Perilaldehyde activates AMP-activated protein kinase to suppress the growth of gastric cancer via induction of autophagy.

abstract：:Paxillin is an adapter protein regulating signaling and focal adhesion assembly that has been linked to malignant potential in many malignancies. Overexpression of paxillin has been noted in aggressive tumors. Integrin-mediated binding through the focal adhesion complex is important in metastatic adhesion and is upreg...

journal_title：Journal of cellular biochemistry

authors： Conway WC,Van der Voort van Zyp J,Thamilselvan V,Walsh MF,Crowe DL,Basson MD

更新日期：2006-08-15 00:00:00

abstract：:Prostate cancer is the second highest caused by cancer-related death among males. microRNAs (miRs) have been reported to participate in carcinogenesis, yet their roles in prostate cancer are rarely studied or investigated. Therefore, the present study attempted to explore the effect of miR-137 in prostate cancer via r...

journal_title：Journal of cellular biochemistry

authors： Wu QQ,Zheng B,Weng GB,Yang HM,Ren Y,Weng XJ,Zhang SW,Zhu WZ

更新日期：2019-06-01 00:00:00

abstract：:High concentrations of nonesterified fatty acids (NEFAs) and β-hydroxybutyric acid (BHBA) induce lipid peroxidation, resulting in liver damage. Choline and methionine (Met) can promote energy balance and benefit liver health in transition dairy cows; however, the regulating mechanism remains unclear. In the present st...

journal_title：Journal of cellular biochemistry

authors： Shen J,Sun B,Yu C,Cao Y,Cai C,Yao J

更新日期：2019-11-03 00:00:00

abstract：:The miR-200c has recently been implicated in the epithelial to mesenchymal transition (EMT) process by directly target the EMT related transcriptional factors ZEB1 and ZEB2. The expression of this miRNA is inversely correlated with tumorgenecity and invasiveness in several human cancers. However, little is known about...

journal_title：Journal of cellular biochemistry

authors： Cui J,Cheng Y,Zhang P,Sun M,Gao F,Liu C,Cai J

更新日期：2014-06-01 00:00:00

abstract：:The study was conducted for comparing the effects of 12 DNA damage response gene mutations (CHEK1, CHEK2, RAD51, BRCA1, BRCA2, MLH1, MSH2, ATM, ATR, MDC1, PARP1, and FANCF) on the overall survival (OS) of breast cancer (BC) patients. We searched the Cancer Genome Atlas (TCGA) database from inception to September 2016....

journal_title：Journal of cellular biochemistry

authors： Liu C,Chang H,Li XH,Qi YF,Wang JO,Zhang Y,Yang XH

更新日期：2017-12-01 00:00:00

abstract：:Glioblastoma is one of the most malignant cancers, with a distinguishing dismal prognosis: surgery followed by chemo- and radiotherapy represents the current standard of care, and chemo- and radioresistance underlie disease recurrence and short overall survival of patients suffering from this malignancy. ATM is a kina...

journal_title：Journal of cellular biochemistry

authors： Romano FJ,Guadagno E,Solari D,Borrelli G,Pignatiello S,Cappabianca P,Del Basso De Caro M

更新日期：2018-06-01 00:00:00

abstract：:Na+/D-glucose symport is a secondary active glucose transport mechanism expressed only in kidney proximal tubule and in small intestine. A monoclonal antibody that recognized the Na+/glucose symporter of pig renal brush border membranes also recognized a 75-kD protein in apical membranes isolated from highly different...

journal_title：Journal of cellular biochemistry

authors： Wu JS,Lever JE

更新日期：1989-05-01 00:00:00

abstract：:Phosphoproteins produced by the incubation of crude extracts of Salmonella typhimurium and Escherichia coli with either [32P]phosphoenolpyruvate or [gamma 32P]ATP have been resolved and detected using sodium dodecyl sulphate polyacrylamide gel electrophoresis and autoradiography. Simple techniques were found such that...

journal_title：Journal of cellular biochemistry

authors： Waygood EB,Mattoo RL,Peri KG

更新日期：1984-01-01 00:00:00

abstract：:Previously we have reported the production of a monoclonal antibody (Mab 1.2) which recognizes a cytoplasmic protein, terminin, in three different molecular weights: 90 (Tp90), 60 (Tp60), and 30 kDa (Tp30) forms. Further characterization shows that Tp90 is found in young growing and nongrowing quiescent fibroblasts, w...

journal_title：Journal of cellular biochemistry

authors： Wang E,Liu D

更新日期：1996-01-01 00:00:00

abstract：:Fgf10 has a prominent role in organogenesis. In the developing lung, Fgf10 is dynamically expressed in the distal mesenchyme from where it diffuses and activates its epithelial receptor, Fgfr2b, to trigger budding. Little is known about how Fgf10 expression is regulated. Here we have identified a mouse lung-specific m...

journal_title：Journal of cellular biochemistry

authors： Jean JC,Lü J,Joyce-Brady M,Cardoso WV

更新日期：2008-04-15 00:00:00

abstract：:For several decades, cholesterol has been thought to cause ASCVD. Limiting dietary cholesterol intake has been recommended to reduce the risk of the disease. However, several recent epidemiological studies do not support a relationship between dietary cholesterol and/or blood cholesterol and ASCVD. Consequently, the r...

journal_title：Journal of cellular biochemistry

authors： Huang SS,Liu IH,Chen CL,Chang JM,Johnson FE,Huang JS

更新日期：2017-06-01 00:00:00

abstract：:The bone marrow provides a protective environment for acute myeloid leukemia (AML) cells that often allows leukemic stem cells to survive standard chemotherapeutic regimens. Targeting these leukemic stem cells within the bone marrow is critical for preventing relapse. We recently demonstrated that SDF-1, a chemokine a...

journal_title：Journal of cellular biochemistry

authors： Kremer KN,Dudakovic A,McGee-Lawrence ME,Philips RL,Hess AD,Smith BD,van Wijnen AJ,Karp JE,Kaufmann SH,Westendorf JJ,Hedin KE

更新日期：2014-06-01 00:00:00

abstract：:The vitamin D receptor (VDR) binds to and mediates the effects of the 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) hormone to alter gene transcription. A newly recognized VDR ligand is the carcinogenic bile acid, lithocholic acid (LCA). We demonstrate that, in HT-29 colon cancer cells, both LCA and 1,25(OH)(2)D(3) ind...

journal_title：Journal of cellular biochemistry

authors： Jurutka PW,Thompson PD,Whitfield GK,Eichhorst KR,Hall N,Dominguez CE,Hsieh JC,Haussler CA,Haussler MR

更新日期：2005-04-01 00:00:00

abstract：:The aim of the present study was to test the hypothesis that the decreased renal tubular reabsorption of calcium observed in estrogen deficiency is associated with a local regulation of either PTHrP or PTH/PTHrP receptor genes in the kidney. Rats were randomly sham-operated (S) or ovariectomized receiving either vehic...

journal_title：Journal of cellular biochemistry

authors： Cros M,Silve C,Graulet AM,Morieux C,Ureña P,de Vernejoul MC,Bouizar Z

更新日期：1998-07-01 00:00:00

abstract：:Leptin is a protein involved in the regulation of food intake and in the immune and inflammatory responses, among other functions. Evidences demonstrate that obesity is directly associated with high levels of leptin, suggesting that leptin may directly link obesity with the elevated cardiovascular and renal risk assoc...

journal_title：Journal of cellular biochemistry

authors： Blanca AJ,Ruiz-Armenta MV,Zambrano S,Salsoso R,Miguel-Carrasco JL,Fortuño A,Revilla E,Mate A,Vázquez CM

更新日期：2016-10-01 00:00:00

abstract：:The role of estrogen receptor alpha (ERα) in breast cancer has been studied extensively, and its protein expression is prognostic and a primary determinant of endocrine sensitivity. However, much less is known about the role of ERβ and its relevance remains unclear due to the publication of conflicting reports. Here, ...

journal_title：Journal of cellular biochemistry

authors： Wu X,Subramaniam M,Negron V,Cicek M,Reynolds C,Lingle WL,Goetz MP,Ingle JN,Spelsberg TC,Hawse JR

更新日期：2012-02-01 00:00:00

abstract：:Conservative treatment for invasive bladder cancer (BC) involves a complete transurethral tumor resection combined with chemotherapy (CT) and radiotherapy (RT). The major obstacles of chemo-radiotherapy are the addition of the toxicities of RT and CT, and the recurrence due to RT and CT resistances. The flavonoid Sily...

journal_title：Journal of cellular biochemistry

authors： Prack Mc Cormick B,Langle Y,Belgorosky D,Vanzulli S,Balarino N,Sandes E,Eiján AM

更新日期：2018-07-01 00:00:00

abstract：:The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypothalamus by leptin. The hypothalamic extracellular signal-regulated kinase-1/2 (E...

journal_title：Journal of cellular biochemistry

authors： Gaspar RC,Muñoz VR,Kuga GK,Nakandakari SCBR,Minuzzi LG,Botezelli JD,da Silva ASR,Cintra DE,de Moura LP,Ropelle ER,Pauli JR

更新日期：2019-01-01 00:00:00

abstract：:Craniosynostosis is a condition in which some or all of the sutures in the skull of an infant close prematurely. Fibroblast growth factor receptor 2 (FGFR2) mutations are a well-known cause of craniosynostosis. Many syndromes that comprise craniosynostosis, such as Apert syndrome, Crouzon syndrome, and Pfeiffer syndro...

journal_title：Journal of cellular biochemistry

authors： Park J,Park OJ,Yoon WJ,Kim HJ,Choi KY,Cho TJ,Ryoo HM

更新日期：2012-02-01 00:00:00

abstract：:The deficiency of the enzyme glutaryl-CoA dehydrogenase, known as glutaric acidemia type I (GA-I), leads to the accumulation of glutaric acid (GA) and glutarilcarnitine (C5DC) in the tissues and body fluids, unleashing important neurotoxic effects. l-carnitine (l-car) is recommended for the treatment of GA-I, aiming t...

journal_title：Journal of cellular biochemistry

authors： Guerreiro G,Faverzani J,Jacques CED,Marchetti DP,Sitta A,de Moura Coelho D,Kayser A,Kok F,Athayde L,Manfredini V,Wajner M,Vargas CR

更新日期：2018-12-01 00:00:00

abstract：:This study aims to investigate how microRNA-375 (miR-375) improves immune function by regulating liver macrophages (Kupffer cells) in mice with liver failure. Forty mice were divided into ConA-1h, ConA-3h, ConA-6h, and control groups, with 10 mice in each group. Mice models of liver failure were established by injecti...

journal_title：Journal of cellular biochemistry

authors： Ke QH,Chen HY,He ZL,Lv Z,Xu XF,Qian YG,Zheng SS

更新日期：2019-01-01 00:00:00

abstract：:Cytology and cell biology are two separate fields that share a focus on cancer. Cancer is still diagnosed based on morphology, and surprisingly little is known about the molecular basis of the defining structural features. Cytology uses the smallest possible biopsy for diagnosis by reducing morphologic "criteria of ma...

journal_title：Journal of cellular biochemistry

authors： Fischer AH,Zhao C,Li QK,Gustafson KS,Eltoum IE,Tambouret R,Benstein B,Savaloja LC,Kulesza P

更新日期：2010-07-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs), via their interactions with numerous effector molecules such as FGF-2, IL-8, and VEGF, regulate the biological activity of cells by acting as co-receptors that promote signaling. The extent and nature of their role as co-receptors is often misregulated in cancer as manifested by ...

journal_title：Journal of cellular biochemistry

authors： Sanderson RD,Yang Y,Kelly T,MacLeod V,Dai Y,Theus A

更新日期：2005-12-01 00:00:00

abstract：:Bone is a target tissue of progestins, but the mechanisms by which they act are still unclear. We examined the early (5-60 s) effects of progesterone and progesterone covalently bound to BSA (P-CMO BSA), which does not enter the cell, on the cytosolic free Ca(2+) concentration ([Ca(2+)]i) and the formation of inositol...

journal_title：Journal of cellular biochemistry

authors： Grosse B,Kachkache M,Le Mellay V,Lieberherr M

更新日期：2000-08-02 00:00:00

abstract：:Arsenic is a well-known environmental toxicant but the mechanism by which it causes cytotoxicity is poorly understood. Arsenite induces apoptosis in glutathione (GSH)-deficient GCS-2 cells by causing cell cycle dysfunction and down-regulating critical signaling pathways. This study was designed to examine the effect o...

journal_title：Journal of cellular biochemistry

authors： Habib GM

更新日期：2010-05-15 00:00:00

abstract：:The caspase family of protease is speculated to have a crucial role in apoptosis. The effect of treatment with Idarubicin (IDA) and Medroxyprogesterone acetate (MPA), used alone or in combination, on the activation of Caspase-3 in canine Chronic Lymphatic Leukaemia (CLL) cells was investigated, in order to clarify the...

journal_title：Journal of cellular biochemistry

authors： Florio S,Crispino L,Ciarcia R,Vacca G,Pagnini U,de Matteis A,Pacilio C,D'Andrilli G,Kumar C,Giordano A

更新日期：2003-07-01 00:00:00

abstract：:Muscarinic acetylcholine receptors (mAChRs) regulate diverse cellular functions, including cell growth and proliferation, via multiple signaling pathways. Previously, we showed that mAChRs stimulate the MEK1/2-ERK1/2-RSK pathway in SNU-407 colon cancer cells and subsequently promote cell proliferation. In this study, ...

journal_title：Journal of cellular biochemistry

authors： Park YS,Liu Z,Vasamsetti BM,Cho NJ

更新日期：2016-12-01 00:00:00

abstract：:Adult stem cells are essential for tissue renewal, regeneration and repair, and their expansion in defined culture medium is on focus for regenerative medicine and genetic pathologies. The bone marrow has been shown to be very rich is pluripotent mesenchymal stem cells (MSCs) capable of forming bone, cartilage and als...

journal_title：Journal of cellular biochemistry

authors： Romero-Prado M,Blázquez C,Rodríguez-Navas C,Muñoz J,Guerrero I,Delgado-Baeza E,García-Ruiz JP

更新日期：2006-08-15 00:00:00

abstract：:Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95-2). Sorafenib induced cell death in EC cell...

journal_title：Journal of cellular biochemistry

authors： Sun NK,Huang SL,Chang TC,Chao CC

更新日期：2013-08-01 00:00:00

abstract：:Pancreatic stellate cells (PSCs) secrete various factors, which can influence the β-cell function. The identification of stellate cell infiltration into the islets in pancreatic diseases suggests possible existence of cross-talk between these cells. To elucidate the influence of PSCs on β-cell function, mouse PSCs wer...

journal_title：Journal of cellular biochemistry

authors： Bynigeri RR,Mitnala S,Talukdar R,Singh SS,Duvvuru NR

更新日期：2020-01-01 00:00:00