Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3β-dependent protein degradation.

abstract：:Colorectal cancer (CRC) is known as the third most common and fourth leading cancer associated death worldwide. The occurrence of metastasis has remained as a critical challenge in CRC, so that distant metastasis (mostly to the liver) has been manifested in about 20%-25% of patients. Several screening approaches have ...

journal_title：Journal of cellular biochemistry

authors： Sarvizadeh M,Ghasemi F,Tavakoli F,Sadat Khatami S,Razi E,Sharifi H,Biouki NM,Taghizadeh M

更新日期：2019-06-01 00:00:00

abstract：:Atherosclerosis and related cardiovascular diseases (CVD) represent one of the greatest threats to human health worldwide. The protection of vascular smooth muscle cells (VSMCs) from apoptosis in the plaque has become an important therapeutic target for atherosclerotic plaque stabilization. A significant association o...

journal_title：Journal of cellular biochemistry

authors： Ye Y,Fu F,Li X,Yang J,Liu H

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Long intergenic noncoding RNA-p21 (lincRNA-p21) has been proved in the pathogenesis of aortic aneurysms, while its functionality in thoracic aortic aneurysms (TAA) and the mechanism of function remains unclear. Therefore our study aimed to investigate the role of lincRNA-p21 in TAA. METHODS:Aortic media spec...

journal_title：Journal of cellular biochemistry

authors： Hu W,Wang Z,Li Q,Wang J,Li L,Jiang G

更新日期：2019-03-01 00:00:00

abstract：:Malignant gliomas, the most common subtype of primary brain tumors, are characterized by high proliferation, great invasion, and neurological destruction and considered to be the deadliest of human cancers. Analgesic-antitumor peptide (AGAP), one of scorpion toxic polypeptides, has been shown to have antitumor activit...

journal_title：Journal of cellular biochemistry

authors： Zhao Y,Cai X,Ye T,Huo J,Liu C,Zhang S,Cao P

更新日期：2011-09-01 00:00:00

abstract：:The caspase family of protease is speculated to have a crucial role in apoptosis. The effect of treatment with Idarubicin (IDA) and Medroxyprogesterone acetate (MPA), used alone or in combination, on the activation of Caspase-3 in canine Chronic Lymphatic Leukaemia (CLL) cells was investigated, in order to clarify the...

journal_title：Journal of cellular biochemistry

authors： Florio S,Crispino L,Ciarcia R,Vacca G,Pagnini U,de Matteis A,Pacilio C,D'Andrilli G,Kumar C,Giordano A

更新日期：2003-07-01 00:00:00

abstract：:Photodynamic treatment is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with activation of a photosensitizer agent at a specific light. Little is known, however, about the phototoxic properties of curcumin, as a natural phenolic compound, against different types of can...

journal_title：Journal of cellular biochemistry

authors： Khorsandi K,Hosseinzadeh R,Shahidi FK

更新日期：2019-04-01 00:00:00

abstract：:The cellular distribution and nature of proteoglycans synthesised by human breast cancer cells in culture were studied. Proteoglycans were labelled with [35S] sulfate, purified, and characterised after ion-exchange chromatography followed by gel-filtration chromatography and treatment with glycosaminoglycan degrading ...

journal_title：Journal of cellular biochemistry

authors： Delehedde M,Deudon E,Boilly B,Hondermarck H

更新日期：1997-03-15 00:00:00

abstract：:The contribution of proximal tubules (PT) to albumin uptake is now well recognized, however, its regulation is understudied area. There are reports suggesting that insulin resistance is associated with the development of albuminuria in nondiabetic individuals. We have previously reported reduced insulin receptor (IR) ...

journal_title：Journal of cellular biochemistry

authors： Kumari M,Sharma R,Pandey G,Ecelbarger CM,Mishra P,Tiwari S

更新日期：2019-06-01 00:00:00

abstract：:Magnolol, a substance purified from the bark of Magnolia officialis, inhibits cell proliferation and induces apoptosis in a variety of cancer cells. The aim of this study was to study the effects of magnolol on CGTH W-2 thyroid carcinoma cells. After 24 h treatment with 80 microM magnolol in serum-containing medium, a...

journal_title：Journal of cellular biochemistry

authors： Huang SH,Chen Y,Tung PY,Wu JC,Chen KH,Wu JM,Wang SM

更新日期：2007-07-01 00:00:00

abstract：:Cancer of the ovary is the leading cause of death from gynecologic malignancy. To understand better these aggressive tumors, the development of in vitro models to study human ovarian cancer is critical. However, the establishment of long-term cell lines has been difficult, due to the generalized poor survival of patie...

journal_title：Journal of cellular biochemistry

authors： Becker JL,Prewett TL,Spaulding GF,Goodwin TJ

更新日期：1993-03-01 00:00:00

abstract：:The cleavage of poliovirus precursor polypeptides occurs at specific amino acid pairs that are recognized by viral proteinases. Most of the polio-specific cleavages occur at glutamine-glycine (Q-G) pairs that are recognized by the viral-encoded proteinase 3C (formerly called P3-7c). In order to carry out a defined mol...

journal_title：Journal of cellular biochemistry

authors： Semler BL,Johnson VH,Dewalt PG,Ypma-Wong MF

更新日期：1987-01-01 00:00:00

abstract：:New perinatal care technologies have improved the survival rate of preterm neonates, but the prevalence of bronchopulmonary dysplasia (BPD), one of the most intractable problems in neonatal intensive care unit (NICU), remains unchanged. In present study, high-throughput sequencing (HTS) was performed to detect the exp...

journal_title：Journal of cellular biochemistry

authors： Wang J,Yin J,Wang X,Liu H,Hu Y,Yan X,Zhuang B,Yu Z,Han S

更新日期：2019-06-01 00:00:00

abstract：:To ascertain whether p53 deficiency in vivo leads to the deregulation of DNA methylation machinery prior to tumor development, we investigated the expression profile of DNA methyltransferases in the thymus and the liver of p53(+/+), p53(+/-), and p53(-/-) mice at 7 weeks of age before tumor development. The expression...

journal_title：Journal of cellular biochemistry

authors： Park IY,Sohn BH,Choo JH,Joe CO,Seong JK,Lee YI,Chung JH

更新日期：2005-02-15 00:00:00

abstract：:The lysosomal cysteine protease cathepsin B is implicated in degradation of extracellular matrix (ECM), a crucial step in a variety of physiological and pathological processes, including tumor dissemination and angiogenesis. In this study, we analyzed the contribution of extracellular and intracellular cathepsin B act...

journal_title：Journal of cellular biochemistry

authors： Premzl A,Turk V,Kos J

更新日期：2006-04-15 00:00:00

abstract：:The myelin basic protein (MBP)-phosphorylating enzymes present during maturation and early embryogenesis of the sea star (Pisaster ochraceus) were investigated. The major maturation-activated MBP kinase (p45 Mapk) was molecularly cloned based on tryptic sequence information obtained with the purified enzyme and shown ...

journal_title：Journal of cellular biochemistry

authors： Lefebvre DL,Charest DL,Yee A,Crawford BJ,Pelech SL

更新日期：1999-11-01 00:00:00

abstract：:Circular RNA (circRNA) has been reported to have great scientific significance and clinical value in multiple cancers including colorectal cancer (CRC). However, the biological function of most circRNAs in CRC is still in its infancy. Herein, we discovered the differential expressed circRNAs (DECs) between CRC tissues...

journal_title：Journal of cellular biochemistry

authors： Xu D,Wu Y,Wang X,Hu X,Qin W,Li Y,Wang Y,Zhang Z,Lu S,Sun T,Wu Z,Fu D,Fu B,Zhang J,Chen Q,Wei M,Zhao L,Wu H

更新日期：2020-03-01 00:00:00

abstract：:Although, the precise host defence mechanism(s) is not completely understood, T cell-mediated immune responses is believed to play a pivotal role in controlling parasite infection. Here we target the stage dependent over expressed gene. Here, the consensus based computational approach was adopted for the screening of ...

journal_title：Journal of cellular biochemistry

authors： Dikhit MR,Vijayamahantesh.,Kumar A,Amit A,Dehury B,Nathsharma YP,Ansari MY,Ali V,Topno RK,Das V,Pandey K,Sahoo GC,Bimal S,Das P

更新日期：2018-01-01 00:00:00

abstract：:Thrombin is a potent mitogen for human vascular smooth muscle cells (HVSMC) and its enzymatic activity is required for this function. The present study demonstrates that prothrombin is also mitogenic for HVSMC due to the generation of enzymatically active thrombin which occurs upon incubation of prothrombin with the c...

journal_title：Journal of cellular biochemistry

authors： Benzakour O,Kanthou C,Lupu F,Dennehy U,Goodwin C,Scully MF,Kakkar VV,Cooper DN

更新日期：1995-12-01 00:00:00

abstract：:Taxol, a microtubule stabilizing agent, has been extensively investigated for its antitumor activity. The cytotoxic effect of taxol is generally attributed to its antimicrotubule activity and is believed to be cell cycle dependent. Herein, we report that taxol induces hyperphosphorylation and reorganization of the vim...

journal_title：Journal of cellular biochemistry

authors： Chu JJ,Chen KD,Lin YL,Fei CY,Chiang AS,Chiang CD,Lai YK

更新日期：1998-03-15 00:00:00

abstract：:The expression of STRO-1, the essential mesenchymal stem cell marker, was found to decrease with advancing passages in few tissues. Because STRO-1 was identified and isolated from human gingiva, we were interested to know its status after a few passages. Human gingival mesenchymal stem cells (HGMSCs) were isolated fro...

journal_title：Journal of cellular biochemistry

authors： Ranga Rao S,Subbarayan R

更新日期：2019-03-01 00:00:00

abstract：:Two monoclonal antibodies that cause changes in the morphology of cultured myogenic cells are described. Antibody JG9 causes myoblasts to round up and causes myotubes to become thin, cable-like structures with multiple round swellings. Antibody JG22 causes both myoblasts and myotubes to become round refractile cells p...

journal_title：Journal of cellular biochemistry

authors： Greve JM,Gottlieb DI

更新日期：1982-01-01 00:00:00

abstract：:Lysyl oxidase (LO) plays a critical role in the formation and repair of the extracellular matrix (ECM) by oxidizing lysine residues in elastin and collagen, thereby initiating the formation of covalent crosslinkages which stabilize these fibrous proteins. Its catalytic activity depends upon both its copper cofactor an...

journal_title：Journal of cellular biochemistry

authors： Kagan HM,Li W

更新日期：2003-03-01 00:00:00

abstract：:The lining of the trachea consists of a pseudostratified, mucociliary epithelium that under a variety of conditions, such as vitamin A deficiency, toxic and mechanical injury, becomes a stratified squamous epithelium. Several in vitro cell culture models have been established to study the process of differentiation of...

journal_title：Journal of cellular biochemistry

authors： Kim YS,Hwang SM,Lee SJ,Jung JS

更新日期：2002-01-01 00:00:00

abstract：:In this experiment, the cross-talk betweenNotch and the NF-κB signaling pathway was examined to reveal the mechanism of slowing down the type II collagen (ColII) and aggrecan degeneration affected by inflammatory cytokines. The expression levels of ColII and aggrecan in the intervertebral disc were observed through im...

journal_title：Journal of cellular biochemistry

authors： Huang Y,Mei W,Chen J,Jiang T,Zhou Z,Yin G,Fan J

更新日期：2018-10-26 00:00:00

abstract：:Procyanidins have been associated with a reduced risk of cardiovascular diseases such as atherosclerosis. However, the molecular mechanisms underlying this benefit are not fully understood. Increased reactive oxygen species (ROS) production generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is a ...

journal_title：Journal of cellular biochemistry

authors： Álvarez E,Rodiño-Janeiro BK,Jerez M,Ucieda-Somoza R,Núñez MJ,González-Juanatey JR

更新日期：2012-04-01 00:00:00

abstract：:Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are clinical emergencies with no effective pharmaceutical treatment. This study aims to determine the protective effects of Nrf2-transfected human amniotic mesenchymal stem cells (hAMSCs) against lipopolysaccharide (LPS)-induced lung injury in mice...

journal_title：Journal of cellular biochemistry

authors： Zhang S,Jiang W,Ma L,Liu Y,Zhang X,Wang S

更新日期：2018-02-01 00:00:00

abstract：:Currently, traditional predictors of prognosis (tumor size, nodal status, progesterone receptor [PR], estrogen receptor [ER], or human epidermal growth factor receptor-2 [HER2]) are insufficient for precise survival prediction for triple-negative breast cancer (TNBC). Long noncoding RNAs (lncRNAs) have been observed t...

journal_title：Journal of cellular biochemistry

authors： Fan CN,Ma L,Liu N

更新日期：2019-03-01 00:00:00

abstract：:Loss of mechanical stress causes bone loss. However, the mechanisms underlying the unloading-induced bone loss are largely unknown. Here, we examined the effects of gold-thioglucose (GTG) treatment, which destroys ventromedial hypothalamus (VMH), on unloading-induced bone loss. Unloading reduced bone volume in control...

journal_title：Journal of cellular biochemistry

authors： Hino K,Nifuji A,Morinobu M,Tsuji K,Ezura Y,Nakashima K,Yamamoto H,Noda M

更新日期：2006-10-15 00:00:00

abstract：:Conservative treatment for invasive bladder cancer (BC) involves a complete transurethral tumor resection combined with chemotherapy (CT) and radiotherapy (RT). The major obstacles of chemo-radiotherapy are the addition of the toxicities of RT and CT, and the recurrence due to RT and CT resistances. The flavonoid Sily...

journal_title：Journal of cellular biochemistry

authors： Prack Mc Cormick B,Langle Y,Belgorosky D,Vanzulli S,Balarino N,Sandes E,Eiján AM

更新日期：2018-07-01 00:00:00

abstract：:In a previous work, taking advantage of the gene-array screening technology, we analysed the effects of histone deacetylase (HDAC) inhibitor sodium butyrate (NaBt), on gene transcription in HT29 human adenocarcinoma cell line. In this study, we focused our attention on p55CDC/Cdc20 gene, whose expression was dramatica...

journal_title：Journal of cellular biochemistry

authors： Iacomino G,Medici MC,Napoli D,Russo GL

更新日期：2006-11-01 00:00:00