Imaging UVC-induced DNA damage response in models of minimal cancer.

abstract：:Therapeutic strategies targeting both cancer cells and associated cells in the tumor microenvironment offer significant promise in cancer therapy. We previously reported that generation 5 (G5) dendrimers conjugated with cyclic-RGD peptides target cells expressing integrin alpha V beta 3. In this study, we report a nov...

journal_title：Journal of cellular biochemistry

authors： Hill EE,Kim JK,Jung Y,Neeley CK,Pienta KJ,Taichman RS,Nor JE,Baker JR Jr,Krebsbach PH

更新日期：2018-11-01 00:00:00

abstract：:The role of regucalcin in the regulation of osteoblastic cell function was investigated. Osteoblastic MC3T3-E1 cells with subconfluent monolayers were cultured in a medium containing regucalcin (10(-10)-10(-8) M) without fetal bovine serum (FBS). The proliferation of osteoblastic cells was not significantly altered in...

journal_title：Journal of cellular biochemistry

authors： Yamaguchi M,Kobayashi M,Uchiyama S

更新日期：2005-10-15 00:00:00

abstract：:Extracellular matrix (ECM) accumulation plays a key role in the progression of bladder outlet obstruction (BOO). Muscarinic receptors have been widely reported to serve as pivotal regulators in lung tissue remodeling. However, the influence of them on human bladder smooth muscle cells (HBSMCs) and the underlying molec...

journal_title：Journal of cellular biochemistry

authors： Chen S,Liao B,Jin X,Wei T,He Q,Lin Y,Ai J,Gong L,Li H,Wang K

更新日期：2020-11-01 00:00:00

abstract：:Ligamentum flavum (LF)-derived mesenchymal stem cells (MSCs) have been implicated in the pathogenesis of calcification of the ligamentum flavum (CLF) leading to the increased presence of chondrocyte-like cells and calcium deposition in CLF; however, the mechanisms of LF-MSCs in differentiation are not defined. In this...

journal_title：Journal of cellular biochemistry

authors： Zhang Q,Wang S,Sheng Y,Zhao S,Jiang Y,Zhou D,Yang H

更新日期：2019-03-01 00:00:00

abstract：:Recently, glioma stem cells have been identified as the main cause of glioma propagation and recurrence and a number of several cell markers have been indicated as putative GSC markers. In the present work, a retrospective study to evaluate the prognostic potential of ability to generate GSCs in our series of 15 gliob...

journal_title：Journal of cellular biochemistry

authors： Miconi G,Palumbo P,Dehcordi SR,La Torre C,Lombardi F,Evtoski Z,Cimini AM,Galzio R,Cifone MG,Cinque B

更新日期：2015-05-01 00:00:00

abstract：:Carboxylic acids have various biological activities and play critical roles in cellular metabolic pathways such as the tricarboxylic acid (TCA) cycle. It has been shown that some carboxylic acids induce cell proliferation and production of cytokines or growth factors. However, there have been no reports on effects of ...

journal_title：Journal of cellular biochemistry

authors： Motoki T,Sugiura Y,Matsumoto Y,Tsuji T,Kubota S,Takigawa M,Gohda E

更新日期：2008-07-01 00:00:00

abstract：:Weightlessness induces bone loss in humans and animal models. We employed the NASA-approved Rotating Wall Vessel bioreactor (RWV) to develop osteoblast-like cell cultures under microgravity and evaluate osteoblast phenotype and cell function. Rat osteoblast-like cell line (ROS.SMER#14) was grown in the RWV at a calcul...

journal_title：Journal of cellular biochemistry

authors： Rucci N,Migliaccio S,Zani BM,Taranta A,Teti A

更新日期：2002-01-01 00:00:00

abstract：:The aim of this study was to investigate the role of NYD-SP15 in the growth and oxidative-stress responses of ARPE-19 cells. ARPE-19 cell lines overexpressing wild type or RNA interference against NYD-SP15 were established via lentivirus transfection. Cell growth and proliferation, migration, apoptosis, and cell cycle...

journal_title：Journal of cellular biochemistry

authors： Xu Y,Wang L,Cao L,Chen L,Liu Q

更新日期：2018-10-28 00:00:00

abstract：:Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), provide a new cell source for regenerative medicine, disease modeling, drug discovery, and preclinical toxicity screening. Understanding of the onset and the sequential process of hemat...

journal_title：Journal of cellular biochemistry

authors： Chen T,Wang F,Wu M,Wang ZZ

更新日期：2015-07-01 00:00:00

abstract：:We have previously shown that protein kinase Cε (PKCε) is involved in mitochondrial dysfunction in renal proximal tubular cells (RPTC). This study examined mitochondrial targets of active PKCε in RPTC injured by the model oxidant tert-butyl hydroperoxide (TBHP). TBHP exposure augmented the levels of phosphorylated (ac...

journal_title：Journal of cellular biochemistry

authors： Nowak G,Bakajsova-Takacsova D

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:This study was designed to explore the protective effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against ischemia/reperfusion (I/R) injury-induced cardiomyocytes apoptosis. METHODS:The H9c2 cell I/R injury model was induced by simultaneous shortage of nutrients and oxygen. TSG administration...

journal_title：Journal of cellular biochemistry

authors： Sun T,Liu H,Cheng Y,Yan L,Krittanawong C,Li S,Qian W,Su W,Chen X,Hou X,Zhang H

更新日期：2019-03-19 00:00:00

abstract：:Chromium(VI) resistant Chinese hamster ovary (CHO) cell lines were established in this study by exposing parental CHO-K1 cells to sequential increases in CrO3 concentration. The final concentration of CrO3 used for selection was 7 microM for Cr7 and 16 microM for Cr16 cells. Cr16-1 was a subclone derived from Cr16 cel...

journal_title：Journal of cellular biochemistry

authors： Lu YY,Yang JL

更新日期：1995-04-01 00:00:00

abstract：:Osterix belongs to the SP gene family and is a core transcription factor responsible for osteoblast differentiation and bone formation. Activation of protein kinase A (PKA), a serine/threonine kinase, is essential for controlling bone formation and BMP-induced osteoblast differentiation. However, the relationship betw...

journal_title：Journal of cellular biochemistry

authors： He S,Choi YH,Choi JK,Yeo CY,Chun C,Lee KY

更新日期：2014-10-01 00:00:00

abstract：:Phospholipase C-gamma1 (PLCgamma1) plays a critical role in cell growth and proliferation by generating the second messengers, diacylglycerol and 1, 4, 5-inositol triphosphate. To investigate the roles of Src homology domain 2 and domain 3 of PLCgamma1 in PLCgamma1-mediated cell signaling, we characterized some protei...

journal_title：Journal of cellular biochemistry

authors： Bae JY,Ahn SJ,Lee JE,Kim JE,Han MR,Han W,Kim SW,Shin HJ,Lee SJ,Park D,Noh DY

更新日期：2005-04-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a structurally unique nonreceptor protein-tyrosine kinase that localizes to focal adhesion plaques. Regulation of its activity has been implicated in diverse signaling pathways, including those mediated by extracellular matrix/integrin interactions, G-protein coupled receptors for mitoge...

journal_title：Journal of cellular biochemistry

authors： Polte TR,Naftilan AJ,Hanks SK

更新日期：1994-05-01 00:00:00

abstract：:Based on a consideration of the probable structure of calmodulin and some natural peptides known to interact with it, two calmodulin-binding peptides were designed. These peptides bind to calmodulin in helical conformations and are capable of forming electrostatic and hydrophobic interactions with calmodulin. Their di...

journal_title：Journal of cellular biochemistry

authors： DeGrado WF,Prendergast FG,Wolfe HR Jr,Cox JA

更新日期：1985-01-01 00:00:00

abstract：:Heme oxygenase (HO-1) is a stress protein that has been suggested to participate in defense mechanisms against agents that induce oxidative injury such as hemoglobin/heme, hypoxia-ischemia and cytokines. Overexpression of HO-1 in endothelial cells (EC) might, therefore, protect against oxidative stress produced under ...

journal_title：Journal of cellular biochemistry

authors： Deramaudt BM,Braunstein S,Remy P,Abraham NG

更新日期：1998-01-01 00:00:00

abstract：:Several gap junction connexins have been shown to be essential for appropriate placental development and function. It is known that the expression and distribution of connexins change in response to environmental oxygen levels. The placenta develops under various oxygen levels, beginning at a low oxygen tension of app...

journal_title：Journal of cellular biochemistry

authors： Otto T,Gellhaus A,Lüschen N,Scheidler J,Bendix I,Dunk C,Wolf N,Lennartz K,Köninger A,Schmidt M,Kimmig R,Fandrey J,Winterhager E

更新日期：2015-12-01 00:00:00

abstract：:Two monoclonal antibodies that cause changes in the morphology of cultured myogenic cells are described. Antibody JG9 causes myoblasts to round up and causes myotubes to become thin, cable-like structures with multiple round swellings. Antibody JG22 causes both myoblasts and myotubes to become round refractile cells p...

journal_title：Journal of cellular biochemistry

authors： Greve JM,Gottlieb DI

更新日期：1982-01-01 00:00:00

abstract：:Ubiquitin activating enzyme 2 (UBA2) is a basic component of E1-activating enzyme in the SUMOylation system. Expression and function of UBA2 in human cancers are largely unknown. In this study we investigate UBA2 expression the function in human non-small-cell lung cancer. Immunochemistry study showed that UBA2 was ov...

journal_title：Journal of cellular biochemistry

authors： Jiang B,Fan X,Zhang D,Liu H,Fan C

更新日期：2019-08-01 00:00:00

abstract：:Skin epidermis is a constantly renewing epithelium that is composed of various cell types and provides an ideal model system for tissue regeneration and heterogeneity studies. Integrins are a family of transmembrane receptors that mediate cell adhesion in the epidermis, and integrin expression spatially reflects epide...

journal_title：Journal of cellular biochemistry

authors： He W,Ye J,Xu H,Lin Y,Zheng Y

更新日期：2020-03-01 00:00:00

abstract：:AT-rich interaction domain 4A (ARID4A) and AT-rich interaction domain 4B (ARID4B), which are both the AT-rich interaction domain (ARID) family, have been reported to be oncogene or tumor suppressor gene in various human malignances, but there is no involvement about their functions in prostate cancer (PCa). Our previo...

journal_title：Journal of cellular biochemistry

authors： Liang YK,Han ZD,Lu JM,Liu ZZ,Zhuo YJ,Zhu XJ,Chen JX,Ye JH,Liang YX,He HC,Zhong WD

更新日期：2018-09-01 00:00:00

abstract：:Curcumin, the active component of the spice turmeric, induce global DNA hypomethylation as it has been shown to inhibit DNA methyltransferases. It promotes cell death in cancer cells by arresting in the G1 phase. It was explained to cause increased expression of cell cycle regulator, p21 (WAF1/Cip1); however, the mech...

journal_title：Journal of cellular biochemistry

authors： Chatterjee B,Ghosh K,Kanade SR

更新日期：2019-01-01 00:00:00

abstract：:Several molecules extracted from natural products exhibit different biological activities, such as ion channel modulation, activation of signaling pathways, and anti-inflammatory or antitumor activity. In this study, we tested the antitumor ability of natural compounds extracted from the Raputia praetermissa plant. Am...

journal_title：Journal of cellular biochemistry

authors： Vital WD,Torquato HFV,Jesus LOP,Judice WAS,Silva MFDGFD,Rodrigues T,Justo GZ,Veiga TAM,Paredes-Gamero EJ

更新日期：2019-06-01 00:00:00

abstract：:DNA methylation has been studied with regard to chemotherapeutics for a number of years. The radiation field has just begun to look at this in the context of radiotherapy or radiation exposure. So far, the data suggest that radiation induces epigenetic reprogramming which indicates a purposeful response that influence...

journal_title：Journal of cellular biochemistry

authors： Zielske SP

更新日期：2015-02-01 00:00:00

abstract：:The role of TatD DNases as DNA repair enzymes or cell death (apoptotic) nucleases is well established in prokaryotes as well as eukaryotes. The current study aims to characterize the TatD nuclease from Bacillus anthracis (Ba TatD) and to explore its key histidine catalytic residues. Ba TatD was found to be a metal-dep...

journal_title：Journal of cellular biochemistry

authors： Singh D,Rahi A,Kumari R,Gupta V,Gautam G,Aggarwal S,Rehan M,Bhatnagar R

更新日期：2019-02-05 00:00:00

abstract：:The inhibitor of growth (ING) family of proteins is an evolutionarily conserved family, with members present from yeast to humans. The mammalian ING proteins are candidate tumor suppressor proteins and accordingly can cooperate with p53 to arrest proliferation and induce apoptosis. ING proteins are also reported to fu...

journal_title：Journal of cellular biochemistry

authors： Shi X,Gozani O

更新日期：2005-12-15 00:00:00

abstract：:Previously we have shown that transforming growth factor beta (TGF beta) 1, basic fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) BB inhibit the synthesis of insulin-like growth factor (IGF) II, but their effects on IGF binding protein (IGFBP)-6 in osteoblast cultures are not known. IGFBP-6 b...

journal_title：Journal of cellular biochemistry

authors： Gabbitas B,Canalis E

更新日期：1997-07-01 00:00:00

abstract：:Laryngocarcinoma is the most common head and neck cancer and has a high incidence and mortality, causing about 83 000 deaths per year worldwide. Our research aimed to investigate the possible role of long noncoding RNA (lncRNA) taurine upregulated gene 1 (TUG1) in laryngocarcinoma development. The messenger RNA (mRNA)...

journal_title：Journal of cellular biochemistry

authors： Zhuang S,Liu F,Wu P

更新日期：2019-08-01 00:00:00

abstract：:Platelets, which play a central role in thrombosis and hemostasis, develop from megakaryocytes. Signal transduction originated from the megakaryocyte growth and development factor, the Mpl ligand, which leads to megakaryocyte differentiation, polyploidization, and maturation, has been gradually characterized. In this ...

journal_title：Journal of cellular biochemistry

authors： Sun S,Ravid K

更新日期：1999-11-01 00:00:00