Arsenite stimulates cyclooxygenase-2 expression through activating IkappaB kinase and nuclear factor kappaB in primary and ECV304 endothelial cells.

abstract：:Osteopontin is a multifunctional matricellular protein identified as one of the most upregulated genes in pulmonary fibrosis. Experimental animal models have identified early pro-fibrotic cytokines as essential to the pathogenesis of inflammation-induced pulmonary fibrosis. However, the principal sources of osteoponti...

journal_title：Journal of cellular biochemistry

authors： Serlin DM,Kuang PP,Subramanian M,O'Regan A,Li X,Berman JS,Goldstein RH

更新日期：2006-02-15 00:00:00

abstract：:Deregulation of microRNAs contributes to the abnormal cell growth which is frequently observed in cancer. In the current study, we detected the expression and regulatory relationship between miR-10a and Lysine-specific demethylase 4A (KDM4A) to reveal their function in prostate cancer (PCa) progression. We found that ...

journal_title：Journal of cellular biochemistry

authors： Mu H,Xiang L,Li S,Rao D,Wang S,Yu K

更新日期：2019-04-01 00:00:00

abstract：:The non-receptor tyrosine kinase c-Src is activated in many human cancer types, and induces deregulation of cadherin-based cell-cell contacts and actin cytoskeleton. Because ezrin, a protein which cross-links the plasma membrane with the actin cytoskeleton, is often over-expressed in human cancers, and participates in...

journal_title：Journal of cellular biochemistry

authors： Elliott BE,Qiao H,Louvard D,Arpin M

更新日期：2004-05-01 00:00:00

abstract：:Choline-deficiency causes liver cells to die by apoptosis, and it has not been clear whether the effects of choline-deficiency are mediated by methyl-deficiency or by lack of choline moieties. SV40 immortalized CWSV-1 hepatocytes were cultivated in media that were choline-sufficient, choline-deficient, choline-deficie...

journal_title：Journal of cellular biochemistry

authors： Shin OH,Mar MH,Albright CD,Citarella MT,da Costa KA,Zeisel SH

更新日期：1997-02-01 00:00:00

abstract：:The perinucleolar compartment (PNC) is a distinct nuclear body that localizes to the nucleolar periphery. The PNC is predominantly found in cancer cells, and recent evidence suggests that PNC prevalence can be a pan-cancer marker for tumors of solid tissue origin. The PNC is a heritable structure enriched with newly t...

journal_title：Journal of cellular biochemistry

authors： Pollock C,Huang S

更新日期：2009-05-15 00:00:00

abstract：:Protein synthesis inhibitors paradoxically increase the expression of early-gene products, including various cytokines, through a process known as superinduction. Superinduction is cell-specific and the mechanisms involved are not fully understood but are usually attributed to decreased mRNA degradation. There is, how...

journal_title：Journal of cellular biochemistry

authors： Hershko DD,Robb BW,Wray CJ,Luo GJ,Hasselgren PO

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:This study aimed to identify factors that affect the prognosis of budesonide therapy for Crohn's disease patients. METHOD:Change in Crohn's disease activity index (CDAI) scores at latest follow-up after budesonide therapy reported by individual studies were pooled to gain overall effect size under random ef...

journal_title：Journal of cellular biochemistry

authors： Li Y,Meng X,Duan X,Tang T,He C,Li Y

更新日期：2019-06-01 00:00:00

abstract：:The expression of receptors belonging to the epidermal growth factor receptor subfamily has been largely studied these last years in epithelial cells mainly as involved in cell proliferation and malignant progression. Although much work has focused on the role of these growth factor receptors in the differentiation of...

journal_title：Journal of cellular biochemistry

authors： Pagano E,Calvo JC

更新日期：2003-10-15 00:00:00

abstract：:3-Acetyl-11-keto-β-boswellic acid (AKBA), a pentacyclic triterpenic acid present in gum resin of Boswellia serrata, has been found to possess antioxidant and neuroprotective properties. In this study, we aimed to examine protective properties of AKBA against glutamate-induced neuronal injury. To investigate the effect...

journal_title：Journal of cellular biochemistry

authors： Rajabian A,Sadeghnia HR,Hosseini A,Mousavi SH,Boroushaki MT

更新日期：2020-02-01 00:00:00

abstract：:Countercurrent centrifugal elutriation was used to separate growth plate chondrocytes from porcine basing on their differences in sizes and densities. Eighteen fractions of cells with different sizes and densities were obtained. The mean cellular volumes increased progressively in each of successive fractions, and tha...

journal_title：Journal of cellular biochemistry

authors： Lee KM,Fung KP,Leung PC,Leung KS

更新日期：1996-03-15 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) increases steady-state mRNA levels of several extracellular matrix proteins in mineralized connective tissues. Bone sialoprotein (BSP) is a major constituent of the bone matrix, thought to initiate and regulate the formation of mineral crystals. To determine the molecular pat...

journal_title：Journal of cellular biochemistry

authors： Ogata Y,Niisato N,Furuyama S,Cheifetz S,Kim RH,Sugiya H,Sodek J

更新日期：1997-06-15 00:00:00

abstract：:Many cases of acute myelogenous leukemia (AML) are characterized by non-random chromosomal translocations that fuse a DNA-binding protein with a transcriptional regulator, which in turn may aberrantly recruit a co-repressor complex. The similarities in this pattern between different AML chimeric fusions have led to a ...

journal_title：Journal of cellular biochemistry

authors： Redner RL,Liu JM

更新日期：2005-04-01 00:00:00

abstract：:Amyloid-β protein (Aβ) is the main component of senile plaques in the brains of Alzheimer disease (AD) patients. Aβ is proteolytically derived from amyloid-β precursor protein by β- and γ-secretases. Secreted Aβ is then eliminated from the central nervous system by multiple clearance mechanisms, including phagocytosis...

journal_title：Journal of cellular biochemistry

authors： Kikuchi K,Kidana K,Tatebe T,Tomita T

更新日期：2017-12-01 00:00:00

abstract：:Optimization of an in vitro culture that supports blastocyst (BL) development from single blastomeres (SBs) is essential to generate additional embryos for farm animals and humans and unravel the mechanisms that underlie totipotency. In this study, we have examined BL development from SBs that were derived from 2-cell...

journal_title：Journal of cellular biochemistry

authors： Yekani F,Azarnia M,Esfandiari F,Hassani SN,Baharvand H

更新日期：2018-09-01 00:00:00

abstract：:Allele-specific transcription is a characteristic feature of imprinted genes. Many imprinted genes are also transcribed in a tissue- or cell type-specific manner. Overlapping epigenetic signals must, therefore, modulate allele-specific and tissue-specific expression at imprinted loci. In addition, long-range interacti...

journal_title：Journal of cellular biochemistry

authors： Hanel ML,Lau JC,Paradis I,Drouin R,Wevrick R

更新日期：2005-04-01 00:00:00

abstract：:Cadherin-17 (CDH17) belongs to the cell adhesion cadherin family with a prominent role in tumorigenesis. It is highly expressed in human hepatocellular carcinoma (HCC) and is proposed to be a biomarker and therapeutic molecule for liver malignancy. The present study aims to identify the transcription factors which int...

journal_title：Journal of cellular biochemistry

authors： Zhu R,Wong KF,Lee NP,Lee KF,Luk JM

更新日期：2010-10-15 00:00:00

abstract：:Little is known about how adhesion molecules on APCs accumulate at immunological synapses. We show here that ICAM-1 on APCs is continuously internalized and rapidly recycled back to the interface after antigen-priming T-cell contact. The internalization rate is high in APCs, including Raji B cells and dendritic cells,...

journal_title：Journal of cellular biochemistry

authors： Jo JH,Kwon MS,Choi HO,Oh HM,Kim HJ,Jun CD

更新日期：2010-12-01 00:00:00

abstract：:Cyclosporin A (CsA) induces osteoporosis but not through direct activation of osteoclasts. CsA also inhibits cell-mediated mineralization in marrow stromal cell culture, whereas the tyrphostin AG-1478 increases mineralization. These antagonistic effects on mineralization were used to discern molecules that underwent p...

journal_title：Journal of cellular biochemistry

authors： Stekelenburg J,Klein BY,Ben-Bassat H,Rojansky N

更新日期：1998-10-01 00:00:00

abstract：:Androgen-regulated genes (ARG) are implicated in normal and neoplastic growth of the prostate. Recently, we reported genomic amplification and/or overexpression of a previously known neurotrophic factor, prosaposin, in androgen-independent (AI) or metastatic prostate cancer (PCa) cells and tissues. Prosaposin and/or i...

journal_title：Journal of cellular biochemistry

authors： Koochekpour S,Lee TJ,Wang R,Sun Y,Delorme N,Hiraiwa M,Grabowski GA,Culig Z,Minokadeh A

更新日期：2007-06-01 00:00:00

abstract：:In addition to cholesterol-lowering effect, HMG-CoA reductase inhibition by statins has been shown to have protective effect in many cells type. The loss of vision in retinal degeneration disease associates with oxidative stress and apoptosis in retinal pigment epithelium (RPE) cell. This study was designed to examine...

journal_title：Journal of cellular biochemistry

authors： Qian J,Keyes KT,Long B,Chen G,Ye Y

更新日期：2011-09-01 00:00:00

abstract：:Resistance to therapies, recurrence, and metastasis remain challenging issues for breast cancer patients, particularly for triple-negative and breast cancer stem cells. The activation of the epithelial-to-mesenchymal transition (EMT) plays an indispensable role in the poor prognosis of those types. The accumulating pr...

journal_title：Journal of cellular biochemistry

authors： Koohestanimobarhan S,Salami S,Imeni V,Mohammadi Z,Bayat O

更新日期：2018-09-06 00:00:00

abstract：:Garlic is known as a potent spice and a medicine with broad therapeutic properties ranging from antibacterial to anticancer, antidiabetic, and anticoagulant. Two major proteins of 40 KD and 14 KD constituting approximately 96% of total garlic proteins have been recently purified at our Institute. This immunocytochemic...

journal_title：Journal of cellular biochemistry

authors： Wen GY,Mato A,Wisniewski HM,Malik MN,Jenkins EC,Sheikh AM,Kim KS

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND AND AIM:Perillaldehyde (PAH), one of the major oil components in Perilla frutescens, is very critical to health maintenance, for a wide range of human chronic diseases, including cancers. AMP-activated protein kinase (AMPK) has been implicated in the activation of autophagy in distinct tissues. This study wa...

journal_title：Journal of cellular biochemistry

authors： Zhang Y,Liu S,Feng Q,Huang X,Wang X,Peng Y,Zhao Z,Liu Z

更新日期：2018-10-30 00:00:00

abstract：:This study aimed at elucidating the molecular mechanism of miR-381-3p in cervical cancer progression, which may provide a novel therapeutic target for patients with cervical cancer. The expression of miR-381-3p was confirmed by quantitative reverse transcription polymerase chain reaction. Microarray analysis was condu...

journal_title：Journal of cellular biochemistry

authors： Shang A,Zhou C,Bian G,Chen W,Lu W,Wang W,Li D

更新日期：2019-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is one of the malignant type of breast cancer. Previous study indicated that long noncoding RNA (lncRNA) ZEB1-AS1 was associated with the progression of several cancers. However, its underlying molecular mechanism in TNBC remains to be elucidated. In this study, ZEB1-AS1 expression...

journal_title：Journal of cellular biochemistry

authors： Luo N,Zhang K,Li X,Hu Y

更新日期：2020-10-01 00:00:00

abstract：:In this experiment, the cross-talk betweenNotch and the NF-κB signaling pathway was examined to reveal the mechanism of slowing down the type II collagen (ColII) and aggrecan degeneration affected by inflammatory cytokines. The expression levels of ColII and aggrecan in the intervertebral disc were observed through im...

journal_title：Journal of cellular biochemistry

authors： Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J

更新日期：2018-10-26 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children and adolescents with high rate of incidence, high frequency of recurrence, and high degree of metastasis. This study aimed to investigate the effects of long noncoding RNA antisense ncRNA in the abundant in neuroepithelium area (ANA)/B-cell translocation...

journal_title：Journal of cellular biochemistry

authors： Zhao J,Zhang C,Gao Z,Wu H,Gu R,Jiang R

更新日期：2018-08-01 00:00:00

abstract：:Osteotesticular protein tyrosine phosphatase (OST-PTP; OST), is a signaling molecule which catalyzes the removal of phosphates from tyrosine residues. It is known to be highly regulated in bone cells and has been shown to be important for the in vitro progression from a preosteoblast to a mature, mineralizing cell. Ho...

journal_title：Journal of cellular biochemistry

authors： Yunker LA,Undersander A,Lian JB,Stein GS,Carlson CS,Mauro LJ

更新日期：2004-11-01 00:00:00

abstract：:The sex steroid hormones, androgens and estrogens, via their respective nuclear receptors, regulate bone mineral density in humans and mice. Very little is known about the direct targets of the androgen and estrogen receptors in bone cells. First, models of hormone and receptor deficiency in mouse and human bone are d...

journal_title：Journal of cellular biochemistry

authors： Krum SA

更新日期：2011-02-01 00:00:00

abstract：:Emerging evidence suggests that long noncoding RNAs (lncRNAs) are involved in many biological processes, such as cell growth, differentiation, apoptosis, and autophagy. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), highly expressed in endothelial cells, is well conserved and implicated in endothelia...

journal_title：Journal of cellular biochemistry

authors： Li S,Pan X,Yang S,Ma A,Yin S,Dong Y,Pei H,Bi X,Li W

更新日期：2019-03-01 00:00:00