Curcumin inhibits angiogenesis by up-regulation of microRNA-1275 and microRNA-1246: a promising therapy for treatment of corneal neovascularization.

abstract：:This study examines epithelial cell streaming and turnover in normal rat bulbar conjunctiva. Twenty seven male adult random-bred Hebrew rats weighing between 250-300 g, were injected i.p. with [3H]-thymidine. Three rats were killed at various times, thereafter from 1 h to 28 days. The enucleated eyes were fixed in for...

journal_title：Cell proliferation

authors： Zajicek G,Perry A,Pe'er J

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:To determine the inhibitory effect and mechanism of Notch signalling on adipogenesis of mouse adipose-derived stem cells (mASCs). MATERIALS AND METHODS:Varied concentrations of N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butylester (DAPT) were added to mASCs 3 days before adipogenic induction w...

journal_title：Cell proliferation

authors： Huang Y,Yang X,Wu Y,Jing W,Cai X,Tang W,Liu L,Liu Y,Grottkau BE,Lin Y

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:Restoring a functional beta-cell mass is a fundamental goal in treating diabetes. A complex signalling pathway network coordinates the regulation of beta-cell proliferation, although a role for ERK5 in this network has not been reported. This question was addressed in this study. MATERIALS AND METHODS:We st...

journal_title：Cell proliferation

authors： Chen C,Wu S,Lin X,Wu D,Fischbach S,Xiao X

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:This study is to explore the role of Notch signalling during the regeneration of rat tracheal epithelium after injury induced by 5-fluorouracil (5-FU). MATERIALS AND METHODS:We developed an ex vivo model of rat tracheal epithelial regeneration using 5-FU to induce injury. Expression levels of members of the...

journal_title：Cell proliferation

authors： Ma XB,Jia XS,Liu YL,Wang LL,Sun SL,Song N,Wang EH,Li F

更新日期：2009-02-01 00:00:00

abstract：:The epithelium of the oral cavity and small intestine of the gastrointestinal tract have a high rate of cell renewal and as such, are sensitive to cytotoxic therapies that kill rapidly dividing cells. Mucositis is a complication of cancer therapy where impairment of the regenerative capacity of the epithelium leads to...

journal_title：Cell proliferation

authors： Farrell CL,Rex KL,Chen JN,Bready JV,DiPalma CR,Kaufman SA,Rattan A,Scully S,Lacey DL

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVES:In this study, we have investigated whether secreted factors from embryonic stem cells (ESCs) could reprogramme keratinocytes and increase their potential to be directed into alternative cell lineages. MATERIALS AND METHODS:Contact and non-contact co-cultures of skin keratinocytes and murine ESCs were used ...

journal_title：Cell proliferation

authors： Grinnell KL,Bickenbach JR

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Temozolomide (TMZ) is one of the most commonly used clinical drugs for glioblastoma (GBM) treatment, but its drug sensitivity needs to be improved. Gamabufotalin (CS-6), the primary component of the traditional Chinese medicine "ChanSu," was shown to have strong anti-cancer activity. However, more efforts sh...

journal_title：Cell proliferation

authors： Lan YL,Chen C,Wang X,Lou JC,Xing JS,Zou S,Hu JL,Lyu W,Zhang B

更新日期：2020-01-01 00:00:00

abstract：:Sertoli cells (SeC) are responsible for the immunoprivileged status of the testis thanks to which allogeneic or xenogeneic engraftments can survive without pharmacological immune suppression if co-injected with SeC. This peculiar ability of SeC is dependent on secretion of a plethora of factors including maturation fa...

journal_title：Cell proliferation

authors： Chiappalupi S,Salvadori L,Luca G,Riuzzi F,Calafiore R,Donato R,Sorci G

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Thyroid carcinoma (TC) represents a malignant neoplasm affecting the thyroid. Current treatment strategies include the removal of part of the thyroid; however, this approach is associated with a significant risk of developing hypothyroidism. In order to adequately understand the expression profiles of TNRC6C...

journal_title：Cell proliferation

authors： Yang LX,Wu J,Guo ML,Zhang Y,Ma SG

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Advanced head and neck carcinomas (HNCs) are aggressive tumours, mainly due to hypoxia and a cancer stem cell (CSC) subpopulation. The aim of this study was to simulate tumour growth and behaviour during radiotherapy of three HNC groups (governed by different growth kinetics, hypoxia levels and CSC division ...

journal_title：Cell proliferation

authors： Marcu LG,Marcu D,Filip SM

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Low levels of adiponectin (APN), a biomarker of diabetes mellitus, have been implicated in the poor outcome of intracerebral haemorrhage (ICH). Herein, we aimed to demonstrate the neuroprotective effects of a blood-brain barrier-permeable APN peptide (APNp) on ICH injury in diabetic mice and explore the under...

journal_title：Cell proliferation

authors： Wu X,Luo J,Liu H,Cui W,Guo W,Zhao L,Guo H,Bai H,Guo K,Feng D,Qu Y

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Stiffness of bone tissue differs response to its physiological or pathological status, such as osteoporosis or osteosclerosis. Consequently, the function of cells residing in bone tissue including osteoblasts (OBs), osteoclasts and osteocytes will be affected. However, to the best of our knowledge, the detai...

journal_title：Cell proliferation

authors： Zhang T,Lin S,Shao X,Zhang Q,Xue C,Zhang S,Lin Y,Zhu B,Cai X

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:The bone tissue engineering primarily focuses on three-dimensional co-culture systems, which physical and biological properties resemble the cell matrix of actual tissues. The complex dialogue between bone-forming and endothelial cells (ECs) in a tissue-engineered construct will directly regulate angiogenesi...

journal_title：Cell proliferation

authors： Li L,Li J,Zou Q,Zuo Y,Cai B,Li Y

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVES:Mouse embryonic stem cell (mESC) culture contains various heterogeneous populations, which serve as excellent models to study gene regulation in early embryo development. The heterogeneity is typically defined by transcriptional activities, for example, the expression of Nanog or Rex1 mRNA. Our objectives we...

journal_title：Cell proliferation

authors： Hao J,Yang X,Zhang C,Zhang XT,Shi M,Wang SH,Mi L,Zhao YT,Cao H,Wang Y

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:We previously reported that Golgi phosphoprotein 3 (GOLPH3) promotes glioma progression by inhibiting EGFR endocytosis and degradation, leading to EGFR accumulation and PI3K-AKT pathway over-activation. In the current study, we examine whether GOLPH3 affects the response of glioma cells to gefitinib, an EGFR...

journal_title：Cell proliferation

authors： Wang X,Wang Z,Zhang Y,Wang Y,Zhang H,Xie S,Xie P,Yu R,Zhou X

更新日期：2019-07-01 00:00:00

abstract：:Cell proliferation was investigated in human tumour xenografts using bromodeoxyuridine (BrdUrd) labelling, evaluated either by flow cytometry or in tissue sections, and also using the proliferation marker Ki-67. BrdUrd labelling was found to increase when cryostat tumour sections were digested with an enzymic solution...

journal_title：Cell proliferation

authors： Parkins CS,Bush C,Price P,Steel GG

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVES:Pre-eclampsia is a leading cause of morbidity and mortality during pregnancy. Although the two forms of this disorder, early- (EOPE) and late-onset of pre-eclampsia (LOPE) are different, the underlying pathology remains elusive. We aim to unravel the difference and to identify novel biomarkers for EOPE and L...

journal_title：Cell proliferation

authors： Guo F,Zhang B,Yang H,Fu Y,Wang Y,Huang J,Cheng M,Li X,Shen Z,Li L,He P,Xiang AP,Wang S,Zhang H

更新日期：2020-12-17 00:00:00

abstract：OBJECTIVES:Enterochromaffin (EC) cells have been associated with functional gastrointestinal disorders such as IBS. Recently, we found that glial cell-derived neurotrophic factor (GDNF)-rearranged during transfection (RET) localized in EC cells in human colonic epithelia. Here, we examine the role of GDNF-RET in the pa...

journal_title：Cell proliferation

authors： Lin L,Feng B,Zhou R,Liu Y,Li L,Wang K,Yu Y,Liu C,Long X,Gu X,Li B,Wang X,Yang X,Cong Y,Zuo X,Li Y

更新日期：2020-10-01 00:00:00

abstract：:We previously found that the stable overexpression of oestrogen receptor-alpha in the human endothelial cell line ECV304* inhibits its growth in vitro, and that this inhibition is possibly mediated through a down-regulation of the vasoactive agents endothelin-1 and vascular endothelial growth factor. Here we show an i...

journal_title：Cell proliferation

authors： Ali SH,O'Donnell AL,Balu D,Pohl MB,Seyler MJ,Mohamed S,Mousa S,Dandona P

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVES:Panax ginseng, a well-known traditional Chinese medicine with multiple pharmacological activities, plays a crucial role in modulating mood disorders. Several recent studies have identified an underlying role of Panax ginseng in the prevention and treatment of depression. However, the cellular and molecular m...

journal_title：Cell proliferation

authors： Jin Y,Cui R,Zhao L,Fan J,Li B

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVES:To investigate the function and regulatory mechanism of Krüppel-like factor 3 (KLF3) in lung cancer. MATERIALS AND METHODS:KLF3 expression was analysed by qRT-PCR and Western blot assays. The proliferation, migration, invasion, cycle and apoptosis were measured by CCK-8 and EdU, wound-healing and Transwell,...

journal_title：Cell proliferation

authors： Wang R,Xu J,Xu J,Zhu W,Qiu T,Li J,Zhang M,Wang Q,Xu T,Guo R,Lu K,Yin Y,Gu Y,Zhu L,Huang P,Liu P,Liu L,De W,Shu Y

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Erythropoietin has been shown to have a protective effect in certain models of ischaemia-reperfusion, and in some cases the protection has been correlated with activation of signalling pathways known to play a role in cell survival and proliferation. We have studied whether erythropoietin would overcome direc...

journal_title：Cell proliferation

authors： Andreucci M,Fuiano G,Presta P,Lucisano G,Leone F,Fuiano L,Bisesti V,Esposito P,Russo D,Memoli B,Faga T,Michael A

更新日期：2009-08-01 00:00:00

abstract：:In this paper we describe the application of a non-radioactive DNA double labelling and staining method to an analysis of cell proliferation kinetics by flow cytometry, aimed at the direct measurement of recruitment rates in cell cultures. The method is based on the application of two halogenated deoxyuridines: iodode...

journal_title：Cell proliferation

authors： Bakker PJ,de Vries RJ,Tukker CJ,Hoebe RA,Barendsen GW

更新日期：1993-01-01 00:00:00

abstract：:The validity of the use of the monoclonal antibodies Ki-67 and anti-BrdUrd to evaluate proliferative activity of human prostate tumour models was studied. Growth of the transplantable PC-82 and PC-EW prostate tumours, as assessed by tumour volume measurements, was significantly correlated with the proliferative activi...

journal_title：Cell proliferation

authors： van Weerden WM,Moerings EP,van Kreuningen A,de Jong FH,van Steenbrugge GJ,Schröder FH

更新日期：1993-01-01 00:00:00

abstract：:In vitro cultured Ehrlich ascites tumour (EAT) cells were used because of the ease of their manipulation under different levels of hypoxia. They were used to clarify further the complex mechanism of oxygen-dependent cell proliferation. On reducing the oxygen concentration from 20% to lower levels (1-7%) an increase in...

journal_title：Cell proliferation

authors： Löffler M

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:MicroRNAs (miRNAs) as small non-coding RNA molecules act by negatively regulating their target genes. Recent studies have shown that protein phosphatase Mg2+/Mn2+-dependent 1F (PPM1F) plays a critical role in cancer metastasis. But, the regulation mechanisms of PPM1F by miRNAs in gastric cancer (GC) remain u...

journal_title：Cell proliferation

authors： Zhang J,Jin M,Chen X,Zhang R,Huang Y,Liu H,Zhu J

更新日期：2018-08-01 00:00:00

abstract：:The effect of various GnRH analogues, and their conjugates on proliferation, clonogenicity and cell cycle phase distribution of MCF-7 and Ishikawa human cancer cell lines was studied. GnRH-III, a sea lamprey GnRH analogue reduced cell proliferation by 35% and clonogenicity by 55%. Structural modifications either decre...

journal_title：Cell proliferation

authors： Kálnay A,Pályi I,Vincze B,Mihalik R,Mezõ I,Pató J,Seprõdi J,Lovas S,Murphy RF

更新日期：2000-10-01 00:00:00

abstract：:Human epidemiological reports and rodent experimental research data indicate a possible chemopreventive effect of regular aspirin use for decreasing risk of colon and rectum cancer incidence and mortality. We have previously demonstrated that aspirin can significantly suppress proliferative parameters in normal rat co...

journal_title：Cell proliferation

authors： Barnes CJ,Lee M,Hardman WE,Cameron IL

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVES:The present study aimed to investigate overall effect of quercetin on proliferation and osteogenic differentiation of mouse adipose stem cells (mASCs) in vitro. MATERIALS AND METHODS:Mouse adipose stem cells were isolated from subcutaneous fat pads and induced into the osteogenic lineage. Effects of quercet...

journal_title：Cell proliferation

authors： Zhou C,Lin Y

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:Steroid-induced osteonecrosis of the femoral head (ONFH) is a common orthopaedic disease of which early detection remains clinically challenging. Accumulating evidences indicated that circulating microRNAs (miRNAs) plays vital roles in the development of several bone diseases. However, the association betwee...

journal_title：Cell proliferation

authors： Li Z,Jiang C,Li X,Wu WKK,Chen X,Zhu S,Ye C,Chan MTV,Qian W

更新日期：2018-02-01 00:00:00