Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation.

abstract：OBJECTIVES:Small aromatic compounds like flavonoids can intercalate with DNA molecules bringing about conformational changes leading to reduced replication and transcription. Here, we have examined one dietary flavonoid, quercetin (found in many fruit and vegetables), for possible anti-cancer effects, on HeLa cells ori...

journal_title：Cell proliferation

authors： Bishayee K,Ghosh S,Mukherjee A,Sadhukhan R,Mondal J,Khuda-Bukhsh AR

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:miRNAs play crucial roles in human tumourigenesis. This study was performed to measure expression and function of miR-762 in breast cancer. MATERIALS AND METHODS:Expression of miR-762 in breast tissues and cell lines (SK-BR-3, DA-MB-435s, MCF-7 and MDA-MB-231, HBL-100) was measured by using real-time RT-PCR...

journal_title：Cell proliferation

authors： Li Y,Huang R,Wang L,Hao J,Zhang Q,Ling R,Yun J

更新日期：2015-12-01 00:00:00

abstract：:A model of intestinal crypt organization is suggested based on the assumption that stem cells have a finite replicative life span. The model assumes the existence in a crypt of a quiescent ('deep') stem cell and a few more actively cycling ('proximate') stem cells. Monte Carlo computer simulation of published intestin...

journal_title：Cell proliferation

authors： Lobachevsky PN,Radford IR

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:Restoring a functional beta-cell mass is a fundamental goal in treating diabetes. A complex signalling pathway network coordinates the regulation of beta-cell proliferation, although a role for ERK5 in this network has not been reported. This question was addressed in this study. MATERIALS AND METHODS:We st...

journal_title：Cell proliferation

authors： Chen C,Wu S,Lin X,Wu D,Fischbach S,Xiao X

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Postflight orthostatic intolerance has been regarded as a major adverse effect after microgravity exposure, in which cerebrovascular adaptation plays a critical role. Our previous finding suggested that dedifferentiation of vascular smooth muscle cells (VSMCs) might be one of the key contributors to cerebrov...

journal_title：Cell proliferation

authors： Zhang B,Chen L,Bai YG,Song JB,Cheng JH,Ma HZ,Ma J,Xie MJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:We previously reported that Golgi phosphoprotein 3 (GOLPH3) promotes glioma progression by inhibiting EGFR endocytosis and degradation, leading to EGFR accumulation and PI3K-AKT pathway over-activation. In the current study, we examine whether GOLPH3 affects the response of glioma cells to gefitinib, an EGFR...

journal_title：Cell proliferation

authors： Wang X,Wang Z,Zhang Y,Wang Y,Zhang H,Xie S,Xie P,Yu R,Zhou X

更新日期：2019-07-01 00:00:00

abstract：:Electromagnetic ultra-wideband pulses (UWB) or nanopulses, are generated by a wide range of electronic devices used in communications and radar technology. However, the specific effects of nanopulse exposure on cell growth and function have not been extensively investigated. Here, studies have been conducted to determ...

journal_title：Cell proliferation

authors： Sylvester PW,Shah SJ,Haynie DT,Briski KP

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:Ubiquitin specific protease 32 (USP32) is a highly conserved but uncharacterized gene, which has been reported to be associated with growth of breast cancer cells. However, the role of USP32 in human small cell lung cancer (SCLC) has not been uncovered. The aim of this study was to investigate and evaluate t...

journal_title：Cell proliferation

authors： Hu W,Wei H,Li K,Li P,Lin J,Feng R

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:To understand if there exists a functional interaction between arsenic trioxide and paclitaxel in vitro. MATERIALS AND METHODS:HeLa and HCT116 (rho53(+/+) and rho53(-/-)) cells were treated with As2O3 and/or paclitaxel for various times. Treated cells were collected for analyses using a combination of flow ...

journal_title：Cell proliferation

authors： Duan Q,Komissarova E,Dai W

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:Curcumin, a natural compound, is a potent anti-cancer agent, which inhibits cell division and/or induces cell death. It is believed that normal cells are less sensitive to curcumin than malignant cells; however, the mechanism(s) responsible for curcumin's effect on normal cells are poorly understood. The aim...

journal_title：Cell proliferation

authors： Bielak-Zmijewska A,Sikora-Polaczek M,Nieznanski K,Mosieniak G,Kolano A,Maleszewski M,Styrna J,Sikora E

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:Advanced head and neck carcinomas (HNCs) are aggressive tumours, mainly due to hypoxia and a cancer stem cell (CSC) subpopulation. The aim of this study was to simulate tumour growth and behaviour during radiotherapy of three HNC groups (governed by different growth kinetics, hypoxia levels and CSC division ...

journal_title：Cell proliferation

authors： Marcu LG,Marcu D,Filip SM

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Osteosarcoma is the most commonly diagnosed primary malignancy of bone and its overall survival rate is still very low. The molecular mechanisms underlying the progression of osteosarcoma have not been clearly illuminated. Heat shock transcription factor 1 (HSF1) is a key regulator of the heat shock response...

journal_title：Cell proliferation

authors： Zhou Z,Li Y,Jia Q,Wang Z,Wang X,Hu J,Xiao J

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:BCL2 family proteins have been widely studied over the past decade due to their essential roles in apoptosis, oncogenesis and anti-cancer therapy. However, the similarities and differences in the spatial pattern of the BCL2 gene family within the context of chromatin have not been well characterized. We soug...

journal_title：Cell proliferation

authors： Wang J,Li S,Lin S,Fu S,Qiu L,Ding K,Liang K,Du H

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:SAV1 is a human homologue of Salvador that contains two protein-protein interaction modules known as WW domains and acts as a scaffolding protein. SAV1 participates in the development of diverse types of cancer. We aimed to investigate the role of SAV1 in human colorectal cancer. MATERIALS AND METHODS:Human...

journal_title：Cell proliferation

authors： Jiang J,Chang W,Fu Y,Gao Y,Zhao C,Zhang X,Zhang S

更新日期：2017-08-01 00:00:00

abstract：:RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. To study the possibility of a novel system of cell ablation mediated by RAIDD, a preadipocyte cell line (3T3L1) was stably transfected with a plasmid containi...

journal_title：Cell proliferation

authors： Felmer R,Horvat S,Clinton M,Clark AJ

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:This study has aimed to study different culture systems that might stimulate an increase in cell proliferation of normal and osteoarthritis chondrocytes from articular cartilage in rat model. MATERIAL AND METHODS:Three culture systems using chondrocytes embedded in alginate beads were tested: chondrocytes cu...

journal_title：Cell proliferation

authors： Gomez-Camarillo MA,Almonte-Becerril M,Vasquez Tort M,Tapia-Ramirez J,Kouri Flores JB

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVES:Mitophagy is considered to be a key mechanism in the pathogenesis of intestinal ischaemic reperfusion (IR) injury. NOD-like receptor X1 (NLRX1) is located in the mitochondria and is highly expressed in the intestine, and is known to modulate ROS production, mitochondrial damage, autophagy and apoptosis. Howe...

journal_title：Cell proliferation

authors： Li S,Zhou Y,Gu X,Zhang X,Jia Z

更新日期：2021-01-11 00:00:00

abstract：OBJECTIVES:Whole-tooth regeneration for tooth loss has long been a goal of dentistry. There is also an increasing demand to carry out pre-clinical in vitro and in vivo research methods in large animal model similar to human. The miniature pig has proven to be an alternative as a large mammal model owing to its many sim...

journal_title：Cell proliferation

authors： Wang F,Wu Z,Fan Z,Wu T,Wang J,Zhang C,Wang S

更新日期：2018-08-01 00:00:00

abstract：:Intra-erythrocytic Plasmodium species can be stained with the DNA binding dye, Hoechst 33342, and the distribution of DNA content determined for parasite populations by flow cytometric measurement of fluorescence. Analysis of this distribution will determine the parasitaemia (percentage of erythrocytes infected), and ...

journal_title：Cell proliferation

authors： Jacobberger JW,Horan PK,Hare JD

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVES:The main purpose of current study was to explore the effects of tetrahedral DNA nanostructures (TDNs) on neuroectodermal (NE-4C) stem cells migration and unveil the potential mechanisms. MATERIALS AND METHODS:The successfully self-assembled TDNs were also determined by dynamic light scattering (DLS). A bidi...

journal_title：Cell proliferation

authors： Ma W,Xie X,Shao X,Zhang Y,Mao C,Zhan Y,Zhao D,Liu M,Li Q,Lin Y

更新日期：2018-12-01 00:00:00

abstract：:We previously found that the stable overexpression of oestrogen receptor-alpha in the human endothelial cell line ECV304* inhibits its growth in vitro, and that this inhibition is possibly mediated through a down-regulation of the vasoactive agents endothelin-1 and vascular endothelial growth factor. Here we show an i...

journal_title：Cell proliferation

authors： Ali SH,O'Donnell AL,Balu D,Pohl MB,Seyler MJ,Mohamed S,Mousa S,Dandona P

更新日期：2001-08-01 00:00:00

abstract：:The CD133 glycoprotein is a controversial cancer stem cell marker in the field of neuro-oncology, based largely on the now considerable experimental evidence for the existence of both CD133+ve and CD133-ve populations as tumour-initiating cells. It is thought that decreasing oxygen tension enhances the complex regulat...

journal_title：Cell proliferation

authors： Donovan LK,Pilkington GJ

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the role of insulin-like growth factor-1 (IGF-1) and crosstalk between endothelial cells (ECs) and adipose-derived stem cells (ASCs) in the process of angiogenesis. METHODS:A three-dimensional collagen gel used to culture mouse ASCs and mouse ECs in vitro was establi...

journal_title：Cell proliferation

authors： Lin S,Zhang Q,Shao X,Zhang T,Xue C,Shi S,Zhao D,Lin Y

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Accumulating evidence demonstrated that the long noncoding RNA (lncRNA) HOTAIR (Hox transcript antisense intergenic RNA) plays key role in renal cell carcinoma (RCC) malignancy, while microRNA-124 (miR-124) is a tumour suppressor in RCC. The aim of this work was to assess the biological function of HOTAIR an...

journal_title：Cell proliferation

authors： Pan Y,Wu Y,Hu J,Shan Y,Ma J,Ma H,Qi X,Jia L

更新日期：2018-12-01 00:00:00

abstract：:Studies on growth regulation in vitro to a large extent rely on comparison of growth curves. However, these do not discriminate between the relative contributions of the mitotic rate and the apoptotic rate to the net growth rate. In the present study, differential effects of 17beta-oestradiol (E2, 10(-8) M) and/or tam...

journal_title：Cell proliferation

authors： Budtz PE

更新日期：1999-10-01 00:00:00

abstract：:The human skin equivalent (HSE) is an in vitro reconstructed model that resembles skin morphologically and biochemically. The HSE is formed by overlaying a fibroblast-populated collagen matrix with a suspension of epidermal cells. Basal keratinocytes attach to the dermal equivalent via a newly formed basement membrane...

journal_title：Cell proliferation

authors： Graeter LJ,Hull BE

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVES:Dental follicle cells (DFCs) provide the origin of periodontal tissues, and Runx2 is essential for bone formation and tooth development. In this study, pluripotency of DFCs was evaluated and effects of Runx2 on them were investigated. MATERIALS AND METHODS:The DFCs were induced to differentiate towards oste...

journal_title：Cell proliferation

authors： Pan K,Sun Q,Zhang J,Ge S,Li S,Zhao Y,Yang P

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Pre-eclampsia is a leading cause of morbidity and mortality during pregnancy. Although the two forms of this disorder, early- (EOPE) and late-onset of pre-eclampsia (LOPE) are different, the underlying pathology remains elusive. We aim to unravel the difference and to identify novel biomarkers for EOPE and L...

journal_title：Cell proliferation

authors： Guo F,Zhang B,Yang H,Fu Y,Wang Y,Huang J,Cheng M,Li X,Shen Z,Li L,He P,Xiang AP,Wang S,Zhang H

更新日期：2020-12-17 00:00:00

abstract：OBJECTIVE:In this study, we generated an Rbm14 knockout mouse model to explore its functions during early mouse embryogenesis. MATERIALS AND METHODS:The Rbm14 knockout mouse model was generated by a combination of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and microinjection techniques. Th...

journal_title：Cell proliferation

authors： Li J,Wang C,Feng G,Zhang L,Chen G,Sun H,Wang J,Zhang Y,Zhou Q,Li W

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:  The focus of this study was to determine the dedicator of cytokinesis 2 (DOCK2), extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase-1 (JNK) and Akt signals involved in CXCL13-mediated prostate cancer (PCa) cell invasion and proliferation. MATERIALS AND METHODS:  Androgen-sensitive...

journal_title：Cell proliferation

authors： El-Haibi CP,Singh R,Sharma PK,Singh S,Lillard JW Jr

更新日期：2011-08-01 00:00:00