Long non-coding RNAs in cutaneous biology and proliferative skin diseases: Advances and perspectives.

abstract：:The signal transducers and activators of transcription--STAT5A and STAT5B--take part in the regulation of many essential physiopathological processes. They influence the cell cycle, apoptosis and the proliferation of different types of cell lines. The STAT5 proteins are induced in response to multiple haematopoietic c...

journal_title：Cell proliferation

authors： Baśkiewicz-Masiuk M,Masiuk M,Machaliński B

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVES:Glucagon-like peptide 2 (GLP2) is involved in the regulation of energy absorption and metabolism. Despite the importance of the GLP2 signalling mechanisms on osteoclast, little has been studied on how GLP2 works during osteoclastogenesis. MATERIALS AND METHODS:RAW264.7 cells were infected with rLV-Green-GLP...

journal_title：Cell proliferation

authors： Lu Y,Lu D,Hu Y

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Generally, the secretory forms of FGF are known to regulate cell proliferation, differentiation and morphogenesis by binding to the extracellular domain of cell surface receptors. Intracellular FGFs (FGF11-14) are expressed principally in the nervous system. FGF13 is a microtubule-stabilizing protein that re...

journal_title：Cell proliferation

authors： Lu H,Shi X,Wu G,Zhu J,Song C,Zhang Q,Yang G

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Curcumin (capable of inhibiting angiogenic growth of human umbilical vein endothelial cells [HUVECs]), can be employed in vitro as a model of pathogenesis of corneal neovascularization (CRNV). The aim of this study was to explore regulatory mechanisms of microRNA (miR) levels after curcumin treatment. MATERI...

journal_title：Cell proliferation

authors： Bai Y,Wang W,Sun G,Zhang M,Dong J

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:This study aims to explore the roles of N-myc and caspase-8 in TRAIL-resistant IMR-32 cells which exhibit MYCN oncogene amplification and lack caspase-8 expression. MATERIALS AND METHODS:We established N-myc-downregulated IMR-32 cells using shRNA lentiviral particles targeting N-myc and examined the effect ...

journal_title：Cell proliferation

authors： Lee MW,Kim DS,Kim HR,Park HJ,Lee JW,Sung KW,Koo HH,Yoo KH

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Vascular disorders are associated with phenotypical switching of vascular smooth muscle cells (VSMCs). We investigated the effect of bone morphogenetic protein (BMP)-2 in controlling VSMC phenotype and vascular disorder progression. Lysine (K)-specific demethylase 1A (KDM1A) has been identified to target BMP...

journal_title：Cell proliferation

authors： Zhang X,Huang T,Zhai H,Peng W,Zhou Y,Li Q,Yang H

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Somatic stem cells can be obtained from a variety of adult human tissues. However, it was not clear whether human parathyroid glands, which secrete parathyroid hormones and are essential in maintaining homeostasis levels of calcium ions in the circulation, contained stem cells. We aimed to investigate the po...

journal_title：Cell proliferation

authors： Shih YR,Kuo TK,Yang AH,Lee OK,Lee CH

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:In this study, we generated an Rbm14 knockout mouse model to explore its functions during early mouse embryogenesis. MATERIALS AND METHODS:The Rbm14 knockout mouse model was generated by a combination of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and microinjection techniques. Th...

journal_title：Cell proliferation

authors： Li J,Wang C,Feng G,Zhang L,Chen G,Sun H,Wang J,Zhang Y,Zhou Q,Li W

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:BCL2 family proteins have been widely studied over the past decade due to their essential roles in apoptosis, oncogenesis and anti-cancer therapy. However, the similarities and differences in the spatial pattern of the BCL2 gene family within the context of chromatin have not been well characterized. We soug...

journal_title：Cell proliferation

authors： Wang J,Li S,Lin S,Fu S,Qiu L,Ding K,Liang K,Du H

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:In this study, we have investigated whether secreted factors from embryonic stem cells (ESCs) could reprogramme keratinocytes and increase their potential to be directed into alternative cell lineages. MATERIALS AND METHODS:Contact and non-contact co-cultures of skin keratinocytes and murine ESCs were used ...

journal_title：Cell proliferation

authors： Grinnell KL,Bickenbach JR

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Curcumin, a natural compound, is a potent anti-cancer agent, which inhibits cell division and/or induces cell death. It is believed that normal cells are less sensitive to curcumin than malignant cells; however, the mechanism(s) responsible for curcumin's effect on normal cells are poorly understood. The aim...

journal_title：Cell proliferation

authors： Bielak-Zmijewska A,Sikora-Polaczek M,Nieznanski K,Mosieniak G,Kolano A,Maleszewski M,Styrna J,Sikora E

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:To assess the expression, prognostic value, and functionality of T-lymphokine-activated killer (T-LAK) cell-originated protein kinase (TOPK) in chordoma pathogenesis. MATERIALS AND METHODS:TOPK expression in chordoma was assessed via immunohistochemical staining of a tissue microarray (TMA) and correlated w...

journal_title：Cell proliferation

authors： Thanindratarn P,Dean DC,Nelson SD,Hornicek FJ,Duan Z

更新日期：2020-10-01 00:00:00

abstract：:The human skin equivalent (HSE) is an in vitro reconstructed model that resembles skin morphologically and biochemically. The HSE is formed by overlaying a fibroblast-populated collagen matrix with a suspension of epidermal cells. Basal keratinocytes attach to the dermal equivalent via a newly formed basement membrane...

journal_title：Cell proliferation

authors： Graeter LJ,Hull BE

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVES:Oestrogen is known to inhibit osteoclastogenesis, and numerous studies have identified it as an autophagic activator. To date, the role of oestrogen in the autophagy of osteoclast precursors (OCPs) during osteoclastogenesis remains unclear. This study aimed to determine the effect of autophagy regulated by t...

journal_title：Cell proliferation

authors： Cheng L,Zhu Y,Ke D,Xie D

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:We have evaluated the physiological roles of transforming growth factor-beta1 (TGF-beta1) on differentiation, migration, proliferation and anti-apoptosis characteristics of cultured spinal cord-derived neural progenitor cells. METHODS:We have used neural progenitor cells that had been isolated and cultured ...

journal_title：Cell proliferation

authors： Park SM,Jung JS,Jang MS,Kang KS,Kang SK

更新日期：2008-04-01 00:00:00

abstract：:Telomere length plays an important role in regulating the proliferative capacity of cells, and serves as a marker for cell cycle history and also for their remaining replicative potential. Mesenchymal stromal cells (MSC) are known to be a significant cell source for therapeutic intervention and tissue engineering. To ...

journal_title：Cell proliferation

authors： Yanada S,Ochi M,Kojima K,Sharman P,Yasunaga Y,Hiyama E

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:High mobility group protein2 (HMGA2) and epithelial-to-mesenchymal transition are both related to progress of bladder cancer, however, the relationship between HMGA2, E-cadherin and vimentin in bladder cancer is not yet known. Thus, this study has examined expression of HMGA2, E-cadherin and vimentin in blad...

journal_title：Cell proliferation

authors： Ding X,Wang Y,Ma X,Guo H,Yan X,Chi Q,Li J,Hou Y,Wang C

更新日期：2014-04-01 00:00:00

abstract：:Extracellular vesicles (EVs), a heterogeneous group of vesicles differing in size and shape, cargo content and function, are membrane-bound and nano-sized vesicles that could be released by nearly all variations of cells. EVs have gained considerable attention in the past decades for their functions in modulating inte...

journal_title：Cell proliferation

authors： Wu Z,Zhang Z,Xia W,Cai J,Li Y,Wu S

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:MicroRNAs (miRNAs) are negative regulators of gene expression that play important roles in cell processes such as proliferation, development and differentiation. Recently, it has been reported that miRNAs are related to development of carcinogenesis. The aim of this study was to identify miRNAs associated wit...

journal_title：Cell proliferation

authors： Lee JE,Hong EJ,Nam HY,Kim JW,Han BG,Jeon JP

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:Many flow-cytometric cell characterization methods require costly markers and colour reagents. We present here a novel device for cell discrimination based on impedance measurement of electrical cell properties in a microfluidic chip, without the need of extensive sample preparation steps and the requirement...

journal_title：Cell proliferation

authors： Schade-Kampmann G,Huwiler A,Hebeisen M,Hessler T,Di Berardino M

更新日期：2008-10-01 00:00:00

abstract：:The microenvironmental changes in the bone marrow, spleen and liver during progression of the transplantable promyelocytic leukaemia in the Brown Norwegian rat (BNML) have been studied. We used flow cytometry to estimate cellular hypoxia and proliferation based on in vivo pulse-labelling with a mixture of 2-nitroimida...

journal_title：Cell proliferation

authors： Jensen PO,Mortensen BT,Hodgkiss RJ,Iversen PO,Christensen IJ,Helledie N,Larsen JK

更新日期：2000-12-01 00:00:00

abstract：:A mathematical model for the cell cycle is proposed that incorporates the known biochemical reactions involving both cyclin A and cyclin B, the interactions of these cyclins with cdc2 and cdk2, and the controlling effects of cdc25 and weel. The model also postulates the existence of an as yet unknown phosphatase invol...

journal_title：Cell proliferation

authors： Obeyesekere MN,Tucker SL,Zimmerman SO

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVES:Articular cartilage plays a vital role in bearing and buffering. Injured cartilage and subchondral bone repair is a crucial challenge in cartilage tissue engineering due to the peculiar structure of osteochondral unit and the requirement of osteogenic/chondrogenic bi-directional differentiation. Based on the...

journal_title：Cell proliferation

authors： Shang L,Ma B,Wang F,Li J,Shen S,Li X,Liu H,Ge S

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:During human pregnancy, the endothelial cells of the uterine spiral arteries (SPA) are extensively replaced by a subtype of placental trophoblasts, endovascular extravillous trophoblasts (enEVTs), thus establishing a placental-maternal circulation. On this pathway, foetus-derived placental villi and enEVTs b...

journal_title：Cell proliferation

authors： Ma Y,Yang Q,Fan M,Zhang L,Gu Y,Jia W,Li Z,Wang F,Li YX,Wang J,Li R,Shao X,Wang YL

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:To understand if there exists a functional interaction between arsenic trioxide and paclitaxel in vitro. MATERIALS AND METHODS:HeLa and HCT116 (rho53(+/+) and rho53(-/-)) cells were treated with As2O3 and/or paclitaxel for various times. Treated cells were collected for analyses using a combination of flow ...

journal_title：Cell proliferation

authors： Duan Q,Komissarova E,Dai W

更新日期：2009-06-01 00:00:00

abstract：:The CD133 glycoprotein is a controversial cancer stem cell marker in the field of neuro-oncology, based largely on the now considerable experimental evidence for the existence of both CD133+ve and CD133-ve populations as tumour-initiating cells. It is thought that decreasing oxygen tension enhances the complex regulat...

journal_title：Cell proliferation

authors： Donovan LK,Pilkington GJ

更新日期：2012-12-01 00:00:00

abstract：:Nerous system diseases, both central and peripheral, bring an incredible burden onto patients and enormously reduce their quality of life. Currently, there are still no effective treatments to repair nerve lesions that do not have side effects. Stem cell-based therapies, especially those using dental stem cells, bring...

journal_title：Cell proliferation

authors： Wang D,Wang Y,Tian W,Pan J

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Accumulating evidence demonstrated that the long noncoding RNA (lncRNA) HOTAIR (Hox transcript antisense intergenic RNA) plays key role in renal cell carcinoma (RCC) malignancy, while microRNA-124 (miR-124) is a tumour suppressor in RCC. The aim of this work was to assess the biological function of HOTAIR an...

journal_title：Cell proliferation

authors： Pan Y,Wu Y,Hu J,Shan Y,Ma J,Ma H,Qi X,Jia L

更新日期：2018-12-01 00:00:00

abstract：:RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. To study the possibility of a novel system of cell ablation mediated by RAIDD, a preadipocyte cell line (3T3L1) was stably transfected with a plasmid containi...

journal_title：Cell proliferation

authors： Felmer R,Horvat S,Clinton M,Clark AJ

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:The aim of the current study was to investigate whether nicotine treatment would induce the proliferation of isolated rat primary pancreatic acinar cells in culture by activating mitogen-activated protein kinase (MAPK) signalling and exocrine secretion. MATERIALS AND METHODS:A nicotine dose- and time-respon...

journal_title：Cell proliferation

authors： Chowdhury P,Bose C,Udupa KB

更新日期：2007-02-01 00:00:00