The diagnosis and prognosis values of WNT mRNA expression in colon adenocarcinoma.

Abstract:

:WNT family genes have participated in the progression and development of many cancers, however, the association between colon adenocarcinoma (COAD) and WNTs have been rarely reported. This study investigated the significance of WNT genes expression in COAD from the standpoint of diagnosis and prognosis. The RNA-sequencing dataset of COAD was downloaded from The Cancer Genome Atlas and University of California, Santa Cruz Xena browser. The biology functions of WNT genes were investigated by biological analysis. Biological analysis of WNT family genes indicated that WNT genes were noticeably enriched in the complex process of WNT signaling pathway. The Pearson correlation analysis suggested WNT1 and WNT9B had a strong correlation. And receiver operating characteristic curves suggested that most of the genes could serve as a significant diagnostic makers in COAD (P < .05), especially WNT2 and WNT7B had high diagnostic values that the area under curve were 0.997 (95% confidence interval [0.994-1.000]) and 0.961 (95%CI [0.939-0.983]), respectively. And our multivariate survival analysis suggested the downregulated of WNT10B (P < .05) showed a favor prognosis in COAD overall survival. And the risk score model predicted that the upregulated expression of WNT10B might increase the risk of death. The very study we had conducted suggested that WNT genes had a certain connection with the diagnosis and prognosis of COAD. The messenger RNA expression of WNT2 and WNT7B might become potentially diagnostic biomarkers, and WNT10B might serve as an independent prognosis indicator for COAD.

journal_name

J Cell Biochem

authors

Ruan GT,Zhu LC,Gong YZ,Liao XW,Wang XK,Liao C,Wang S,Yan L,Xie HL,Zhou X,Li YZ,Gao F

doi

10.1002/jcb.29582

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

3145-3161

issue

5-6

eissn

0730-2312

issn

1097-4644

journal_volume

121

pub_type

杂志文章
  • Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.

    abstract::Fibroblasts play a major role in processes such as wound repair, scarring, and fibrosis. Differentiation into myofibroblasts, characterized by upregulation of smooth muscle alpha-actin (smalpha) in response to profibrotic agents such as TGFbeta is believed to be an important step in fibrosis. Therefore, elucidating me...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.21154

    authors: Sousa AM,Liu T,Guevara O,Stevens J,Fanburg BL,Gaestel M,Toksoz D,Kayyali US

    更新日期:2007-04-15 00:00:00

  • Production of sulfated proteoglycans by human breast cancer cell lines: binding to fibroblast growth factor-2.

    abstract::The cellular distribution and nature of proteoglycans synthesised by human breast cancer cells in culture were studied. Proteoglycans were labelled with [35S] sulfate, purified, and characterised after ion-exchange chromatography followed by gel-filtration chromatography and treatment with glycosaminoglycan degrading ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:

    authors: Delehedde M,Deudon E,Boilly B,Hondermarck H

    更新日期:1997-03-15 00:00:00

  • TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineage.

    abstract::Basic helix-loop-helix (bHLH) transcription factors have been shown to play an important role in controlling cell type determination and differentiation. TWIST, a member of the bHLH transcription factor family, is involved in the development of mesodermally derived tissue, including the skeleton. We examined the role ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4644(19991215)75:4<566::aid-jcb

    authors: Lee MS,Lowe GN,Strong DD,Wergedal JE,Glackin CA

    更新日期:1999-12-15 00:00:00

  • DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells.

    abstract::Receptor activator of NF-kappaB ligand (RANKL) is a critical osteoclastogenic factor that is expressed on bone marrow stromal/preosteoblast cells. Most bone resorption stimuli induce osteoclast formation by modulating RANKL expression in these cells. However, little is known about the mechanisms regulating RANKL gene ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.21561

    authors: Sundaram K,Mani SK,Kitatani K,Wu K,Pestell RG,Reddy SV

    更新日期:2008-04-15 00:00:00

  • Activation of the Nrf2-ARE Signaling Pathway Prevents Hyperphosphatemia-Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells.

    abstract::This study investigates the effect of nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) signaling pathway in vascular calcification (VC) via inducing Autophagy in renal vascular smooth muscle cells (VSMCs). VSMCs were assigned into six experimental groups: the normal control, high pho...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26137

    authors: Yao L,Wang J,Tian BY,Xu TH,Sheng ZT

    更新日期:2017-12-01 00:00:00

  • In vitro and in vivo studies of ICE inhibitors.

    abstract::Interleukin-1 beta-converting enzyme (ICE) is a cysteine protease responsible for proteolytic activation of the biologically inactive interleukin-1 beta precursor to the proinflammatory cytokine. ICE and homologous proteases also appear to mediate intracellular protein degradation during programmed cell death. Inhibit...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Livingston DJ

    更新日期:1997-01-01 00:00:00

  • Overexpressed circ_0029426 in glioblastoma forecasts unfavorable prognosis and promotes cell progression by sponging miR-197.

    abstract::Accumulating studies indicates that circular RNAs (circRNAs) play an imperative role in modulating cancer progression and metastasis. In the previous study, elevated circ_0029426 was first observed in glioblastoma (GBM) tissues compared with normal tissues by circRNA microarray. Our aim is to study the function and me...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28313

    authors: Zhang G,Sun W,Zhu L,Feng Y,Wu L,Li T

    更新日期:2019-06-01 00:00:00

  • P-Glycoprotein Inhibition Sensitizes Human Breast Cancer Cells to Proteasome Inhibitors.

    abstract::Although effective for the treatment of hematological malignancies, the FDA approved proteasome inhibitors bortezomib and carfilzomib have limited efficacy in solid tumors including triple negative breast cancer (TNBC). Chemotherapy is the only option for treating TNBC due to the absence of specific therapeutic target...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25783

    authors: Deshmukh RR,Kim S,Elghoul Y,Dou QP

    更新日期:2017-05-01 00:00:00

  • Sea urchin zygote chromatin exhibit an unfolded nucleosomal array during the first S phase.

    abstract::To investigate changes in chromatin organization associated with DNA replication during the first stages of development of the sea urchin Tetrapygus niger, we compared micrococcal nuclease (MNase) digestion patterns of chromatin from zygotes harvested during the first S phase and from unfertilized eggs. We observed th...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240590205

    authors: Imschenetzky M,Puchi M,Gutierrez S,Montecino M

    更新日期:1995-10-01 00:00:00

  • 4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.

    abstract::Elevated cellular oxidative stress and oxidative DNA damage are key contributors to impaired cardiac function in diabetes. During chronic inflammation, reactive oxygen species (ROS)-induced lipid peroxidation results in the formation of reactive aldehydes, foremost of which is 4-hydroxy-2-nonenal (4HNE). 4HNE forms co...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.29814

    authors: Pan G,Deshpande M,Pang H,Stemmer PM,Carruthers NJ,Shearn CT,Backos DS,Palaniyandi SS

    更新日期:2020-07-06 00:00:00

  • Transcriptional regulation of human eosinophil RNase2 by the liver-enriched hepatocyte nuclear factor 4.

    abstract::Human eosinophil-derived neurotoxin (EDN, RNase2) and eosinophil cationic protein (ECP, RNase3) sequences possess as high as 92% identity in their promoter regions. The major difference within this region is a 34-nucleotide (34-nt) segment appeared only in the edn promoter. In addition, six discrete segments existed i...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.22008

    authors: Wang HY,Ho PC,Lan CY,Chang MD

    更新日期:2009-02-01 00:00:00

  • Osajin Inhibits Solar UV-Induced Cyclooxygenase-2 Expression Through Direct Inhibition of RSK2.

    abstract::Solar ultraviolet light (sUV) has been shown to promote the development of skin disorders including inflammation, photoaging, and skin carcinogenesis. Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera, commonly referred to as the Osage orange. In this study, we observed that osajin inhi...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.26063

    authors: Kim JE,Heo YS,Lee KW

    更新日期:2017-11-01 00:00:00

  • Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments.

    abstract::Glioblastoma (GB) has a poor prognosis, despite current multimodality treatment. Beside surgical resection, adjuvant ionizing radiation (IR) combined with Temozolomide (TMZ) drug administration is the standard therapy for GB. This currently combined radio-chemotherapy treatment resulted in glial tumor cell death induc...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.24102

    authors: Palumbo S,Pirtoli L,Tini P,Cevenini G,Calderaro F,Toscano M,Miracco C,Comincini S

    更新日期:2012-07-01 00:00:00

  • Mouse embryonic fibroblast cells from transgenic mice overexpressing tNOX exhibit an altered growth and drug response phenotype.

    abstract::Mouse embryonic fibroblast (MEF) cells prepared from transgenic mice overexpressing a cancer-specific and growth-related cell surface NADH oxidase with protein disulfide-thiol interchange activity grew at rates approximately twice those of wild-type embryonic fibroblast cells. Growth of transgenic MEF cells overexpres...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.21184

    authors: Yagiz K,Wu LY,Kuntz CP,James Morré D,Morré DM

    更新日期:2007-05-15 00:00:00

  • Macrophages take up triacylglycerol-rich emulsions at a faster rate upon co-incubation with native and modified LDL: An investigation on the role of natural chylomicrons in atherosclerosis.

    abstract::Chylomicrons play a role in atherosclerosis, however, because the mechanisms involved in the cell uptake of these particles are not fully understood, investigations were carried out using a radioactively labeled protein-free triacylglycerol-rich emulsion incubated with peritoneal macrophages obtained from normal and a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10020

    authors: Carvalho MD,Harada LM,Gidlund M,Ketelhuth DF,Boschcov P,Quintão EC

    更新日期:2002-01-01 00:00:00

  • Regulation by EGF is maintained in an overexpressed chimeric EGFR/neu receptor tyrosine kinase.

    abstract::The effects of a ligand regulated neu tyrosine kinase were examined in NIH 3T3 cells. A chimeric construct encoding the human EGF receptor extracellular domain fused to the tyrosine kinase domain of the rat neu cDNA was expressed under the transcriptional control of the Moloney murine leukemia virus LTR promoter. This...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240420303

    authors: Lehväslaiho H,Sistonen L,diRenzo F,Partanen J,Comoglio P,Hölttä E,Alitalo K

    更新日期:1990-03-01 00:00:00

  • Na(+)-dependent, active nucleoside transport in S49 mouse lymphoma cells and loss in AE-1 mutant deficient in facilitated nucleoside transport.

    abstract::S49 murine lymphoma cells were examined for expression of various nucleoside transport systems using a non-metabolized nucleoside, formycin B, as substrate. Nitrobenzylthioinosine (NBTI)-sensitive, facilitated transport was the primary nucleoside transport system of the cells. The cells also expressed very low levels ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240460109

    authors: Plagemann PG

    更新日期:1991-05-01 00:00:00

  • Enhanced development of mouse single blastomeres into blastocysts via the simultaneous inhibition of TGF-β and ERK pathways in microdroplet culture.

    abstract::Optimization of an in vitro culture that supports blastocyst (BL) development from single blastomeres (SBs) is essential to generate additional embryos for farm animals and humans and unravel the mechanisms that underlie totipotency. In this study, we have examined BL development from SBs that were derived from 2-cell...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.27106

    authors: Yekani F,Azarnia M,Esfandiari F,Hassani SN,Baharvand H

    更新日期:2018-09-01 00:00:00

  • Neural crest-derived stem cells display a wide variety of characteristics.

    abstract::A recent burst of findings has shown that neural crest-derived stem cells (NCSCs) can be found in diverse mammalian tissues. In addition to their identification in tissues that are known to be derived from the neural crest, recent studies have revealed NCSCs in tissues that are not specifically derived from the neural...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章,评审

    doi:10.1002/jcb.22213

    authors: Nagoshi N,Shibata S,Nakamura M,Matsuzaki Y,Toyama Y,Okano H

    更新日期:2009-08-15 00:00:00

  • LncRNA MALAT-1 Elevates HMGB1 to Promote Autophagy Resulting in Inhibition of Tumor Cell Apoptosis in Multiple Myeloma.

    abstract::Long non-coding RNAs (lncRNAs) can participate in the pathological process of multiple myeloma (MM) via regulation of specific gene expression and function. This research aimed to study the role of MALAT-1 and the underlying mechanism in MM. In this study, the expression of MALAT-1 and HMGB1 protein in the bone marrow...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.25987

    authors: Gao D,Lv AE,Li HP,Han DH,Zhang YP

    更新日期:2017-10-01 00:00:00

  • Effect of growth and maturation on membrane-initiated actions of 1,25-dihydroxyvitamin D3-II: calcium transport, receptor kinetics, and signal transduction in intestine of female chickens.

    abstract::We recently reported (Larsson and Nemere [2003]: Endocrinology 144:1726) the effects of growth and maturation on 1,25(OH)2D3-membrane initiated effects in the intestine of male chickens. Here we extend our observations to studies on females with two stages of high calcium demand: growth (7-14 weeks) and egg laying (28...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.10696

    authors: Larsson B,Nemere I

    更新日期:2003-12-01 00:00:00

  • Isolation and characterization of the chicken vitamin D receptor gene and its promoter.

    abstract::The sequences from several independent cDNA clones encoding the chicken vitamin D receptor as well as primer extension assay have clearly delineated the 5' terminus and the transcriptional start site. Screening a chicken genomic library produced genomic clones containing vitamin D receptor (VDR) gene fragments. Restri...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:

    authors: Lu Z,Jehan F,Zierold C,DeLuca HF

    更新日期:2000-02-01 00:00:00

  • Introduction of an initiator element in the mouse thymidylate synthase promoter alters S phase regulation but has no effect on promoter bidirectionality.

    abstract::The promoter of the mouse thymidylate synthase (TS) gene lacks a TATAA box and an initiator element, is bidirectional and initiates transcription at multiple start sites across broad initiation windows upstream and downstream of the 30 nt essential promoter region. The TS promoter also plays an essential role in the p...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.20666

    authors: Kapadia F,Johnson LF

    更新日期:2006-02-15 00:00:00

  • Curcumin prevents lipopolysaccharide-induced atrogin-1/MAFbx upregulation and muscle mass loss.

    abstract::Because elevated ubiquitin ligase atrogin-1/MAFbx and MuRF1 mediate skeletal muscle wasting associated with various catabolic conditions, the signaling pathways involved in the upregulation of these genes under pathological conditions are considered therapeutic targets. AKT and NF-kappaB have been previously shown to ...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.21060

    authors: Jin B,Li YP

    更新日期:2007-03-01 00:00:00

  • Cellular responses elicited by insulin mimickers in cells lacking detectable plasma membrane insulin receptors.

    abstract::Madin-Darby canine kidney (MDCK) cells were previously shown to have few or no plasma membrane insulin binding sites (Hofmann et al: J Biol Chem 258:11774, 1983]. Accordingly, neither insulin-stimulated incorporation of [14C]glucose into glycogen, nor insulin-induced uptake of radiolabeled alpha-aminoisobutyrate ([3H]...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240270409

    authors: Hofmann C,Crettaz M,Bruns P,Hessel P,Hadawi G

    更新日期:1985-01-01 00:00:00

  • Sequence analysis and in vitro transcription of portions of the Epstein-Barr virus genome.

    abstract::The 17,180 base-pair Eco-RI-C fragment of Epstein-Barr virus has been sequenced in its entirety. This same fragment has also been analyzed for RNA polymerase II promoters, which are active in a soluble in vitro assay. These data are compared to the availability of predicted open reading frames and potential nucleotide...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.240190308

    authors: Deininger PL,Bankier A,Farrell P,Baer R,Barrell B

    更新日期:1982-01-01 00:00:00

  • Protein tyrosine phosphatase SHP-1 specifically recognizes C-terminal residues of its substrates via helix alpha0.

    abstract::The catalytic domain of protein tyrosine phosphatase SHP-1 possesses distinct substrate specificity. It recognizes the P-3 to P-5 residues of its substrates via the beta5-loop-beta6 region. To study the substrate specificity further, we determined the structure of the catalytic domain of SHP-1 (C455S) complexed with a...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.1195

    authors: Yang J,Cheng Z,Niu T,Liang X,Zhao ZJ,Zhou GW

    更新日期:2001-06-26 00:00:00

  • Downregulated NOX4 underlies a novel inhibitory role of microRNA-137 in prostate cancer.

    abstract::Prostate cancer is the second highest caused by cancer-related death among males. microRNAs (miRs) have been reported to participate in carcinogenesis, yet their roles in prostate cancer are rarely studied or investigated. Therefore, the present study attempted to explore the effect of miR-137 in prostate cancer via r...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28306

    authors: Wu QQ,Zheng B,Weng GB,Yang HM,Ren Y,Weng XJ,Zhang SW,Zhu WZ

    更新日期:2019-06-01 00:00:00

  • Oxymatrine ameliorates diabetes-induced aortic endothelial dysfunction via the regulation of eNOS and NOX4.

    abstract:AIM:Oxymatrine (OMT) is the major quinolizidine alkaloid extracted from the root of Sophora flavescens Ait (the Chinese herb Kushen) and exhibits diverse pharmacological actions. In this study, we investigated the effects of OMT on diabetes-associated aortic endothelial dysfunction in a rat model of diabetes and its mec...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:10.1002/jcb.28006

    authors: Wang L,Li X,Zhang Y,Huang Y,Zhang Y,Ma Q

    更新日期:2018-11-19 00:00:00

  • Role of hypoxia and extracellular matrix-integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cells.

    abstract::The retinal pigmented epithelium (RPE) is a monolayer of polarized cells located between retinal photoreceptors and blood vessels of the choroid. The basal surface of RPE cells rests on Bruch's membrane, a complex extracellular matrix structure which becomes abnormal in several disease processes, including age-related...

    journal_title:Journal of cellular biochemistry

    pub_type: 杂志文章

    doi:

    authors: Mousa SA,Lorelli W,Campochiaro PA

    更新日期:1999-07-01 00:00:00