Does the lack of regression-associated mRNA expression render a rat ventral prostate epithelial cell line androgen independent?

abstract：:Hepatocytes can be generated from embryonic stem cells (ESCs) using inducers such as chemical compounds and cytokines, but issues related to low differentiation efficiencies remain to be resolved. Recent work has shown that overexpression of lineage-specific transcription factors can directly cause cells phenotypic ch...

journal_title：Journal of cellular biochemistry

authors： Liu T,Zhang S,Xiang D,Wang Y

更新日期：2013-11-01 00:00:00

abstract：:We observed that treatment of prostate cancer cells for 24 h with magnolol, a phenolic component extracted from the root and stem bark of the oriental herb Magnolia officinalis, induced apoptotic cell death in a dose- and time-dependent manner. A sustained inhibition of the major survival signal, Akt, occurred in magn...

journal_title：Journal of cellular biochemistry

authors： Lee DH,Szczepanski MJ,Lee YJ

更新日期：2009-04-15 00:00:00

abstract：:Protein synthesis inhibitors paradoxically increase the expression of early-gene products, including various cytokines, through a process known as superinduction. Superinduction is cell-specific and the mechanisms involved are not fully understood but are usually attributed to decreased mRNA degradation. There is, how...

journal_title：Journal of cellular biochemistry

authors： Hershko DD,Robb BW,Wray CJ,Luo GJ,Hasselgren PO

更新日期：2004-04-01 00:00:00

abstract：:Inoculations with antigen-expressing plasmid DNAs (DNA vaccines) in the production of protective immune responses. Since the initial development of DNA vaccines more than 5 years ago, major strides have been made in the design of efficient vaccine vectors and in the process of vaccine delivery. However, many questions...

journal_title：Journal of cellular biochemistry

authors： Feltquate DM

更新日期：1998-01-01 00:00:00

abstract：:Alkaptonuria (AKU) is a rare genetic disease associated with the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues up to the deposition of melanin-like pigments (ochronosis). Since little is known on the effects of HGA and its metabolites on articular cells, we carried...

journal_title：Journal of cellular biochemistry

authors： Braconi D,Laschi M,Taylor AM,Bernardini G,Spreafico A,Tinti L,Gallagher JA,Santucci A

更新日期：2010-11-01 00:00:00

abstract：:Colorectal neoplasia differentially expressed (CRNDE) is a significantly upregulated long noncoding RNA in hepatocellular carcinoma (HCC). CRNDE could promote cell proliferation, migration, and invasion, while its molecular mechanisms were still largely unclear. In this study, we investigated the expression and functi...

journal_title：Journal of cellular biochemistry

authors： Zhu L,Yang N,Du G,Li C,Liu G,Liu S,Xu Y,Di Y,Pan W,Li X

更新日期：2018-11-14 00:00:00

abstract：:Metastatic variant cell lines of the murine RAW117 large cell lymphoma were used to study the cell surface components involved in syngeneic tumor cell/microvessel endothelial cell interactions. Poorly liver-metastatic parental RAW117-P cell line adhered to murine hepatic sinusoidal endothelial cell monolayers at signi...

journal_title：Journal of cellular biochemistry

authors： Tressler RJ,Nicolson GL

更新日期：1992-02-01 00:00:00

abstract：:Glioblastoma (GB) has a poor prognosis, despite current multimodality treatment. Beside surgical resection, adjuvant ionizing radiation (IR) combined with Temozolomide (TMZ) drug administration is the standard therapy for GB. This currently combined radio-chemotherapy treatment resulted in glial tumor cell death induc...

journal_title：Journal of cellular biochemistry

authors： Palumbo S,Pirtoli L,Tini P,Cevenini G,Calderaro F,Toscano M,Miracco C,Comincini S

更新日期：2012-07-01 00:00:00

abstract：:Tumor cells display different bioenergetic profiles when compared to normal cells. In the present work we showed metabolic reprogramming by means of inhibitors of histone deacetylase (HDACis), sodium butyrate and trichostatin A in breast cancer cells representing different stages of aggressiveness and metabolic profil...

journal_title：Journal of cellular biochemistry

authors： Rodrigues MF,Carvalho É,Pezzuto P,Rumjanek FD,Amoêdo ND

更新日期：2015-05-01 00:00:00

abstract：:Copy number variation (CNV) and abnormal expression of microRNAs (miRNAs) always lead to deregulation of genes in cancer, including gastric cancer (GC). However, little is known about how CNVs affect the expression of miRNAs. By integrating CNV and miRNA profiles in the same samples, we identified eight miRNAs (miR-12...

journal_title：Journal of cellular biochemistry

authors： An J,Pan Y,Yan Z,Li W,Cui J,Yuan J,Tian L,Xing R,Lu Y

更新日期：2013-09-01 00:00:00

abstract：:Bone formation is under the control of a set of transcription factors. Ids are inhibitory helix-loop-helix (HLH) transcription factors and expression of Id genes in osteoblasts is under the control of calciotropic agents such as BMP and vitamin D. However, the function of Ids during bone formation in vivo has not yet ...

journal_title：Journal of cellular biochemistry

authors： Maeda Y,Tsuji K,Nifuji A,Noda M

更新日期：2004-10-01 00:00:00

abstract：:Muscarinic acetylcholine receptors (mAChRs) regulate diverse cellular functions, including cell growth and proliferation, via multiple signaling pathways. Previously, we showed that mAChRs stimulate the MEK1/2-ERK1/2-RSK pathway in SNU-407 colon cancer cells and subsequently promote cell proliferation. In this study, ...

journal_title：Journal of cellular biochemistry

authors： Park YS,Liu Z,Vasamsetti BM,Cho NJ

更新日期：2016-12-01 00:00:00

abstract：:Syndecans are proteoglycans that act as signaling molecules. Previously, we showed that syndecan-2 (SYND2) is involved in the control of osteoblastic (OB) cell apoptosis. Here, we show a novel functional interaction between SYND2 and protein kinase C delta (PKCdelta). Overexpression of SYND2 in MG63 OB cells resulted ...

journal_title：Journal of cellular biochemistry

authors： Orosco A,Fromigué O,Haÿ E,Marie PJ,Modrowski D

更新日期：2006-07-01 00:00:00

abstract：:Hepassocin (HPS) is a specific mitogenic active factor for hepatocytes, and inhibits growth by overexpression in hepatocellular carcinoma (HCC) cells. However, the mechanism of HPS regulation on growth of liver-derived cells still remains largely unknown. In this study, we found that HPS was expressed and secreted int...

journal_title：Journal of cellular biochemistry

authors： Cao MM,Xu WX,Li CY,Cao CZ,Wang ZD,Yao JW,Yu M,Zhan YQ,Wang XH,Tang LJ,Chen H,Li W,Ge CH,Yang XM

更新日期：2011-10-01 00:00:00

abstract：:Prostate cancer has a propensity to metastasize to the bone. Currently the only effective systemic treatment for these patients is androgen ablation therapy. However, the tumor will invariably progress to an androgen-independent stage and the patient will succumb to his disease within approximately 2 years. The earlie...

journal_title：Journal of cellular biochemistry

authors： Wang G,Sadar MD

更新日期：2006-05-01 00:00:00

abstract：:The protective effect of melatonin, 6-hydroxymelatonin and N-acetylserotonin against alpha-naphthylisothiocyanate (ANIT)-induced liver injury was investigated and compared in rats injected once with the hepatotoxicant (75 mg/kg body weight). In rats injected with ANIT alone, liver injury with cholestasis developed wit...

journal_title：Journal of cellular biochemistry

authors： Calvo JR,Reiter RJ,García JJ,Ortiz GG,Tan DX,Karbownik M

更新日期：2001-01-01 00:00:00

abstract：:The mitogen regulated protein/proliferin (MRP/PLF) gene is transcribed in primary mouse embryo fibroblasts (MEFs), but the pre-mRNA is not properly converted into a stable cytoplasmic mRNA and instead is rapidly degraded, apparently in the nucleus [Malyankar et al. (1994): Proc Natl Acad Sci USA 91:335-359]. In 3T3 ce...

journal_title：Journal of cellular biochemistry

authors： Malyankar UM,Rittling SR,Denhardt DT

更新日期：1996-02-01 00:00:00

abstract：:The spatial and temporal coordination of the many events required for osteogenic cells to create a mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product, demand that these cells have mechanisms to carefully monitor events in the extracellular environment ...

journal_title：Journal of cellular biochemistry

authors： Beck GR Jr

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Gram-negative bacterium, Helicobacter pylori is notorious for various pathologies like peptic ulcers, gastritis, functional dyspepsia, and various cancers. METHODS:Systemic effects of its toxins have led scientists' attention toward the extragastric pathologies associated with it. To date, it has been shown...

journal_title：Journal of cellular biochemistry

authors： Zendehdel A,Roham M

更新日期：2019-08-01 00:00:00

abstract：:Chicken histone H5 is an H1-like linker histone that is expressed only in nucleated erythrocytes. The histone H5 promoter has binding sites for Sp1 (a high affinity site) and UPE-binding protein, while the 3' erythroid-specific enhancer has binding sites for Sp1 (one moderate and three weak affinity), GATA-1, and NF1....

journal_title：Journal of cellular biochemistry

authors： Sun JM,Chen HY,Davie JR

更新日期：1994-06-01 00:00:00

abstract：:The selenium-based compound ebselen is a powerful antioxidant, a potent anti-inflammatory agent and a potential neuroprotective compound. Several studies have demonstrated that part of the biological effect of ebselen is the result of the inhibition of apoptosis. We show in this report that ebselen induced the necroti...

journal_title：Journal of cellular biochemistry

authors： Guérin PJ,Gauthier ER

更新日期：2003-05-01 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases have been implicated as important mediators of the inflammatory response. Here we report that c-Jun NH(2)-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 MAP kinase activities are reprogrammed during the IL-6 induced macrophage-like differentiation of...

journal_title：Journal of cellular biochemistry

authors： Hall JP,Davis RJ

更新日期：2002-01-01 00:00:00

abstract：:The complex nuclear structure of somatic cells is important to epigenomic regulation, yet little is known about nuclear organization of human embryonic stem cells (hESC). Here we surveyed several nuclear structures in pluripotent and transitioning hESC. Observations of centromeres, telomeres, SC35 speckles, Cajal Bodi...

journal_title：Journal of cellular biochemistry

authors： Butler JT,Hall LL,Smith KP,Lawrence JB

更新日期：2009-07-01 00:00:00

abstract：:microRNA (miRNA) is a family of small, non-coding RNA first discovered as an important regulator of development in Caenorhabditis elegans (C. elegans). Numerous miRNAs have been found in C. elegans, and some of them are well conserved in many organisms. Though, the biologic function of miRNAs in C. elegans was largely...

journal_title：Journal of cellular biochemistry

authors： Liu J,Yang B,Ai J

更新日期：2013-05-01 00:00:00

abstract：:It is possible to convert milk glands of transgenic animals into bioreactors producing heterologous proteins such as scarce human pharmaceuticals. To predictably and successfully engineer the milk gland, we will need a thorough understanding of its physiology. Expression studies in transgenic animals have located mamm...

journal_title：Journal of cellular biochemistry

authors： Hennighausen L

更新日期：1992-08-01 00:00:00

abstract：:TNF-a is an important cytokine mediator of inflammation which suggests that inhibition of TNF activity may provide potential for clinical application. Recent data indicated that treatment of both human and mouse cells with Kavain significantly modulates P. gingivalis- and LPS-induced TNF-α expression. In order to obta...

journal_title：Journal of cellular biochemistry

authors： Tang X,Alasiri M,Bamashmous A,Aljahdali B,Cao F,Dibart S,Salih E

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:A critical feature for fibroblasts differentiation into myofibroblasts is the expression of alpha-smooth muscle actin (α-SMA) during the tissue injury and repair process. The epigenetic mechanism, DNA methylation, is involved in regulating α-SMA expression. It is not clear how methyl-CpG-binding protein 2 (M...

journal_title：Journal of cellular biochemistry

authors： Xiang Z,Zhou Q,Hu M,Sanders YY

更新日期：2020-07-01 00:00:00

abstract：:We have previously demonstrated that the ultraviolet (UV) light is effective against a variety of cancer cells in vivo as well as in vitro. In the present report, we imaged the DNA damage repair response of minimal cancer after UVC irradiation. DNA-damage repair response to UV irradiation was imaged on tumors growing ...

journal_title：Journal of cellular biochemistry

authors： Miwa S,Yano S,Hiroshima Y,Tome Y,Uehara F,Mii S,Efimova EV,Kimura H,Hayashi K,Tsuchiya H,Hoffman RM

更新日期：2013-11-01 00:00:00

abstract：:Diastolic cardiac dysfunction can be caused by abnormality in cTnI expression during cardiogenesis. In this study, we investigated the effects of estrogen on the abnormal expression of cTnI in the hearts of neonatal mice and its potential epigenetic mechanisms. We then evaluated suberoylanilide hydroxamic acid (SAHA),...

journal_title：Journal of cellular biochemistry

authors： Peng C,Luo X,Xing Q,Sun H,Huang X

更新日期：2016-10-01 00:00:00

abstract：:Phospholipase C-gamma1 (PLCgamma1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5-inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCgamma1 in PLCgamma1-mediated cell signaling, we characterized some protei...

journal_title：Journal of cellular biochemistry

authors： Bae JY,Ahn SJ,Lee JE,Kim JE,Han MR,Han W,Kim SW,Shin HJ,Lee SJ,Park D,Noh DY

更新日期：2005-04-01 00:00:00