Comparison of rifampin and ampicillin in day care center contacts of Haemophilus influenzae type b disease.

Abstract:

:A prospective, randomized, crossover trial was conducted comparing therapy with rifampin to therapy with ampicillin in eradicating Haemophilus influenzae type b carriage. Twenty-eight carriers were identified in a day care center following exposure to a patient with H influenzae type b meningitis; 26 children were randomly assigned to treatment with either ampicillin (100 mg/kg for five days) or rifampin (20 mg/kg for four days). Cultures were repeated two and four days after discontinuing therapy. In the initial trial, 6/17 children (35%) remained culture positive after treatment with ampicillin compared to 0/9 children treated with rifampin (P = .106). The six children who were ampicillin treatment failures had H influenzae type b isolates sensitive to that drug. These children were subsequently treated with rifampin and their cultures became negative. (For both trials, P = .027). Repeat cultures 30 days after therapy in 20 treated children revealed one culture positive for H influenzae type b. No further cases developed in the day care center (four months of follow-up). These data suggest that rifampin may be more effective than ampicillin in chemoprophylaxis of contacts of H influenzae type b disease.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Gessert C,Granoff DM,Gilsdorf J

subject

Has Abstract

pub_date

1980-07-01 00:00:00

pages

1-4

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

66

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:OBJECTIVES:To identify predictors of attention-deficit/hyperactivity disorder (ADHD) medication continuity, hypothesizing greater continuity among children with (1) greater child acceptance of treatment, (2) parent belief in longer time course for ADHD, (3) positive differential between parent-perceived need for and co...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2580

    authors: Brinkman WB,Sucharew H,Majcher JH,Epstein JN

    更新日期:2018-06-01 00:00:00

  • Steroid use among adolescents: longitudinal findings from Project EAT.

    abstract:OBJECTIVE:We examined the prevalence, persistence, secular and longitudinal trends, and predictors of steroid use in a diverse sample of adolescents. PARTICIPANTS AND METHODS:Data are from Project EAT-II (Eating Among Teens), a 5-year longitudinal study of eating, activity, weight, and related variables in 2516 middle...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-2529

    authors: vandenBerg P,Neumark-Sztainer D,Cafri G,Wall M

    更新日期:2007-03-01 00:00:00

  • Treatment of child and adolescent obesity: reports from pediatricians, pediatric nurse practitioners, and registered dietitians.

    abstract:OBJECTIVE:The primary aim of this study was to identify interventions used by pediatric health care providers in treatment of overweight children and adolescents to identify provider educational needs. A secondary aim was to examine the association of certain provider characteristics with recommended evaluation practic...

    journal_title:Pediatrics

    pub_type: 评论,杂志文章

    doi:

    authors: Barlow SE,Trowbridge FL,Klish WJ,Dietz WH

    更新日期:2002-07-01 00:00:00

  • Serious air rifle injuries in children.

    abstract::Seven potentially lethal air gun injuries in children are reported. Multiple-pump action air rifles have penetration velocities far in excess of the classic Daisy "BB" guns. However, these lethal weapons are sold to be used by children. Lack of effective regulatory legislation coupled with parental ignorance will cont...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Blocker S,Coln D,Chang JH

    更新日期:1982-06-01 00:00:00

  • The changing composition of the pediatric medical subspecialty workforce.

    abstract:OBJECTIVES:To characterize the composition of the pediatric subspecialty workforce in terms of the distribution of women and international medical graduates (IMGs) across pediatric medical subspecialties and to determine whether the proportions of board-certified pediatric subspecialists who are women or IMGs differ be...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2446

    authors: Mayer ML,Preisser JS

    更新日期:2005-10-01 00:00:00

  • Cerebral blood flow velocity changes in preterm infants after a single dose of indomethacin: duration of its effect.

    abstract::Indomethacin decreases cerebral blood flow velocity and blood flow in the preterm infant. The duration of this negative effect has not been established. Cerebral blood flow velocity was evaluated in 24 preterm infants with symptomatic patent ductus arteriosus before and during the first 12 hours after a single intrave...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Van Bel F,Van de Bor M,Stijnen T,Baan J,Ruys JH

    更新日期:1989-11-01 00:00:00

  • Safety and efficacy of long-term diet and diet plus bile acid-binding resin cholesterol-lowering therapy in 73 children heterozygous for familial hypercholesterolemia.

    abstract::Our specific aim was to examine the efficacy and safety of long-term cholesterol-lowering diet and bile acid-binding resin therapy in 73 children heterozygous for familial hypercholesterolemia (FH). We prospectively followed accretion of height and weight in 40 FH children for 5.8 years on diet alone and in 33 FH chil...

    journal_title:Pediatrics

    pub_type: 杂志文章,收录出版

    doi:

    authors: Glueck CJ,Mellies MJ,Dine M,Perry T,Laskarzewski P

    更新日期:1986-08-01 00:00:00

  • Digital Advertising to Children.

    abstract::Advertising to children and teenagers is a multibillion-dollar industry. This policy statement reviews the forms of advertising that children and teenagers encounter, including newer forms of digital marketing, such as sponsored content, influencers, data collection, persuasive design, and personalized behavioral mark...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-1681

    authors: Radesky J,Chassiakos YLR,Ameenuddin N,Navsaria D,COUNCIL ON COMMUNICATION AND MEDIA.

    更新日期:2020-07-01 00:00:00

  • Practices of unregulated tanning facilities in Missouri: implications for statewide legislation.

    abstract:BACKGROUND:The incidence of skin cancer has increased in the United States, concomitant with increased UV radiation (UVR) exposure among young adults. We examined whether tanning facilities in Missouri, a state without indoor-tanning regulations, acted in accordance with the Food and Drug Administration's recommendatio...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2012-1781

    authors: Balaraman B,Biesbroeck LK,Lickerman SH,Cornelius LA,Jeffe DB

    更新日期:2013-03-01 00:00:00

  • Parent-Adolescent Agreement About Adolescents' Suicidal Thoughts.

    abstract::: media-1vid110.1542/5972300121001PEDS-VA_2018-1771Video Abstract OBJECTIVES: To examine agreement between parent and adolescent reports of adolescents' suicidal thoughts and explore demographic and clinical factors associated with agreement in a large community sample. METHODS:Participants included 5137 adolescents ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-1771

    authors: Jones JD,Boyd RC,Calkins ME,Ahmed A,Moore TM,Barzilay R,Benton TD,Gur RE

    更新日期:2019-02-01 00:00:00

  • Febrile exudative tonsillitis: viral or streptococcal?

    abstract::A prospective 1-year study of acute febrile exudative tonsillitis in 110 children was carried out. Viral infection was associated with 42% of the cases, beta-hemolytic streptococci with 31% (12% group A), Mycoplasma pneumoniae with 5%, and unknown cause with 35%. More than one agent was implicated in 14% of the cases....

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Putto A

    更新日期:1987-07-01 00:00:00

  • Advanced Ultrasound Techniques for Pediatric Imaging.

    abstract::Ultrasound has become a useful tool in the workup of pediatric patients because of the highly convenient, cost-effective, and safe nature of the examination. With rapid advancements in anatomic and functional ultrasound techniques over the recent years, the diagnostic and interventional utility of ultrasound has risen...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2018-2609

    authors: Hwang M,Piskunowicz M,Darge K

    更新日期:2019-03-01 00:00:00

  • Life-threatening sepsis caused by Burkholderia cepacia from contaminated intravenous flush solutions prepared by a compounding pharmacy in another state.

    abstract::We report 2 life-threatening cases of Burkholderia cepacia sepsis caused by infusate contamination during compounding. Bacterial isolates from the patients' blood cultures and the infusate were indistinguishable by pulsed-field gel electrophoresis. Proper quality controls at a local and national level are important fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2617

    authors: Held MR,Begier EM,Beardsley DS,Browne FA,Martinello RA,Baltimore RS,McDonald LC,Jensen B,Hadler JL,Dembry LM

    更新日期:2006-07-01 00:00:00

  • Pediatric chest pain: a prospective study.

    abstract::Previous studies of childhood chest pain have been retrospective or considered only limited age groups or referred patients. In this study, all children who were admitted to the emergency department with chest pain were evaluated prospectively. Patients with ill-defined chest pain had ECGs and echocardiograms performe...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Selbst SM,Ruddy RM,Clark BJ,Henretig FM,Santulli T Jr

    更新日期:1988-09-01 00:00:00

  • Vitamin A delivery in total parenteral nutrition solution.

    abstract::Vitamin A delivery was studied in total parenteral nutrition as used for neonates. Although the data show that the patient receives more vitamin A than dictated by known needs or advised intakes, delivery to the patient is roughly one third of that which would be predicted from the initial intravenous solution composi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hartline JV,Zachman RD

    更新日期:1976-09-01 00:00:00

  • Population case-control study of cerebral palsy: neonatal predictors for low-risk term singletons.

    abstract:OBJECTIVES:For singletons with cerebral palsy (CP) who were born at term, the goals were (1) to determine the proportion not admitted to a Special Care Unit/NICU (NICU), (2) to compare clinical descriptions of those admitted to NICUs and those not admitted, and (3) to identify neonatal predictors of CP among those not ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1894

    authors: McIntyre S,Badawi N,Brown C,Blair E

    更新日期:2011-03-01 00:00:00

  • Highly somatizing young adolescents and the risk of depression.

    abstract:OBJECTIVE:To determine if high levels of somatization symptoms in 13- to 16-year-olds from the general population predict risk of major depression and other psychiatric disorders 4 years later. METHOD:Cohort study, using interview and self-report survey data from the 1983 Ontario Child Health Study (OCHS) and 1987 OCH...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.6.1203

    authors: Zwaigenbaum L,Szatmari P,Boyle MH,Offord DR

    更新日期:1999-06-01 00:00:00

  • From concept to application: the impact of a community-wide intervention to improve the delivery of preventive services to children.

    abstract:OBJECTIVE:To improve health outcomes of children, the US Maternal and Child Health Bureau has recommended more effective organization of preventive services within primary care practices and more coordination between practices and community-based agencies. However, applying these recommendations in communities is chall...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.108.3.e42

    authors: Margolis PA,Stevens R,Bordley WC,Stuart J,Harlan C,Keyes-Elstein L,Wisseh S

    更新日期:2001-09-01 00:00:00

  • Duration of protection after infant hepatitis B vaccination series.

    abstract:BACKGROUND:Little is known about duration of protection after the infant primary series of hepatitis B (HB) vaccine in settings of low HB endemicity. This study sought to determine the proportion of adolescents immunized as infants who had protective titers of antibody to hepatitis B surface antigen (anti-HBs) before a...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2013-2940

    authors: Middleman AB,Baker CJ,Kozinetz CA,Kamili S,Nguyen C,Hu DJ,Spradling PR

    更新日期:2014-06-01 00:00:00

  • An environmental intervention to reduce dietary fat in school lunches.

    abstract:OBJECTIVE:To determine whether making a low-fat entree available as one of two choices in an elementary school lunch program would reduce the fat content of meals selected by children. DESIGN:In this before-after trial, students had a daily choice between two entrees, one of which was sometimes low-fat. For 93% of sch...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Whitaker RC,Wright JA,Finch AJ,Psaty BM

    更新日期:1993-06-01 00:00:00

  • Executive functioning of 4 children with hyperphenylalaninemia from childhood to adolescence.

    abstract::Hyperphenylalaninemia is a variant of phenylketonuria, and debate remains as to what, if any, active management of this condition is required to preserve cognitive function and psychological well-being. This study is the first to examine longitudinally the executive function (EF) in adolescents with hyperphenylalanine...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-4200

    authors: Sharman R,Sullivan KA,Jones T,Young RM,McGill J

    更新日期:2015-04-01 00:00:00

  • Please Test My Child for a Cancer Gene, but Don't Tell Her.

    abstract::A 38-year-old woman is diagnosed with Li-Fraumeni syndrome, an autosomal dominant genetic condition that predisposes to a variety of cancers. The woman has an 11-year-old daughter. The geneticist recommends that the child be tested for the Li-Fraumeni genetic variant. The mother is concerned about the impact of testin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2238

    authors: Bester J,Sabatello M,van Karnebeek CDM,Lantos JD

    更新日期:2018-04-01 00:00:00

  • Beliefs about the health effects of "thirdhand" smoke and home smoking bans.

    abstract:OBJECTIVE:There is no safe level of exposure to tobacco smoke. Thirdhand smoke is residual tobacco smoke contamination that remains after the cigarette is extinguished. Children are uniquely susceptible to thirdhand smoke exposure. The objective of this study was to assess health beliefs of adults regarding thirdhand s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2184

    authors: Winickoff JP,Friebely J,Tanski SE,Sherrod C,Matt GE,Hovell MF,McMillen RC

    更新日期:2009-01-01 00:00:00

  • Use and yield of chest computed tomography in the diagnostic evaluation of pediatric lung disease.

    abstract:OBJECTIVE:Computed tomography is commonly used in the diagnosis of pediatric lung disease. Although the radiation is not negligible, the yield has never been studied. METHODS:Clinical and imaging data were collected for all children who underwent chest computed tomography, as part of the diagnostic process. Cases were...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2694

    authors: Schneebaum N,Blau H,Soferman R,Mussaffi H,Ben-Sira L,Schwarz M,Sivan Y

    更新日期:2009-08-01 00:00:00

  • Prenatal Exposure to Acetaminophen and Risk of ADHD.

    abstract:OBJECTIVES:To estimate the association between maternal use of acetaminophen during pregnancy and of paternal use before pregnancy with attention-deficit/hyperactivity disorder (ADHD) in offspring while adjusting for familial risk for ADHD and indications of acetaminophen use. METHODS:Diagnoses were obtained from the ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-3840

    authors: Ystrom E,Gustavson K,Brandlistuen RE,Knudsen GP,Magnus P,Susser E,Davey Smith G,Stoltenberg C,Surén P,Håberg SE,Hornig M,Lipkin WI,Nordeng H,Reichborn-Kjennerud T

    更新日期:2017-11-01 00:00:00

  • Etiology of childhood bacteremia and timely antibiotics administration in the emergency department.

    abstract:BACKGROUND:Bacteremia is now an uncommon presentation to the children's emergency department (ED) but is associated with significant morbidity and mortality. Its evolving etiology may affect the ability of clinicians to initiate timely, appropriate antimicrobial therapy. METHODS:A retrospective time series analysis of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-2061

    authors: Irwin AD,Drew RJ,Marshall P,Nguyen K,Hoyle E,Macfarlane KA,Wong HF,Mekonnen E,Hicks M,Steele T,Gerrard C,Hardiman F,McNamara PS,Diggle PJ,Carrol ED

    更新日期:2015-04-01 00:00:00

  • Difficult Family Relationships, Residential Greenspace, and Childhood Asthma.

    abstract:BACKGROUND AND OBJECTIVES:Both the social environment and the physical environment are increasingly recognized as important to childhood diseases such as asthma. This study tested a novel hypothesis: that living in areas high in greenspace may help buffer the effects of difficult family relationships for children with ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-3056

    authors: Chen E,Miller GE,Shalowitz MU,Story RE,Levine CS,Hayen R,Sbihi H,Brauer M

    更新日期:2017-04-01 00:00:00

  • Clostridium difficile in normal infants and sudden infant death syndrome: an association with infant formula feeding.

    abstract::Large numbers Clostridium difficile were found in the stools of two victims of sudden infant death syndrome (SIDS). This prompted a study of normal infants in the SIDS age group. Thirty-two infants were studied, using two selective culture techniques and two assays for bacterial products. Thirteen of the normal infant...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Cooperstock MS,Steffen E,Yolken R,Onderdonk A

    更新日期:1982-07-01 00:00:00

  • Treatment of apnea of prematurity with aminophylline.

    abstract::The effectiveness of aminophylline in the treatment of apnea of prematurity was evaluated in 13 premature infants (mean birthweight, 1.13 kg; mean gestational age, 29 weeks). Apnea was recorded by direct observation in combination with impedance monitoring. Rectal suppositories of aminophylline (5 mg) were given at si...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bednarek FJ,Roloff DW

    更新日期:1976-09-01 00:00:00

  • Prevalence of scalp scaling in prepubertal children.

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    更新日期:2005-01-01 00:00:00