Down regulation of miR200c promotes radiation-induced thymic lymphoma by targeting BMI1.

abstract：:Enhanced phosphorylation of the ribosomal protein s6 kinase, p70(s6k), and the translational repressor, 4E-BP1, are associated with either insulin-induced or amino acid-induced protein synthesis. Hyperphosphorylation of p70(s6k) and 4E-BP1 in response to insulin or amino acids is mediated through the mammalian target ...

journal_title：Journal of cellular biochemistry

authors： Pham PT,Heydrick SJ,Fox HL,Kimball SR,Jefferson LS Jr,Lynch CJ

更新日期：2000-09-07 00:00:00

abstract：:We have cloned and sequenced a genomic DNA fragment of chicken containing a cluster of DNase I hypersensitive sites (DHS) located 11-15 kb upstream from the first gene of the alpha-globin gene domain and including a constitutive DHS flanked by two erythroid-specific ones. A 1.2-kb subfragment of the DNA fragment under...

journal_title：Journal of cellular biochemistry

authors： Razin SV,Shen K,Ioudinkova E,Scherrer K

更新日期：1999-07-01 00:00:00

abstract：:Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single agents, HDAC inhibitors may cause c...

journal_title：Journal of cellular biochemistry

authors： Marchion DC,Bicaku E,Daud AI,Richon V,Sullivan DM,Munster PN

更新日期：2004-05-15 00:00:00

abstract：:Bruton's tyrosine kinase (Btk) plays a crucial role in the maturation and differentiation of B-lymphocytes and immunoglobulin synthesis. Recently Btk has been described to be present in significant amount in human platelets. To investigate the regulation of this kinase in the platelets we studied its subcellular redis...

journal_title：Journal of cellular biochemistry

authors： Mukhopadhyay S,Ramars AS,Dash D

更新日期：2001-01-01 00:00:00

abstract：:Cellular differentiation is caused by highly controlled modifications in the gene expression but rarely involves a change in the DNA sequence itself. Histone acetylation is a major epigenetic factor that adds an acetyl group to histone proteins, thus altering their interaction with DNA and nuclear proteins. Illuminati...

journal_title：Journal of cellular biochemistry

authors： Tao H,Li Q,Lin Y,Zuo H,Cui Y,Chen S,Chen Z,Liu H

更新日期：2020-03-01 00:00:00

abstract：:The microenvironment of the cancer cell is pivotal to its phenotypic regulation. One of the central components of the microenvironment is temperature. An elevation in environmental temperature has been shown to increase the cancer cell's susceptibility to chemo- and radiation therapy. The goal of the studies described...

journal_title：Journal of cellular biochemistry

authors： Zeng Y,Kulkarni P,Inoue T,Getzenberg RH

更新日期：2009-05-01 00:00:00

abstract：:Androgen receptor (AR) signaling plays an important role in the development and progression of several liver diseases, including hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD). Dihydrotestosterone (DHT) is the active metabolite of the major circulating androgen, testosterone. In this stud...

journal_title：Journal of cellular biochemistry

authors： Dai R,Yan D,Li J,Chen S,Liu Y,Chen R,Duan C,Wei M,Li H,He T

更新日期：2012-05-01 00:00:00

abstract：:This study performed the first microarray analysis of long-noncoding RNA (lncRNA) and mRNA expression profiles in human steroid-induced avascular necrosis of the femoral head (SAVNFH). Expression levels of lncRNAs and mRNAs in three human SAVNFH samples and three human femoral head fracture samples (controls) were det...

journal_title：Journal of cellular biochemistry

authors： Luo H,Lan W,Li Y,Lian X,Zhang N,Lin X,Chen P

更新日期：2019-09-01 00:00:00

abstract：:A better understanding of breast cancer pathogenesis would contribute to improved diagnosis and therapy and potentially decreased mortality rates. Here, we found that the MORC family CW-type zinc finger 4 (MORC4) overexpression in breast cancer tissues is associated with poor survival, and the short-interfering RNA kn...

journal_title：Journal of cellular biochemistry

authors： Yang Z,Zhuang Q,Hu G,Geng S

更新日期：2019-03-01 00:00:00

abstract：:Osteosarcoma (OS) is the most malignant primary bone tumor in children and adolescents with limited treatment options and poor prognosis. Recently, aberrant expression of Runx2 has been found in OS, thereby contributing to the development, and progression of OS. However, the upstream signaling molecules that regulate ...

journal_title：Journal of cellular biochemistry

authors： Liang GH,Liu N,He MT,Yang J,Liang ZJ,Gao XJ,Rahhal AH,He QY,Zhang HT,Zha ZG

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been used in therapies for bone tissue healing. The aim of this study was to investigate the effect of cell source and osteoblast differentiation on gene expression profiles of MSCs from bone marrow (BM-MSCs) or adipose tissue (AT-MSCs) to contribute for selecting a suitable cell pop...

journal_title：Journal of cellular biochemistry

authors： Fideles SOM,Ortiz AC,Assis AF,Duarte MJ,Oliveira FS,Passos GA,Beloti MM,Rosa AL

更新日期：2019-02-11 00:00:00

abstract：:Occupational exposure to nickel has been epidemiologically linked to increased cancer risk in the respiratory tract. Nickel-induced cell transformation is associated with both genotoxic and epigenetic mechanisms that are poorly understood. Prolidase [E.C.3.4.13.9] is a cytosolic Mn(II)-activated metalloproteinase that...

journal_title：Journal of cellular biochemistry

authors： Miltyk W,Surazynski A,Kasprzak KS,Fivash MJ Jr,Buzard GS,Phang JM

更新日期：2005-04-15 00:00:00

abstract：BACKGROUND:MIAT may be implicated in the pathogenesis of age-related hearing loss (AHL). This study aimed to clarify the effect of a MIAT signaling pathway on the risk of AHL. METHODS:Terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, auditory brainstem response (ABR) and quantitative hair cell counts...

journal_title：Journal of cellular biochemistry

authors： Hao S,Wang L,Zhao K,Zhu X,Ye F

更新日期：2019-04-01 00:00:00

abstract：AIM:Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora flavescens Ait (the Chinese herb Kushen) and exhibits diverse pharmacological actions. In this study, we investigated the effects of OMT on diabetes-associated aortic endothelial dysfunction in a rat model of diabetes and its mec...

journal_title：Journal of cellular biochemistry

authors： Wang L,Li X,Zhang Y,Huang Y,Zhang Y,Ma Q

更新日期：2018-11-19 00:00:00

abstract：:The role of estrogen receptor alpha (ERα) in breast cancer has been studied extensively, and its protein expression is prognostic and a primary determinant of endocrine sensitivity. However, much less is known about the role of ERβ and its relevance remains unclear due to the publication of conflicting reports. Here, ...

journal_title：Journal of cellular biochemistry

authors： Wu X,Subramaniam M,Negron V,Cicek M,Reynolds C,Lingle WL,Goetz MP,Ingle JN,Spelsberg TC,Hawse JR

更新日期：2012-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short non-coding single-stranded RNAs, which play significant roles in the regulation of a myriad of biological processes. Overwhelmingly increasing high-impact research has also deepened our understanding about the central role of miRNAs in cancer development, metastatic spread, and development...

journal_title：Journal of cellular biochemistry

authors： Wen R,Umeano AC,Essegian DJ,Sabitaliyevich UY,Wang K,Farooqi AA

更新日期：2018-11-01 00:00:00

abstract：:ClC-3 chloride channel has been proved to have a relationship with the expression of osteogenic markers during osteogenesis, persistent static compression can upregulate the expression of ClC-3 and regulate osteodifferentiation in osteoblasts. However, there was no study about the relationship between the expression o...

journal_title：Journal of cellular biochemistry

authors： Wang D,Wang H,Gao F,Wang K,Dong F

更新日期：2017-06-01 00:00:00

abstract：:SIX5 is a member of the human SIX family of transcription factors, many of which are involved in eye development. However, SIX5 transcripts are known to be present at very low levels in cells and no study has yet convincingly demonstrated detection of endogenous SIX5 protein by Western blotting or immunolocalisation. ...

journal_title：Journal of cellular biochemistry

authors： Pham YC,Man Nt,Holt I,Sewry CA,Pall G,Johnson K,Morris GE

更新日期：2005-08-01 00:00:00

abstract：:Resistance to therapies, recurrence, and metastasis remain challenging issues for breast cancer patients, particularly for triple-negative and breast cancer stem cells. The activation of the epithelial-to-mesenchymal transition (EMT) plays an indispensable role in the poor prognosis of those types. The accumulating pr...

journal_title：Journal of cellular biochemistry

authors： Koohestanimobarhan S,Salami S,Imeni V,Mohammadi Z,Bayat O

更新日期：2018-09-06 00:00:00

abstract：:The activity of membrane-bound alkaline phosphatase (ALP) expressed on the external surface of cultured murine P19 teratocarcinoma and human HL-60 myeloblastic leukemia cells was studied at physiological pH using p-nitrophenylphosphate (pNPP) as substrate. The rate of substrate hydrolysis catalyzed by intact viable ce...

journal_title：Journal of cellular biochemistry

authors： Scheibe RJ,Kuehl H,Krautwald S,Meissner JD,Mueller WH

更新日期：2000-01-01 00:00:00

abstract：:The presented results show for the first time that the neurogenic transdifferentiation of hUC-MSCs considerably changes the elements of purinergic signaling profile. Although, it has been demonstrated in the literature that extracellular nucleotides and nucleosides determine the fate of mesenchymal and neural stem cel...

journal_title：Journal of cellular biochemistry

authors： Czarnecka J,Porowińska D,Bajek A,Hołysz M,Roszek K

更新日期：2017-03-01 00:00:00

abstract：:Paxillin is an adapter protein regulating signaling and focal adhesion assembly that has been linked to malignant potential in many malignancies. Overexpression of paxillin has been noted in aggressive tumors. Integrin-mediated binding through the focal adhesion complex is important in metastatic adhesion and is upreg...

journal_title：Journal of cellular biochemistry

authors： Conway WC,Van der Voort van Zyp J,Thamilselvan V,Walsh MF,Crowe DL,Basson MD

更新日期：2006-08-15 00:00:00

abstract：:We are interested in understanding the molecular events associated with the growth-arrest of vascular SMCs. We constructed a subtracted cDNA library enriched in nucleotide sequences associated with quiescent SMCs. This library was screened with similarly subtracted 32P-labeled cDNAs to identify growth-arrest associate...

journal_title：Journal of cellular biochemistry

authors： Ge L,Liau G

更新日期：1995-02-01 00:00:00

abstract：:Myelin basic protein (MBP) is a major component of the myelin sheath whose production is developmentally controlled during myelinogenesis. Earlier studies have indicated that programmed expression of the MBP gene is regulated at the level of transcription. Evidently, the MB1 regulatory motif located between nucleotide...

journal_title：Journal of cellular biochemistry

authors： Muralidharan V,Tretiakova A,Steplewski A,Haas S,Amini S,Johnson E,Khalili K

更新日期：1997-09-15 00:00:00

abstract：:Roscovitine (ROSC), a selective cyclin-dependent kinase (CDK) inhibitor, arrests human estrogen receptor-α (ER-α) positive MCF-7 breast cancer cells in the G(2) phase of the cell cycle and concomitantly induces apoptosis via a p53-dependent pathway. The effect of ROSC is markedly diminished in MCF-7 cells maintained i...

journal_title：Journal of cellular biochemistry

authors： Węsierska-Gądek J,Gritsch D,Zulehner N,Komina O,Maurer M

更新日期：2011-03-01 00:00:00

abstract：:The pathogenesis of hyperprolactinemia (hyperPRL) induced hypogonadism has been suggested to be related with a dysfunction of hypothalamus-pituitary-testis axis. While the direct inhibitory effects of prolactin (PRL) on testosterone (T) release have been demonstrated, the mechanism is still unclear. Our previous study...

journal_title：Journal of cellular biochemistry

authors： Huang WJ,Yeh JY,Kan SF,Chang LS,Wang PS

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Copy number variation (CNV) of DNA segments has been considered as an important component of genetic variation, affecting the quality and quantity of gene expression. Bone morphogenic protein 8A (BMP8A) has been reported to function in bone formation. With respect to the bone and joint complications in ankyl...

journal_title：Journal of cellular biochemistry

authors： Shahba S,Jafari Shakib R,Jamshidi A,Vojdanian M,Akhtari M,Aslani S,Poursani S,Nikokar I,Mahmoudi M

更新日期：2018-11-28 00:00:00

abstract：:Flavonoids are a group of naturally-occurring phenolic compounds in the plant kingdom, and many flavonoids are found with vascular protective properties. Nevertheless how the protective response is exerted by flavonoids is not well characterized. In view of the nuclear factor-kappaB (NFkappaB) may play a central role ...

journal_title：Journal of cellular biochemistry

authors： Tsai SH,Liang YC,Lin-Shiau SY,Lin JK

更新日期：1999-09-15 00:00:00

abstract：:Large osteoclasts (>or=10 nuclei) predominate at sites of pathological bone resorption. We hypothesized this was related to increased resorptive activity of large osteoclasts and have demonstrated previously that larger osteoclasts are 8-fold more likely to be resorbing than small osteoclasts (2-5 nuclei). Here we ask...

journal_title：Journal of cellular biochemistry

authors： Trebec DP,Chandra D,Gramoun A,Li K,Heersche JN,Manolson MF

更新日期：2007-05-01 00:00:00

abstract：:The following thiol-containing peptide analogues of the carboxyl side of the collagenase-sensitive bond of collagen were synthesized and tested as inhibitors of collagenases partially purified from homogenates of rabbit V-2 tumor and culture medium of pig synovium: HSCH2CH(CH3)CO-Ala-OEt (I), HSCH2CH(CH2Ph)CO-Ala-OEt ...

journal_title：Journal of cellular biochemistry

authors： Gray RD,Miller RB,Spatola AF

更新日期：1986-01-01 00:00:00