Prognostic factors of budesonide therapy for the management of Crohn's disease: A meta-analysis.


BACKGROUND:This study aimed to identify factors that affect the prognosis of budesonide therapy for Crohn's disease patients. METHOD:Change in Crohn's disease activity index (CDAI) scores at latest follow-up after budesonide therapy reported by individual studies were pooled to gain overall effect size under random effects model and then metaregression analyses were performed to identify factors affecting the change in CDAI scores after budesonide treatment. RESULTS:Fifteen studies (1875 patients; age, 35.6 years [95% confidence interval (CI): 34.1, 37.0]; 41.66% [95% CI: 37.44, 45.88] males; 33.3% [95% CI: 24.3, 42.3] smokers; weight, 64.7 kg [95% CI: 62.71 66.6] and height, 168 cm [95% CI: 165, 171]) were included. Disease duration was 7.0 years [95% CI: 5.7, 8.2] and duration of the current episode was 3.1 months [95% CI: 1.7, 4.4]. Proportion of patients with prior resection was 42% [95% CI: 34%, 50%]. The disease was 21% in the ileum, 61% in ileocecum, and 18% in the colon. Budesonide dose was 8.83 mg/d [95% CI: 7.52, 10.14]. In a follow-up duration of 21.0 weeks [95% CI: 15.2, 26.8], budesonide treatment was associated with improvement in CDAI score of -117.8 [95% CI: -134.0, -102.0]. The magnitude of the change in CDAI score at the latest follow-up was significantly inversely associated with the percentage of smokers, but positively associated with the baseline CDAI score and duration of the current episode. CONCLUSION:Budesonide therapy to Crohn's disease patients appears to be more effective in patients with the more serious condition. Smoking may also affect the prognosis.


J Cell Biochem


Li Y,Meng X,Duan X,Tang T,He C,Li Y




Has Abstract


2019-06-01 00:00:00












  • The comparative study of the effects of Fe2 O3 and TiO2 micro- and nanoparticles on oxidative states of lung and bone marrow tissues and colony stimulating factor secretion.

    abstract::Nowadays, increased use of nanomaterials in industry and biomedicine poses potential risks to human health and the environment. Studying their possible toxicological effects is therefore of great significance. The present investigation was designed to examine the status of oxidative stress induced by nanoparticles (NP...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Soltani A,Kahkhaie KR,Haftcheshmeh SM,Jalali Nezhad AA,Akbar Boojar MM

    更新日期:2018-11-28 00:00:00

  • Extrachromosomal human immunodeficiency virus type-1 DNA can initiate a spreading infection of HL-60 cells.

    abstract::In this report, we describe a human immunodeficiency virus type-1 (HIV-1)-infected promyelocytic cell line, OM, derived from HL-60 cells. Although the OM cell line was biologically cloned twice, the pattern of HIV-1 expression during culture appeared analogous to a classical acute spreading infection and was inhibited...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Butera ST,Perez VL,Besansky NJ,Chan WC,Wu BY,Nabel GJ,Folks TM

    更新日期:1991-04-01 00:00:00

  • uPA and MMP-2 were involved in self-assembled network formation in a two dimensional co-culture model of bone marrow stromal cells and endothelial cells.

    abstract::Two dimensional (2D) co-cultures of human bone marrow stromal cells (HBMSCs) and human umbilical vein endothelial cells (HUVECs) stimulate osteoblastic differentiation of HBMSCs, induce the formation of self-assembled network and cell interactions between the two cell types involving many vascular molecules. Because o...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Li H,Daculsi R,Bareille R,Bourget C,Amedee J

    更新日期:2013-03-01 00:00:00

  • Comparative proteome analysis of 3T3-L1 adipocyte differentiation using iTRAQ-coupled 2D LC-MS/MS.

    abstract::Adipose tissue is critical in obesity and type II diabetes. Blocking of adipocyte differentiation is one of the anti-obesity strategies targeting on strong rise in fat storage and secretion of adipokine(s). However, the molecular basis of adipocyte differentiation and its regulation remains obscure. Therefore, we expo...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Ye F,Zhang H,Yang YX,Hu HD,Sze SK,Meng W,Qian J,Ren H,Yang BL,Luo MY,Wu X,Zhu W,Cai WJ,Tong JB

    更新日期:2011-10-01 00:00:00

  • Role of alpha v beta 5 and alpha v beta 6 integrin glycosylation in the adhesion of a colonic adenocarcinoma cell line (HT29-D4).

    abstract::We have previously characterized the expression of the alpha nu beta 5 and alpha nu beta 6 integrins as major receptors for the human colonic adenocarcinoma cell line (HT29-D4), on vitronectin and fibronectin, respectively [Lehmann et al. (1994): Cancer Res 54:2102-2107]. In the present work we investigated the glycos...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lehmann M,El Battari A,Abadie B,Martin JM,Marvaldi J

    更新日期:1996-05-01 00:00:00

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    abstract::Adiponectin is an important insulin-sensitizing adipokine with multiple beneficial effects on obesity-associated medical complications. It is secreted from adipocytes into circulation as high, medium, and low molecular weight forms (HMW, MMW, and LMW). Each oligomeric form of adiponectin exerts non-overlapping biologi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Chen Z,Zhang L,Yi J,Yang Z,Zhang Z,Li Z

    更新日期:2012-11-01 00:00:00

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    abstract::ERK1 and ERK2 share a great deal of homology and have been presumed to have similar functions. Available antibodies recognize both isoforms making the elucidation of functional differences challenging. Mitogen-activated protein (MAP) kinase networks are commonly depicted in the literature as linear and sequential phos...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Kang BS,Hwang YJ,Dong Z

    更新日期:2017-08-01 00:00:00

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    abstract::Death associated protein kinase 1 (DAPK1) was initially discovered in the progress of gamma-interferon induced programmed cell death, it is a key factor in the central nervous system, including Parkinson's disease (PD). However, the underlying mechanisms of DAPK1 in PD remain unclear and this research work aims to exp...

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    pub_type: 杂志文章


    authors: Lu Y,Gong Z,Jin X,Zhao P,Zhang Y,Wang Z

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    abstract::Focal adhesion kinase (FAK) is a structurally unique nonreceptor protein-tyrosine kinase that localizes to focal adhesion plaques. Regulation of its activity has been implicated in diverse signaling pathways, including those mediated by extracellular matrix/integrin interactions, G-protein coupled receptors for mitoge...

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    pub_type: 杂志文章


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    更新日期:2019-04-01 00:00:00

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    pub_type: 杂志文章


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  • Proteinase expression during differentiation of human osteoclasts in vitro.

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    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


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    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审


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    abstract::Hamster embryo cells metabolize benzo(a)pyrene to derivatives that covalently modify the nuclear macromolecules including proteins. Not all proteins are modified to the same extent nor by the same metabolites. In particular, a protein of apparent molecular weight 32,000 is highly modified by derivatives of trans-9,10-...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: MacLeod MC,Mansfield BK,Selkirk JK

    更新日期:1982-01-01 00:00:00

  • Epigenetic modifications, chromatin distribution and TP53 transcription in a model of breast cancer progression.

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    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Santos GC Jr,da Silva AP,Feldman L,Ventura GM,Vassetzky Y,de Moura Gallo CV

    更新日期:2015-04-01 00:00:00

  • miR-152/LIN28B axis modulates high-glucose-induced angiogenesis in human retinal endothelial cells via VEGF signaling.

    abstract::Diabetic retinopathy (DR) is a serious complication of diabetes contributing to blindness in patients. Inhibiting retinal neovascularization is a potent strategy for diabetic retinopathy treatment. Reportedly, the stable expression of lin-28 homolog B (LIN28B), a member of the highly conserved RNA-binding protein LIN2...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Fu X,Ou B

    更新日期:2020-02-01 00:00:00

  • Fluid flow induces Rankl expression in primary murine calvarial osteoblasts.

    abstract::Mechanical loading of bone generates fluid flow within the mineralized matrix that exerts fluid shear stress (FSS) on cells. We examined effects of FSS on receptor activator of nuclear factor kappa B ligand (RANKL), a critical factor for osteoclast formation. Primary murine osteoblasts were subjected to pulsatile FSS ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Mehrotra M,Saegusa M,Wadhwa S,Voznesensky O,Peterson D,Pilbeam C

    更新日期:2006-08-01 00:00:00

  • Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3β-dependent protein degradation.

    abstract::Endometrial carcinoma (EC) is one of the main gynecologic malignancies affecting women, but effective treatments are currently lacking. In the present study, we investigated the effect of sorafenib, a general kinase inhibitor, on several EC cell lines (HEC1A, HEC1B, and RL95-2). Sorafenib induced cell death in EC cell...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Sun NK,Huang SL,Chang TC,Chao CC

    更新日期:2013-08-01 00:00:00

  • Ecto-alkaline phosphatase activity identified at physiological pH range on intact P19 and HL-60 cells is induced by retinoic acid.

    abstract::The activity of membrane-bound alkaline phosphatase (ALP) expressed on the external surface of cultured murine P19 teratocarcinoma and human HL-60 myeloblastic leukemia cells was studied at physiological pH using p-nitrophenylphosphate (pNPP) as substrate. The rate of substrate hydrolysis catalyzed by intact viable ce...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Scheibe RJ,Kuehl H,Krautwald S,Meissner JD,Mueller WH

    更新日期:2000-01-01 00:00:00

  • Computational and mutational analysis of TatD DNase of Bacillus anthracis.

    abstract::The role of TatD DNases as DNA repair enzymes or cell death (apoptotic) nucleases is well established in prokaryotes as well as eukaryotes. The current study aims to characterize the TatD nuclease from Bacillus anthracis (Ba TatD) and to explore its key histidine catalytic residues. Ba TatD was found to be a metal-dep...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Singh D,Rahi A,Kumari R,Gupta V,Gautam G,Aggarwal S,Rehan M,Bhatnagar R

    更新日期:2019-02-05 00:00:00

  • HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins.

    abstract::Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses, and is often significantly overexpressed in solid tumors, but little is known of its role in human lung cancer. In this study, we demonstrated the aberrant expression of HDAC2 in lung cancer ti...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Jung KH,Noh JH,Kim JK,Eun JW,Bae HJ,Xie HJ,Chang YG,Kim MG,Park H,Lee JY,Nam SW

    更新日期:2012-06-01 00:00:00

  • Cyr61 is up-regulated in prostate cancer and associated with the p53 gene status.

    abstract::Cysteine-rich 61 (Cyr61) is a member of the CCN protein family that has been implicated in diverse biological processes such as cell adhesion, proliferation, angiogenesis, and tumorigenesis. Altered expression of Cyr61 is found to be associated with human cancers. Here we show that Cyr61 was up-regulated in prostate c...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Lv H,Fan E,Sun S,Ma X,Zhang X,Han DM,Cong YS

    更新日期:2009-03-01 00:00:00

  • Deletion of insulin receptor in the proximal tubule and fasting augment albumin excretion.

    abstract::The contribution of proximal tubules (PT) to albumin uptake is now well recognized, however, its regulation is understudied area. There are reports suggesting that insulin resistance is associated with the development of albuminuria in nondiabetic individuals. We have previously reported reduced insulin receptor (IR) ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章


    authors: Kumari M,Sharma R,Pandey G,Ecelbarger CM,Mishra P,Tiwari S

    更新日期:2019-06-01 00:00:00