Degree of lipid saturation affects depressive-like behaviour and gut microbiota in mice.

Abstract:

:This study explored the effects of the degree of lipid saturation on depressive behaviour and gut microbiota in mice. Thirty-two mice were divided into normal (N), Prozac (NP), lard (L) and fish oil (F) groups. After a 12-week dietary intervention, the open field test (OFT) and the forced swim test (FST) were conducted before sacrifice. The mice in the L group exhibited anxiety-like behaviours in the OFT and depressive-like behaviours in the FST. A significant difference was observed in β-diversity indices between the L group and the F group. The abundance of Allobaculum and Bifidobacterium was significantly higher in the F group than in the L and N groups. The prefrontal cortex fatty acid composition was altered in various lipid-treated groups and was highly correlated with depressive-like behaviours. In conclusion, the degree of lipid saturation affects depressive-like behaviour, gut microbiota composition, and the prefrontal cortex fatty acid profile in mice.

journal_name

Int J Food Sci Nutr

authors

Lee HC,Lo YC,Yu SC,Tung TH,Lin IH,Huang SY

doi

10.1080/09637486.2019.1681380

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

440-452

issue

4

eissn

0963-7486

issn

1465-3478

journal_volume

71

pub_type

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