Abstract:
:The aim was to develop novel fibres by enzymatic synthesis, to determine their total dietary fibre by AOAC method 2009.01 and to estimate their potential digestibility and assess their digestibility in vivo using glycaemic and insulinaemic responses as markers in mice and randomised clinical trial models. We found that fibre candidates to which α-(1,2) branching was added were resistant to digestion in the mouse model, depending on the amount of branching. These results show that in vivo models are needed to reliably assess the digestibility of α-glycosidic-linked oligomeric dietary fibre candidates, possibly due to absence of brush border α-glucosidase activity in the current in vitro assessment. α-(1,3)-linked and α-(1,6)-linked glucose oligomers were completely digested in humans and mice. In conclusion, it is possible to develop dietary soluble fibres by enzymatic synthesis. Adding α-(1,2) branching increases their resistance to digestion in vivo and can thus improve their suitability as potential fibre candidates. Clinical Trial Registry: ClinicalTrials.gov, NCT02701270.
journal_name
Int J Food Sci Nutrjournal_title
International journal of food sciences and nutritionauthors
Hasselwander O,DiCosimo R,You Z,Cheng Q,Rothman SC,Suwannakham S,Baer ZC,Roesch BM,Ruebling-Jass KD,Lai JP,Hurteau RE,Marquez ML,Kopatsis AD,Ouwehand AC,Forssten SD,Mukerji P,Caverly Rae JM,Dragan YP,Damewood JR,Tiidoi
10.1080/09637486.2017.1295027subject
Has Abstractpub_date
2017-11-01 00:00:00pages
849-864issue
7eissn
0963-7486issn
1465-3478journal_volume
68pub_type
杂志文章abstract::Caffeic acid phenethyl ester (CAPE), a plant polyphenolic concentrated in honeybee propolis, has been found to be biologically active in a variety of pathways. The aim of this study was to determine the antioxidant activity of CAPE using different methods such as total antioxidant activity by the thiocyanate method, 2...
journal_title:International journal of food sciences and nutrition
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journal_title:International journal of food sciences and nutrition
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journal_title:International journal of food sciences and nutrition
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pub_type: 杂志文章,随机对照试验
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