LncRNA MALAT1 promotes oxidized low-density lipoprotein-induced autophagy in HUVECs by inhibiting the PI3K/AKT pathway.


:Emerging evidence suggests that long noncoding RNAs (lncRNAs) are involved in many biological processes, such as cell growth, differentiation, apoptosis, and autophagy. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), highly expressed in endothelial cells, is well conserved and implicated in endothelial cell migration and proliferation. However, whether MALAT1 participates in oxidized low-density lipoprotein (ox-LDL)-induced autophagy regulation in human umbilical vein endothelial cells (HUVECs) remains unknown. In this study, we observed that autophagy was upregulated and MALAT1 expression was markedly increased in HUVECs treated with ox-LDL. The ox-LDL-induced autophagy of HUVECs is significantly associated with the PI3K/AKT pathway. Furthermore, we found that MALAT1 overexpression inhibited PI3K, Akt and p70S6K phosphorylation and downregulated RHEB expression, simultaneously increasing ox-LDL-induced autophagy. MALAT1 silencing caused higher phosphorylated PI3K, Akt and p70S6K levels, upregulated RHEB expression and markedly suppressed autophagy. These results indicated that lncRNA MALAT1 promotes ox-LDL-induced autophagy in HUVECs partly through the PI3K/AKT signaling pathway.


J Cell Biochem


Li S,Pan X,Yang S,Ma A,Yin S,Dong Y,Pei H,Bi X,Li W




Has Abstract


2019-03-01 00:00:00












  • Leptin and connective tissue growth factor in advanced glycation end-product-induced effects in NRK-49F cells.

    abstract::Previously, we showed that Janus kinase 2 (JAK2) is important in advanced glycation end-product (AGE)-induced effects in renal interstitial (NRK-49F) fibroblasts. Leptin is a JAK2-activating cytokine via the long form leptin receptor (Ob-Rb). Leptin and connective tissue growth factor (CTGF) may be involved in renal f...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lee CI,Guh JY,Chen HC,Lin KH,Yang YL,Hung WC,Lai YH,Chuang LY

    更新日期:2004-11-15 00:00:00

  • An intranuclear frame for chromatin compartmentalization and higher-order folding.

    abstract::Recent ultrastructural, immunoelectron, and confocal microscopy observations done in our laboratory [Barboro et al. [2002] Exp. Cell. Res. 279:202-218] have confirmed that lamins and the nuclear mitotic apparatus protein (NuMA) are localized inside the interphase nucleus in a polymerized form. This provided evidence o...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Barboro P,D'Arrigo C,Mormino M,Coradeghini R,Parodi S,Patrone E,Balbi C

    更新日期:2003-01-01 00:00:00

  • Interleukin-1beta induces osteopontin expression in pulmonary fibroblasts.

    abstract::Osteopontin is a multifunctional matricellular protein identified as one of the most upregulated genes in pulmonary fibrosis. Experimental animal models have identified early pro-fibrotic cytokines as essential to the pathogenesis of inflammation-induced pulmonary fibrosis. However, the principal sources of osteoponti...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Serlin DM,Kuang PP,Subramanian M,O'Regan A,Li X,Berman JS,Goldstein RH

    更新日期:2006-02-15 00:00:00

  • Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo.

    abstract::Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead to better treatment strategies. The chemokine stromal-derived factor-1 (SDF-1 or CXCL12) and its...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sun YX,Wang J,Shelburne CE,Lopatin DE,Chinnaiyan AM,Rubin MA,Pienta KJ,Taichman RS

    更新日期:2003-06-01 00:00:00

  • Arsenite causes down-regulation of Akt and c-Fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells.

    abstract::Arsenic is a well-known environmental toxicant but the mechanism by which it causes cytotoxicity is poorly understood. Arsenite induces apoptosis in glutathione (GSH)-deficient GCS-2 cells by causing cell cycle dysfunction and down-regulating critical signaling pathways. This study was designed to examine the effect o...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Habib GM

    更新日期:2010-05-15 00:00:00

  • Prosaposin is a novel androgen-regulated gene in prostate cancer cell line LNCaP.

    abstract::Androgen-regulated genes (ARG) are implicated in normal and neoplastic growth of the prostate. Recently, we reported genomic amplification and/or overexpression of a previously known neurotrophic factor, prosaposin, in androgen-independent (AI) or metastatic prostate cancer (PCa) cells and tissues. Prosaposin and/or i...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Koochekpour S,Lee TJ,Wang R,Sun Y,Delorme N,Hiraiwa M,Grabowski GA,Culig Z,Minokadeh A

    更新日期:2007-06-01 00:00:00

  • The role of membrane lectins in Dictyostelium discoideum aggregation as ascertained by specific univalent antibodies against discoidin I.

    abstract::Antibodies against pure discoidin I have been used as a tool to ascertain the role of this lectin in aggregation of Dictyostelium discoideum. Discoidin I is widely expressed over the cell surface of aggregation-competent AX-2 cells, as ascertained by indirect immunofluorescence with specific (antidiscoidin I) antibodi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Cano A,Pestaña A

    更新日期:1984-01-01 00:00:00

  • Ebselen inhibits the activity of acetylcholinesterase globular isoform G4 in vitro and attenuates scopolamine-induced amnesia in mice.

    abstract::There is a well-known relationship between the cholinergic system and learning, memory, and other common cognitive processes. The process for researching and developing new drugs has lead researchers to repurpose older ones. This study investigated the effects of ebselen on the activity of acethylcholinesterase (AChE)...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Martini F,Pesarico AP,Brüning CA,Zeni G,Nogueira CW

    更新日期:2018-07-01 00:00:00

  • NS5ATP9 Promotes Beclin 1-Dependent Starvation-Induced Autophagy of Hepatoblastoma Cells.

    abstract::NS5ATP9, a gene up-regulated by NS5A, plays a crucial oncogenic role in several types of human tumours. However, the underlying mechanisms remain unclear. Autophagy, an evolutionarily conserved catabolic process, maintains cellular homeostasis under stress conditions, such as starvation, and plays a crucial role in tu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Quan M,Liu S,Wang Q,Li G,Zhang Y,Feng S,Liang J,Cheng J

    更新日期:2015-08-01 00:00:00

  • 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-glucoside eliminates ischemia/reperfusion injury-induced H9c2 cardiomyocytes apoptosis involving in Bcl-2, Bax, caspase-3, and Akt activation.

    abstract:OBJECTIVE:This study was designed to explore the protective effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against ischemia/reperfusion (I/R) injury-induced cardiomyocytes apoptosis. METHODS:The H9c2 cell I/R injury model was induced by simultaneous shortage of nutrients and oxygen. TSG administration...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sun T,Liu H,Cheng Y,Yan L,Krittanawong C,Li S,Qian W,Su W,Chen X,Hou X,Zhang H

    更新日期:2019-03-19 00:00:00

  • Knockdown of LncRNA-UCA1 suppresses chemoresistance of pediatric AML by inhibiting glycolysis through the microRNA-125a/hexokinase 2 pathway.

    abstract::Dysregulation of lncRNAs is implicated in chemoresistance in varieties of tumor including acute myeloid leukemia (AML). LncRNA urothelial carcinoma-associated 1 (UCA1) was reported to play an oncogenic role in AML. However, whether UCA1 was involved in chemoresistance in pediatric AML remains unclear. UCA1 expression ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhang Y,Liu Y,Xu X

    更新日期:2018-07-01 00:00:00

  • Identification of Key Gene Modules of Neuropathic Pain by Co-Expression Analysis.

    abstract::Neuropathic pain (NP) is a substantial clinical problem causing great injury to people word-widely. Although gene expression analyses had been performed previously, the mechanisms underlying the etiology and development of NP are still poorly understood. To understand the function genes involved in the etiology and de...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhang Y,Wang J,Ji LJ,Li L,Wei M,Zhen S,Wen CC

    更新日期:2017-12-01 00:00:00

  • Inhibition of Endoplasmic Reticulum Stress Apoptosis by Estrogen Protects Human Umbilical Vein Endothelial Cells Through the PI3 Kinase-Akt Signaling Pathway.

    abstract::We aimed to investigate whether the cardioprotective effect of estrogen is mediated by inhibiting the apoptosis induced by endoplasmic reticulum stress (ERS) and to explore the underlying signaling pathway responsible for this effect. The effect of estrogen on ERS apoptosis, the mechanism responsible for that effect, ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Su Q,Wang Y,Yang X,Li XD,Qi YF,He XJ,Wang YJ

    更新日期:2017-12-01 00:00:00

  • Inorganic phosphate as a signaling molecule in osteoblast differentiation.

    abstract::The spatial and temporal coordination of the many events required for osteogenic cells to create a mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product, demand that these cells have mechanisms to carefully monitor events in the extracellular environment ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Beck GR Jr

    更新日期:2003-10-01 00:00:00

  • LncRNA CRNDE promotes hepatocellular carcinoma progression by upregulating SIX1 through modulating miR-337-3p.

    abstract:BACKGROUND:Long noncoding RNA (lncRNA) is emerging as a vital regulator in various cancers. Recently, it was found that lncRNA colorectal neoplasia differentially expressed (CRNDE) plays an oncogenic role, promoting cell proliferation and migration in hepatocellular carcinoma (HCC). However, the underlying regulatory m...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Tang D,Zhao L,Peng C,Ran K,Mu R,Ao Y

    更新日期:2019-09-01 00:00:00

  • Stem cell-based cell therapy for neuroprotection in stroke: A review.

    abstract::Neurological disorders, such as stroke, are triggered by a loss of neurons and glial cells. Ischemic stroke remains a substantial problem for industrialized countries. Over the previous few decades our understanding about the pathophysiology of stroke has enhanced, nevertheless, more awareness is required to advance t...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Rikhtegar R,Yousefi M,Dolati S,Kasmaei HD,Charsouei S,Nouri M,Shakouri SK

    更新日期:2019-06-01 00:00:00

  • Integrin alpha V beta 3 targeted dendrimer-rapamycin conjugate reduces fibroblast-mediated prostate tumor progression and metastasis.

    abstract::Therapeutic strategies targeting both cancer cells and associated cells in the tumor microenvironment offer significant promise in cancer therapy. We previously reported that generation 5 (G5) dendrimers conjugated with cyclic-RGD peptides target cells expressing integrin alpha V beta 3. In this study, we report a nov...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hill EE,Kim JK,Jung Y,Neeley CK,Pienta KJ,Taichman RS,Nor JE,Baker JR Jr,Krebsbach PH

    更新日期:2018-11-01 00:00:00

  • Broader utilization of origins of DNA replication in cancer cell lines along a 78 kb region of human chromosome 2q34.

    abstract::Human DNA replication depends on the activation of thousands of origins distributed within the genome. The actual distribution of origins is not known, nor whether this distribution is unique to a cell type, or if it changes with the proliferative state of the cell. In this study, we have employed a real-time PCR-base...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Valenzuela MS,Hu L,Lueders J,Walker R,Meltzer PS

    更新日期:2012-01-01 00:00:00

  • The effects of peptides with estrogen-like activity on cell proliferation and energy metabolism in human derived vascular smooth muscle cells.

    abstract::Hormone replacement therapy (HRT) for post-menopausal symptoms in diabetes is associated with increased risk of coronary heart disease and stroke. Therefore, there is a need for new HRT with no adverse effects on diabetic post-menopausal women. We developed peptides as potential estrogen mimetic compounds and now we e...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Somjen D,Knoll E,Gayer B,Kasher R,Kohen F,Stern N

    更新日期:2010-08-01 00:00:00

  • Functional interrelationships between nuclear structure and transcriptional control: contributions to regulation of cell cycle- and tissue-specific gene expression.

    abstract::Multiple levels of nuclear structure contribute to functional interrelationships with transcriptional control in vivo. The linear organization of gene regulatory sequences is necessary but insufficient to accommodate the requirements for physiological responsiveness to homeostatic, developmental, and tissue-related si...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


    authors: Stein GS,Stein JL,Lian JB,van Wijnen AJ,Montecino M

    更新日期:1996-08-01 00:00:00

  • Saitohin, which is nested within the tau gene, interacts with tau and Abl and its human-specific allele influences Abl phosphorylation.

    abstract::Saitohin (STH) is a gene unique to humans and their closest relatives whose function is not yet known. STH contains a single polymorphism (Q7R); the Q allele is human-specific and confers susceptibility to several neurodegenerative diseases. In previous work, we discovered that STH interacts with Peroxiredoxin 6 (Prdx...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wang Y,Gao L,Conrad CG,Andreadis A

    更新日期:2011-11-01 00:00:00

  • Prior Exercise Training Prevent Hyperglycemia in STZ Mice by Increasing Hepatic Glycogen and Mitochondrial Function on Skeletal Muscle.

    abstract::Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. We investigated the effect of a prior 30 days voluntary exercise protocol on STZ-diabetic CF1 mice. Glycemia, and the liver and skeletal muscle glycogen, mitochondrial function, and redox status were analyzed up to 5 days after STZ injection. An...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: de Carvalho AK,da Silva S,Serafini E,de Souza DR,Farias HR,de Bem Silveira G,Silveira PC,de Souza CT,Portela LV,Muller AP

    更新日期:2017-04-01 00:00:00

  • Involvement of STIM1 in the proteinase-activated receptor 1-mediated Ca2+ influx in vascular endothelial cells.

    abstract::Thrombin increases the cytosolic Ca(2+) concentrations and induces NO production by activating proteinase-activated receptor 1 (PAR(1)) in vascular endothelial cells. The store-operated Ca(2+) influx is a major Ca(2+) influx pathway in non-excitable cells including endothelial cells and it has been reported to play a ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Hirano K,Hirano M,Hanada A

    更新日期:2009-10-01 00:00:00

  • MicroRNA and exosome: Key players in rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA) is known as one of important autoimmune disorders which can lead to joint pain and damage throughout body. Given that internal (ie, genetic and epigenetic alterations) and external factors (ie, lifestyle changes, age, hormones, smoking, stress, and obesity) involved in RA pathogenesis. Increa...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zakeri Z,Salmaninejad A,Hosseini N,Shahbakhsh Y,Fadaee E,Shahrzad MK,Fadaei S

    更新日期:2019-03-01 00:00:00

  • miR-200a mediates protection of thymosin β-4 in cardiac microvascular endothelial cells as a novel mechanism under hypoxia-reoxygenation injury.

    abstract::Thymosin β-4 (Tβ4) is a ubiquitous protein, which has been suggested to regulate multiple cell signal pathways and a variety of cellular functions. However, the role Tβ4 plays in the cardiac microvascular endothelial cells (CMECs) under myocardial ischemia/reperfusion injury is currently unknown. Here we investigated ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Li Y,Zhu X,Liu X,Du A,Yu B

    更新日期:2019-11-01 00:00:00

  • Soluble 80-kd fragment of cell-CAM 120/80 disrupts cell-cell adhesion.

    abstract::Calcium-dependent cell adhesion molecules (CAMs) mediate intercellular adhesion in epithelial cells and in preimplantation mammalian embryos. One of these molecules, cell-CAM 120/80, is found on cells as a 120-kd membrane glycoprotein and as a soluble 80-kd species in conditioned culture medium [Damsky et al: Cell 34:...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Wheelock MJ,Buck CA,Bechtol KB,Damsky CH

    更新日期:1987-07-01 00:00:00

  • The activity of aminoacyl-tRNA synthetase-interacting multi-functional protein 1 (AIMP1) on endothelial cells is mediated by the assembly of a cytoskeletal protein complex.

    abstract::AIMP1 was first found as a factor associated with the aminoacyl-tRNA synthetase (ARS) complex. However, it is also secreted and acts on different target cells such as endothelial cells, macrophages, and fibroblasts as an extracellular regulator, respectively, of angiogenesis, inflammatory responses and dermal regenera...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Jackson VC,Dewilde S,Albo AG,Lis K,Corpillo D,Canepa B

    更新日期:2011-07-01 00:00:00

  • Phosphatidylcholine-specific phospholipase C and ROS were involved in chicken blastodisc differentiation to vascular endothelial cells.

    abstract::To find the key factors that were involved in the survival and vascular endothelial differentiation of chick blatodisc induced by fibroblast growth factor 2 (FGF-2), we built a chick vasculogenesis model in vitro. Subsequently, the activities of phosphatidylcholine-specific phospholipase C (PC-PLC), including Ca(2+)-d...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Zhao J,Zhao B,Wang W,Huang B,Zhang S,Miao J

    更新日期:2007-10-01 00:00:00

  • Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation.

    abstract::Strong activation of the ERK signal is required for hepatocyte growth factor (HGF) to inhibit proliferation of the human hepatocellular carcinoma cell line HepG2. However, it is still to be elucidated whether the activation alone is sufficient to induce the inhibitory effect. In this study, we constructed HepG2 cell c...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Shirako E,Hirayama N,Tsukada Y,Tanaka T,Kitamura N

    更新日期:2008-05-01 00:00:00

  • Overexpression of FOXS1 in gastric cancer cell lines inhibits proliferation, metastasis, and epithelial-mesenchymal transition of tumor through downregulating wnt/β-catenin pathway.

    abstract:BACKGROUND:Expression of forkhead box (FOX) superfamily members has been shown to be decreased in cancer, which was linked to poor prognosis of patients. The aim of this study was to investigate the expression of a new FOX superfamily member, FOXS1, in gastric cancer, and the influence of FOXS1 overexpression on the tu...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lu Q,Ma X,Li Y,Song W,Zhang L,Shu Y,Wan B

    更新日期:2019-03-01 00:00:00