Heat shock transcription factor 1 promotes the proliferation, migration and invasion of osteosarcoma cells.

abstract：OBJECTIVE:Management of chondral defects has long been a challenge due to poor self-healing capacity of articular cartilage. Many approaches, ranging from symptomatic treatment to structural cartilage regeneration, have obtained very limited satisfactory results. Cartilage tissue engineering, which involves optimized c...

journal_title：Cell proliferation

authors： Fu N,Liao J,Lin S,Sun K,Tian T,Zhu B,Lin Y

更新日期：2016-12-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a severe health problem worldwide, and vascular calcification (VC) contributes substantially to the cardiovascular morbidity and high mortality of CKD. CKD is often accompanied by a variety of pathophysiological states, such as inflammation, oxidative stress, hyperglycaemia, hyperparath...

journal_title：Cell proliferation

authors： Zhang YX,Tang RN,Wang LT,Liu BC

更新日期：2021-01-27 00:00:00

abstract：:The human skin equivalent (HSE) is an in vitro reconstructed model that resembles skin morphologically and biochemically. The HSE is formed by overlaying a fibroblast-populated collagen matrix with a suspension of epidermal cells. Basal keratinocytes attach to the dermal equivalent via a newly formed basement membrane...

journal_title：Cell proliferation

authors： Graeter LJ,Hull BE

更新日期：1996-12-01 00:00:00

abstract：:Advances in transcriptome sequencing have revealed that the genome fraction largely encodes for thousands of non-coding RNAs. Long non-coding RNAs (lncRNAs), which are a class of non-protein-coding RNAs longer than approximately 200 nucleotides in length, are emerging as key epigenetic regulators of gene expression re...

journal_title：Cell proliferation

authors： Tang L,Liang Y,Xie H,Yang X,Zheng G

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Thyroid carcinoma (TC) represents a malignant neoplasm affecting the thyroid. Current treatment strategies include the removal of part of the thyroid; however, this approach is associated with a significant risk of developing hypothyroidism. In order to adequately understand the expression profiles of TNRC6C...

journal_title：Cell proliferation

authors： Yang LX,Wu J,Guo ML,Zhang Y,Ma SG

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Steroid-induced osteonecrosis of the femoral head (ONFH) is a common orthopaedic disease of which early detection remains clinically challenging. Accumulating evidences indicated that circulating microRNAs (miRNAs) plays vital roles in the development of several bone diseases. However, the association betwee...

journal_title：Cell proliferation

authors： Li Z,Jiang C,Li X,Wu WKK,Chen X,Zhu S,Ye C,Chan MTV,Qian W

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Small aromatic compounds like flavonoids can intercalate with DNA molecules bringing about conformational changes leading to reduced replication and transcription. Here, we have examined one dietary flavonoid, quercetin (found in many fruit and vegetables), for possible anti-cancer effects, on HeLa cells ori...

journal_title：Cell proliferation

authors： Bishayee K,Ghosh S,Mukherjee A,Sadhukhan R,Mondal J,Khuda-Bukhsh AR

更新日期：2013-04-01 00:00:00

abstract：:In vitro cultured Ehrlich ascites tumour (EAT) cells were used because of the ease of their manipulation under different levels of hypoxia. They were used to clarify further the complex mechanism of oxygen-dependent cell proliferation. On reducing the oxygen concentration from 20% to lower levels (1-7%) an increase in...

journal_title：Cell proliferation

authors： Löffler M

更新日期：1992-05-01 00:00:00

abstract：:Several methods to synchronize cultured cells in the cell cycle are based on temporary inhibition of DNA replication. Previously it has been reported that cells synchronized this way exhibited significant growth imbalance and unscheduled expression of cyclins A and B1. We have now observed that HL-60 cells exposed to ...

journal_title：Cell proliferation

authors： Kurose A,Tanaka T,Huang X,Traganos F,Darzynkiewicz Z

更新日期：2006-06-01 00:00:00

abstract：:L-type voltage-gated calcium ion channels (L-VGCCs) have been demonstrated to be the mediator of several significant intracellular activities in excitable cells, such as neurons, chromaffin cells and myocytes. Recently, an increasing number of studies have investigated the function of L-VGCCs in non-excitable cells, p...

journal_title：Cell proliferation

authors： Tan YZ,Fei DD,He XN,Dai JM,Xu RC,Xu XY,Wu JJ,Li B

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:Induced pluripotent stem cell (iPSC)-derived cardiomyocytes are a promising source of cells for regenerative heart disease therapies, but progress towards their use has been limited by their low differentiation efficiency and high cellular heterogeneity. Previous studies have demonstrated expression of adren...

journal_title：Cell proliferation

authors： Li XL,Zeng D,Chen Y,Ding L,Li WJ,Wei T,Ou DB,Yan S,Wang B,Zheng QS

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVES:Oral cancer represents one of the most common malignancies in humans. Its prognosis is still poor, despite the most recent improvements in therapies. An increasing attention is placed on the role of programmed death ligand 1 (PD-L1) in the tumour immunity and its potential function as a marker for tumour pro...

journal_title：Cell proliferation

authors： Troiano G,Caponio VCA,Zhurakivska K,Arena C,Pannone G,Mascitti M,Santarelli A,Lo Muzio L

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:Long non-coding RNAs have identified to involve into the tumour cell proliferation, apoptosis and metastasis. We previously found that up-regulated LncRNA-SNHG7 (SNHG7) positively correlated to the Fas apoptosis inhibitory molecule 2 (FAIM2) in lung cancer cells with unclear mechanism. METHODS:Non-small cel...

journal_title：Cell proliferation

authors： She K,Yan H,Huang J,Zhou H,He J

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:To assess the expression, prognostic value, and functionality of T-lymphokine-activated killer (T-LAK) cell-originated protein kinase (TOPK) in chordoma pathogenesis. MATERIALS AND METHODS:TOPK expression in chordoma was assessed via immunohistochemical staining of a tissue microarray (TMA) and correlated w...

journal_title：Cell proliferation

authors： Thanindratarn P,Dean DC,Nelson SD,Hornicek FJ,Duan Z

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:Ubiquitin specific protease 32 (USP32) is a highly conserved but uncharacterized gene, which has been reported to be associated with growth of breast cancer cells. However, the role of USP32 in human small cell lung cancer (SCLC) has not been uncovered. The aim of this study was to investigate and evaluate t...

journal_title：Cell proliferation

authors： Hu W,Wei H,Li K,Li P,Lin J,Feng R

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To determine the inhibitory effect and mechanism of Notch signalling on adipogenesis of mouse adipose-derived stem cells (mASCs). MATERIALS AND METHODS:Varied concentrations of N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butylester (DAPT) were added to mASCs 3 days before adipogenic induction w...

journal_title：Cell proliferation

authors： Huang Y,Yang X,Wu Y,Jing W,Cai X,Tang W,Liu L,Liu Y,Grottkau BE,Lin Y

更新日期：2010-04-01 00:00:00

abstract：:Electromagnetic ultra-wideband pulses (UWB) or nanopulses, are generated by a wide range of electronic devices used in communications and radar technology. However, the specific effects of nanopulse exposure on cell growth and function have not been extensively investigated. Here, studies have been conducted to determ...

journal_title：Cell proliferation

authors： Sylvester PW,Shah SJ,Haynie DT,Briski KP

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:Limbal stem cells (LSC) are self-renewing, highly proliferative cells in vitro, which express a set of specific markers and in vivo have the capacity to reconstruct the entire corneal epithelium in cases of ocular surface injury. Currently, LSC transplantation is a commonly used procedure in patients with ei...

journal_title：Cell proliferation

authors： Monteiro BG,Serafim RC,Melo GB,Silva MC,Lizier NF,Maranduba CM,Smith RL,Kerkis A,Cerruti H,Gomes JA,Kerkis I

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:This study focuses on experimental analysis and corresponding mathematical simulation of in vitro HUVECs (human umbilical vein endothelial cells) proliferation in the presence of various types of drugs. MATERIALS AND METHODS:HUVECs, once seeded in Petri dishes, were expanded to confluence. Temporal profiles...

journal_title：Cell proliferation

authors： Mancuso L,Scanu M,Pisu M,Concas A,Cao G

更新日期：2010-12-01 00:00:00

abstract：:Proliferation and multidrug resistance status are key predictors of therapeutic outcome in acute myeloid leukaemia (AML). Anthracyclines such as daunorubicin (DNR) are typically used to treat AML and can induce drug resistance. The goal of the studies described here was to select a combination of fluorescent probes th...

journal_title：Cell proliferation

authors： Boutonnat J,Barbier M,Muirhead K,Mousseau M,Ronot X,Seigneurin D

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVES:The bone tissue engineering primarily focuses on three-dimensional co-culture systems, which physical and biological properties resemble the cell matrix of actual tissues. The complex dialogue between bone-forming and endothelial cells (ECs) in a tissue-engineered construct will directly regulate angiogenesi...

journal_title：Cell proliferation

authors： Li L,Li J,Zou Q,Zuo Y,Cai B,Li Y

更新日期：2019-09-01 00:00:00

abstract：:The epithelium of the oral cavity and small intestine of the gastrointestinal tract have a high rate of cell renewal and as such, are sensitive to cytotoxic therapies that kill rapidly dividing cells. Mucositis is a complication of cancer therapy where impairment of the regenerative capacity of the epithelium leads to...

journal_title：Cell proliferation

authors： Farrell CL,Rex KL,Chen JN,Bready JV,DiPalma CR,Kaufman SA,Rattan A,Scully S,Lacey DL

更新日期：2002-08-01 00:00:00

abstract：:The R- cell line is a 3T3-like cell line originating from mouse embryos with a homozygous disruption of the type 1 insulin-like growth factor receptor (IGF-IR) genes. Although R- cells cannot grow at all in serum-free medium (SFM) supplemented by several known growth factors, either singly or in combination, they are ...

journal_title：Cell proliferation

authors： Xu SQ,Sell C,DuBois GC,Baserga R

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the rapid repair potential of adipose-derived stem cells (ADSCs) co-overexpressing VEGF and GDNF on bilateral cavernous nerve injury (BCNI) in rat models. Progressive fibrosis of the penis that occurs shortly after BCNI is a key cause of clinical treatment difficulty of erectile dysfunction (ED)....

journal_title：Cell proliferation

authors： Yang W,Chen Z,Ma X,Ouyang X,Fang J,Wei H

更新日期：2020-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a primary liver malignancy with a high global prevalence and a dismal prognosis. Studies are urgently needed to examine the molecular pathogenesis and biological characteristics of HCC. Chromatin remodelling, an integral component of the DNA damage response, protects against DNA damag...

journal_title：Cell proliferation

authors： Hu B,Lin JZ,Yang XB,Sang XT

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Hyperinsulinemia is a risk factor for pancreatic cancer, but the function of insulin in carcinogenesis is unclear, so this study aimed to elucidate the carcinogenic effects of insulin and the synergistic effect with the KRAS mutation in the early stage of pancreatic cancer. MATERIALS AND METHODS:A pair of i...

journal_title：Cell proliferation

authors： Wang G,Yin L,Peng Y,Gao Y,Gao H,Zhang J,Lv N,Miao Y,Lu Z

更新日期：2019-05-01 00:00:00

abstract：:The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This review will focus on these mechanisms, i.e. regulation of cyclin-dependent kinases (CDK) by cyclins, CDK inhibitors and phosphorylating events. The quality checkpoints activated after DNA damage are also discussed. The complexity ...

journal_title：Cell proliferation

authors： Vermeulen K,Van Bockstaele DR,Berneman ZN

更新日期：2003-06-01 00:00:00

abstract：:A model of intestinal crypt organization is suggested based on the assumption that stem cells have a finite replicative life span. The model assumes the existence in a crypt of a quiescent ('deep') stem cell and a few more actively cycling ('proximate') stem cells. Monte Carlo computer simulation of published intestin...

journal_title：Cell proliferation

authors： Lobachevsky PN,Radford IR

更新日期：2006-10-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non-coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in eukaryotic cells. ...

journal_title：Cell proliferation

authors： Mei J,Hao L,Wang H,Xu R,Liu Y,Zhu Y,Liu C

更新日期：2020-05-01 00:00:00

abstract：:The proliferation rate of mammalian cells is regulated normally in the G1 phase of the cell cycle. During this phase, it is convenient to assign positive and negative roles to the molecular programs that regulate the duration of G1 and the phase transition from G1 to S phase. Density-dependent inhibition of cellular p...

journal_title：Cell proliferation

authors： DiSalvo CV,Zhang D,Jacobberger JW

更新日期：1995-09-01 00:00:00