Abstract：
:Resveratrol (RSV) can protect against non-communicable diseases by improving cholesterol metabolism. However, it is unclear that effects of maternal RSV intake on health of adult offspring. In this study, we examined effects of maternal RSV intake during lactation on cholesterol metabolism in adult male rat offspring. Female Wistar rats were fed a control diet (CON) supplemented with or without RSV (20 mg/kg body weight/day) during their lactation period. Male offspring were weaned onto a standard diet and maintained on this diet for 36 weeks. As a result, plasma cholesterol level significantly decreased in RSV offspring compared to CON offspring. Furthermore, a decrease in hepatic 3-hydroxy-3-methylglutaryl-CoA reductase level and an increase in hepatic LDL-receptor level were observed in the RSV offspring. These results indicate that maternal RSV intake causes long-term decrease in plasma cholesterol level in the offspring through suppression of hepatic cholesterol biosynthesis and promotion of hepatic cholesterol uptake.
journal_name
Int J Food Sci Nutrjournal_title
International journal of food sciences and nutritionauthors
Yamasaki S,Tomihara T,Kimura G,Ueno Y,Ketema RM,Sato S,Mukai Y,Sikder T,Kurasaki M,Hosokawa T,Saito Tdoi
10.1080/09637486.2019.1639638subject
Has Abstractpub_date
2020-03-01 00:00:00pages
226-234issue
2eissn
0963-7486issn
1465-3478journal_volume
71pub_type
杂志文章abstract：:Reports have shown that Delta-5 polyunsaturated fatty acids (-5 PUFA) are enriched at sn-1,3 positions of triacylglycerols (TAG) in pine (Pinus koraiensis) nut oil (Pn). As a major Delta-5 PUFA, pinolenic acid (Pi) is about 14.2% in the oil, while the percentage of Pi at the sn-1 and/or sn-3 positions in TAG was found...
journal_title：International journal of food sciences and nutrition
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journal_title：International journal of food sciences and nutrition
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