needs.

    abstract::In 1977, 7% of the 38,855 infants born in Utah were estimated to have required a total of 27,439 special-care hospital days. About half (53%) were mildly ill; their average length of stay was 4.6 days, or 24% of the total hospital-days. Another 20% of the infants had intermediate illness, with a 12-day average stay, o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jung AL,Streeter NS

    更新日期:1985-06-01 00:00:00

  • Delivery Room Continuous Positive Airway Pressure and Pneumothorax.

    abstract:BACKGROUND:In 2011, the Neonatal Resuscitation Program (NRP) added consideration of continuous positive airway pressure (CPAP) for spontaneously breathing infants with labored breathing or hypoxia in the delivery room (DR). The objective of this study was to determine if DR-CPAP is associated with symptomatic pneumotho...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0756

    authors: Smithhart W,Wyckoff MH,Kapadia V,Jaleel M,Kakkilaya V,Brown LS,Nelson DB,Brion LP

    更新日期:2019-09-01 00:00:00

  • Predicting the outcome of neonatal bacterial meningitis.

    abstract:OBJECTIVE:To build predictive models of severe adverse outcome at various times in the course of neonatal bacterial meningitis. STUDY DESIGN:Retrospective cohort study with follow-up to a minimum age of 1 year of term and near-term infants, admitted between 1979 and 1998 to a regional tertiary care center. Predictors ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.3.477

    authors: Klinger G,Chin CN,Beyene J,Perlman M

    更新日期:2000-09-01 00:00:00

  • Change in prevalence of congenital defects in children with Prader-Willi syndrome.

    abstract:OBJECTIVE:The aim of this study was to assess the prevalence of congenital defects observed in patients with Prader-Willi syndrome (PWS) and to compare this prevalence with that described in the general population. In addition, these findings were correlated with the different etiologic subtypes. METHODS:A total of 18...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1103

    authors: Torrado M,Foncuberta ME,Perez MF,Gravina LP,Araoz HV,Baialardo E,Chertkoff LP

    更新日期:2013-02-01 00:00:00

  • Quality of primary care and subsequent pediatric emergency department utilization.

    abstract:OBJECTIVE:Our objective was to determine whether parent-reported, high-quality primary care was associated with decreased nonurgent pediatric emergency department utilization. METHODS:A retrospective analysis of prospectively collected data for a cohort of children from the 2000-2001 and 2001-2002 Medical Expenditure ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3518

    authors: Brousseau DC,Hoffmann RG,Nattinger AB,Flores G,Zhang Y,Gorelick M

    更新日期:2007-06-01 00:00:00

  • A parent questionnaire for developmental screening in infants born late and moderately preterm.

    abstract:BACKGROUND:The Parent Report of Children's Abilities-Revised (PARCA-R) is a questionnaire for assessing cognitive and language development in very preterm infants. Given the increased risk of developmental delay in infants born late and moderately preterm (LMPT; 32-36 weeks), this study aimed to validate this questionn...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0266

    authors: Blaggan S,Guy A,Boyle EM,Spata E,Manktelow BN,Wolke D,Johnson S

    更新日期:2014-07-01 00:00:00

  • Prone and supine positioning effects on energy expenditure and behavior of low birth weight neonates.

    abstract::The effect of body position (supine v prone) on energy expenditure and behavior of 42 healthy low birth weight (920 to 1,760 g) infants was evaluated in 66 studies. Each infant was randomly assigned to the supine or prone position for the first three-hour epoch; the position was reversed for the second three-hour epoc...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Masterson J,Zucker C,Schulze K

    更新日期:1987-11-01 00:00:00