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Hepassocin regulates cell proliferation of the human hepatic cells L02 and hepatocarcinoma cells through different mechanisms.

Abstract：

:Hepassocin (HPS) is a specific mitogenic active factor for hepatocytes, and inhibits growth by overexpression in hepatocellular carcinoma (HCC) cells. However, the mechanism of HPS regulation on growth of liver-derived cells still remains largely unknown. In this study, we found that HPS was expressed and secreted into the extracellular medium in cultured L02 human hepatic cells; conditional medium of L02 cells promoted proliferation of L02 cells and this activity could be blocked by anti-HPS antibody. Moreover, we identified the presence of receptor for HPS on L02 cells and HepG2 human hepatoma cells. Overproduction of truncated HPS, which signal peptide was deleted, significantly inhibited the proliferation of HCC cells and induced cell cycle arrest. These findings suggest that HPS promotes hepatic cell line L02 cells proliferation via an autocrine mechanism and inhibits HCC cells proliferation by an intracrine pathway.

journal_name

J Cell Biochem

journal_title

Journal of cellular biochemistry

authors

Cao MM,Xu WX,Li CY,Cao CZ,Wang ZD,Yao JW,Yu M,Zhan YQ,Wang XH,Tang LJ,Chen H,Li W,Ge CH,Yang XM

doi

10.1002/jcb.23202

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

2882-90

issue

10

eissn

0730-2312

issn

1097-4644

journal_volume

112

pub_type

杂志文章

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